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Article: Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction

TitleNeurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction
Authors
Chung, TWHZhang, HWong, FKCSridhar, SChan, KHCheng, VCCYuen, KYHung, IFNMak, HKF
KeywordsCOVID-19
olfactory dysfunction
vitamin A
smell training
resting-state fMRI
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/brainsci
Citation
Brain Sciences, 2021, v. 11 n. 6, p. article no. 686 How to Cite?
DOI: http://dx.doi.org/10.3390/brainsci11060686
AbstractNon-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120%), left: 37.5 mm3 to 42 mm3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].
Persistent Identifierhttp://hdl.handle.net/10722/304484
ISSN
2076-3425
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.796
PubMed Central ID
PMC8224593
ISI Accession Number ID
WOS:000665321600001

 

DC FieldValueLanguage
dc.contributor.authorChung, TWH-
dc.contributor.authorZhang, H-
dc.contributor.authorWong, FKC-
dc.contributor.authorSridhar, S-
dc.contributor.authorChan, KH-
dc.contributor.authorCheng, VCC-
dc.contributor.authorYuen, KY-
dc.contributor.authorHung, IFN-
dc.contributor.authorMak, HKF-
dc.date.accessioned2021-09-23T09:00:41Z-
dc.date.available2021-09-23T09:00:41Z-
dc.date.issued2021-
dc.identifier.citationBrain Sciences, 2021, v. 11 n. 6, p. article no. 686-
dc.identifier.issn2076-3425-
dc.identifier.urihttp://hdl.handle.net/10722/304484-
dc.description.abstractNon-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120%), left: 37.5 mm3 to 42 mm3 (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/brainsci-
dc.relation.ispartofBrain Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectolfactory dysfunction-
dc.subjectvitamin A-
dc.subjectsmell training-
dc.subjectresting-state fMRI-
dc.titleNeurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction-
dc.typeArticle-
dc.identifier.emailChung, TWH: tomwhc@hku.hk-
dc.identifier.emailZhang, H: shirlzh7@hku.hk-
dc.identifier.emailSridhar, S: sid8998@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailMak, HKF: makkf@hku.hk-
dc.identifier.authoritySridhar, S=rp02249-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityMak, HKF=rp00533-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/brainsci11060686-
dc.identifier.pmid34071007-
dc.identifier.pmcidPMC8224593-
dc.identifier.scopuseid_2-s2.0-85108002176-
dc.identifier.hkuros325382-
dc.identifier.volume11-
dc.identifier.issue6-
dc.identifier.spagearticle no. 686-
dc.identifier.epagearticle no. 686-
dc.identifier.isiWOS:000665321600001-
dc.publisher.placeSwitzerland-

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