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Article: Liver transplantation: would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?

TitleLiver transplantation: would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?
Authors
KeywordsLiver transplantation (LT)
Liver resection (LR)
Portal vein
Tumour thrombus
Issue Date2021
PublisherAME Publishing Company. The Journal's web site is located at https://hbsn.amegroups.com/
Citation
Hepatobiliary Surgery and Nutrition, 2021, v. 10 n. 3, p. 308-314 How to Cite?
AbstractBackground: Hepatocellular carcinoma (HCC) with portal vein tumour thrombus (PVTT) signifies advanced disease, whether LT confers any survival superiority over resection remains uncertain. Methods: A propensity score matched (PSM) analysis of liver transplantation (LT) and liver resection (LR) for HCC with PVTT was performed. Results: A consecutive series of 88 patients who received either LT (10 DDLTs and 3 LDLTs) or LR (n=75) respectively were recruited. Before PSM, the LT group has a higher MELD score (17.3 vs. 7.8, P<0.001), lower serum AFP levels (96 vs. 2,164 ng/mL, P=0.017) and smaller tumour size (4 vs. 10 cm, P<0.001). The 5-year overall survival for LT and LR were 55.4% and 15.9% respectively (P=0.007). After matching for serum AFP levels and tumour size, 1-, 3- and 5-year overall survival for LT were 81 ng/mL, 3.9 cm, 80%, 70% and 70% and the corresponding rates for LR were 1,417 ng/mL, 5.3 cm, 51.8%, 19,6% and 9.8% (P value =0.12, 0.27 and 0.009 respectively). Conclusions: LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level. A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/304708
ISSN
2023 Impact Factor: 6.1

 

DC FieldValueLanguage
dc.contributor.authorMa, KW-
dc.contributor.authorChan, ACY-
dc.contributor.authorChok, KSH-
dc.contributor.authorShe, WH-
dc.contributor.authorCheung, TT-
dc.contributor.authorDai, WC-
dc.contributor.authorFung, JYY-
dc.contributor.authorLo, CM-
dc.date.accessioned2021-10-05T02:34:01Z-
dc.date.available2021-10-05T02:34:01Z-
dc.date.issued2021-
dc.identifier.citationHepatobiliary Surgery and Nutrition, 2021, v. 10 n. 3, p. 308-314-
dc.identifier.issn2304-3881-
dc.identifier.urihttp://hdl.handle.net/10722/304708-
dc.descriptionOpen Access Journal-
dc.description.abstractBackground: Hepatocellular carcinoma (HCC) with portal vein tumour thrombus (PVTT) signifies advanced disease, whether LT confers any survival superiority over resection remains uncertain. Methods: A propensity score matched (PSM) analysis of liver transplantation (LT) and liver resection (LR) for HCC with PVTT was performed. Results: A consecutive series of 88 patients who received either LT (10 DDLTs and 3 LDLTs) or LR (n=75) respectively were recruited. Before PSM, the LT group has a higher MELD score (17.3 vs. 7.8, P<0.001), lower serum AFP levels (96 vs. 2,164 ng/mL, P=0.017) and smaller tumour size (4 vs. 10 cm, P<0.001). The 5-year overall survival for LT and LR were 55.4% and 15.9% respectively (P=0.007). After matching for serum AFP levels and tumour size, 1-, 3- and 5-year overall survival for LT were 81 ng/mL, 3.9 cm, 80%, 70% and 70% and the corresponding rates for LR were 1,417 ng/mL, 5.3 cm, 51.8%, 19,6% and 9.8% (P value =0.12, 0.27 and 0.009 respectively). Conclusions: LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level. A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered.-
dc.languageeng-
dc.publisherAME Publishing Company. The Journal's web site is located at https://hbsn.amegroups.com/-
dc.relation.ispartofHepatobiliary Surgery and Nutrition-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectLiver transplantation (LT)-
dc.subjectLiver resection (LR)-
dc.subjectPortal vein-
dc.subjectTumour thrombus-
dc.titleLiver transplantation: would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?-
dc.typeArticle-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailFung, JYY: jfung@hkucc.hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityMa, KW=rp02758-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros326536-
dc.identifier.volume10-
dc.identifier.issue3-
dc.identifier.spage308-
dc.identifier.epage314-
dc.publisher.placeChina-

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