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Article: Clinical Application of AMH Measurement in Assisted Reproduction
Title | Clinical Application of AMH Measurement in Assisted Reproduction |
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Authors | |
Keywords | anti-Müllerian hormone assisted reproduction in vitro fertilization intrauterine insemination ovarian response |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/endocrinology/ |
Citation | Frontiers in Endocrinology, 2020, v. 11, p. article no. 606744 How to Cite? |
Abstract | Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ability to predict live birth and should not be used to refuse treatment, but rather to inform counselling and shared decision making. The use of absolute clinical thresholds to stratify patient phenotypes, assess discordance and individualize treatment protocols in non-validated algorithms combined with the lack of standardization of assays may result in inappropriate classification and sub-optimal clinical decision making. We propose that holistic baseline phenotyping, incorporating antral follicle count and other patient characteristics is critical. Treatment decisions driven by validated algorithms that use ovarian reserve biomarkers as continuous measures, reducing the risk of misclassification, are likely to improve overall outcomes for our patients. |
Persistent Identifier | http://hdl.handle.net/10722/304331 |
ISSN | 2023 Impact Factor: 3.9 2023 SCImago Journal Rankings: 1.240 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, HW | - |
dc.contributor.author | Nelson, SM | - |
dc.date.accessioned | 2021-09-23T08:58:33Z | - |
dc.date.available | 2021-09-23T08:58:33Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Endocrinology, 2020, v. 11, p. article no. 606744 | - |
dc.identifier.issn | 1664-2392 | - |
dc.identifier.uri | http://hdl.handle.net/10722/304331 | - |
dc.description.abstract | Anti-Müllerian hormone reflects the continuum of the functional ovarian reserve, and as such can predict ovarian response to gonadotropin stimulation and be used to individualize treatment pathways to improve efficacy and safety. However, consistent with other biomarkers and age-based prediction models it has limited ability to predict live birth and should not be used to refuse treatment, but rather to inform counselling and shared decision making. The use of absolute clinical thresholds to stratify patient phenotypes, assess discordance and individualize treatment protocols in non-validated algorithms combined with the lack of standardization of assays may result in inappropriate classification and sub-optimal clinical decision making. We propose that holistic baseline phenotyping, incorporating antral follicle count and other patient characteristics is critical. Treatment decisions driven by validated algorithms that use ovarian reserve biomarkers as continuous measures, reducing the risk of misclassification, are likely to improve overall outcomes for our patients. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/endocrinology/ | - |
dc.relation.ispartof | Frontiers in Endocrinology | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | anti-Müllerian hormone | - |
dc.subject | assisted reproduction | - |
dc.subject | in vitro fertilization | - |
dc.subject | intrauterine insemination | - |
dc.subject | ovarian response | - |
dc.title | Clinical Application of AMH Measurement in Assisted Reproduction | - |
dc.type | Article | - |
dc.identifier.email | Li, HW: raymondli@hku.hk | - |
dc.identifier.authority | Li, HW=rp01649 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fendo.2020.606744 | - |
dc.identifier.scopus | eid_2-s2.0-85098084381 | - |
dc.identifier.hkuros | 325165 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 606744 | - |
dc.identifier.epage | article no. 606744 | - |
dc.identifier.isi | WOS:000601254600001 | - |
dc.publisher.place | Switzerland | - |