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Article: TLR5 Supports Development of Placental Labyrinthine Zone in Mice

TitleTLR5 Supports Development of Placental Labyrinthine Zone in Mice
Authors
KeywordsCREB
labyrinthine zone
mTOR
placenta
TLR5
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/cell-and-developmental-biology
Citation
Frontiers in Cell and Developmental Biology, 2021, v. 9, p. article no. 711253 How to Cite?
AbstractToll plays an important role in innate immunity and embryonic development in lower-ranked animals, but in mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal development of immunity only. Here, we discovered a role of TLR5 in placental development. Tlr5 was highly transcribed during the placenta-forming and functional phases. TLR5 deletion led to a smaller placental labyrinthine zone and lower embryo weight, and the smaller size of embryo was overcorrected, resulting in a higher postnatal body weight. Examination of TLR5-deficient conceptus revealed a decrease in nuclear cAMP-response element-binding protein (CREB), mechanistic target of rapamycin (mTOR) and insulin growth factor-1 receptor (IGF1R) abundances in the placenta-forming phase. Non-flagellin-based TLR5 ligands were detected in serum of female mice and the overexpression of TLR5 alone was sufficient to induce CREB nuclear translocation and mTOR transcriptional activation in trophoblasts. Taken together, we uncovered the participation of TLR5 in the early placental formation in mice, unveiling a role of TLR in embryonic development in higher-ranked animals.
Persistent Identifierhttp://hdl.handle.net/10722/304260
ISSN
2020 Impact Factor: 6.684
2020 SCImago Journal Rankings: 2.452
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYiu, JHC-
dc.contributor.authorCHEUNG, SWM-
dc.contributor.authorCAI, J-
dc.contributor.authorChan, KS-
dc.contributor.authorCHEN, J-
dc.contributor.authorCheong, LY-
dc.contributor.authorCHAU, HT-
dc.contributor.authorXu, A-
dc.contributor.authorLi, RHW-
dc.contributor.authorWoo, CW-
dc.date.accessioned2021-09-23T08:57:30Z-
dc.date.available2021-09-23T08:57:30Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Cell and Developmental Biology, 2021, v. 9, p. article no. 711253-
dc.identifier.issn2296-634X-
dc.identifier.urihttp://hdl.handle.net/10722/304260-
dc.description.abstractToll plays an important role in innate immunity and embryonic development in lower-ranked animals, but in mammals, the homolog toll-like receptors (TLR) are reported to facilitate postnatal development of immunity only. Here, we discovered a role of TLR5 in placental development. Tlr5 was highly transcribed during the placenta-forming and functional phases. TLR5 deletion led to a smaller placental labyrinthine zone and lower embryo weight, and the smaller size of embryo was overcorrected, resulting in a higher postnatal body weight. Examination of TLR5-deficient conceptus revealed a decrease in nuclear cAMP-response element-binding protein (CREB), mechanistic target of rapamycin (mTOR) and insulin growth factor-1 receptor (IGF1R) abundances in the placenta-forming phase. Non-flagellin-based TLR5 ligands were detected in serum of female mice and the overexpression of TLR5 alone was sufficient to induce CREB nuclear translocation and mTOR transcriptional activation in trophoblasts. Taken together, we uncovered the participation of TLR5 in the early placental formation in mice, unveiling a role of TLR in embryonic development in higher-ranked animals.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/cell-and-developmental-biology-
dc.relation.ispartofFrontiers in Cell and Developmental Biology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCREB-
dc.subjectlabyrinthine zone-
dc.subjectmTOR-
dc.subjectplacenta-
dc.subjectTLR5-
dc.titleTLR5 Supports Development of Placental Labyrinthine Zone in Mice-
dc.typeArticle-
dc.identifier.emailYiu, JHC: jenseny@hku.hk-
dc.identifier.emailCheong, LY: u3003285@connect.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailWoo, CW: cwhwoo@hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityWoo, CW=rp01860-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fcell.2021.711253-
dc.identifier.pmid34395439-
dc.identifier.pmcidPMC8356041-
dc.identifier.scopuseid_2-s2.0-85112282918-
dc.identifier.hkuros325210-
dc.identifier.volume9-
dc.identifier.spagearticle no. 711253-
dc.identifier.epagearticle no. 711253-
dc.identifier.isiWOS:000683868500001-
dc.publisher.placeSwitzerland-

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