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Article: Use of oral progestogen in women with threatened miscarriage in the first trimester: a randomized double-blind controlled trial

TitleUse of oral progestogen in women with threatened miscarriage in the first trimester: a randomized double-blind controlled trial
Authors
Keywordsmiscarriage
first trimester
vaginal bleeding
oral progestogen
threatened miscarriage
Issue Date2021
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2021, v. 36 n. 3, p. 587-595 How to Cite?
AbstractSTUDY QUESTION Will use of oral progestogen in women with threatened miscarriage in the first trimester reduce the miscarriage rate when compared with placebo? SUMMARY ANSWER Use of oral progestogen in women with threatened miscarriage in the first trimester did not reduce miscarriage before 20 weeks when compared with placebo. WHAT IS KNOWN ALREADY Miscarriage is a common complication of pregnancy and occurs in 15–20% of clinically recognized pregnancies. Use of vaginal progestogens is not effective in reducing miscarriage but there is still no good evidence to support use of oral progestogen for the treatment of threatened miscarriage. STUDY DESIGN, SIZE, DURATION This was a randomized double-blind controlled trial. A total of 406 women presenting with threatened miscarriage in the first trimester were recruited from 30 March 2016 to May 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS Women attending Early Pregnancy Assessment Clinics because of vaginal bleeding during the first trimester were recruited and randomly assigned to use dydrogesterone 40 mg orally, followed by 10 mg orally three times a day or placebo until 12 completed weeks of gestation or 1 week after the bleeding stopped, whichever was later. The primary outcome was the miscarriage rate before 20 weeks of gestation. MAIN RESULTS AND THE ROLE OF CHANCE The two groups of women had comparable age, BMI, number of previous miscarriages, gestation and ultrasound findings at presentation. The miscarriage rate before 20 weeks of gestation was similar in both groups, being 12.8% (26/203) in the progestogen group and 14.3% (29/203) in the placebo group (relative risk 0.897, 95% CI 0.548–1.467; P = 0.772). The live birth rate was 81.3% in the progestogen group versus 83.3% in the placebo group (P = 0.697). No significant differences were found between the two groups in terms of obstetric outcomes and side effects. LIMITATIONS, REASONS FOR CAUTION The primary outcome was the miscarriage rate, rather than the live birth rate. Women were recruited from Early Pregnancy Assessment Clinics and those with heavy vaginal bleeding might be admitted into wards directly instead of attending Early Pregnancy Assessment Clinic. The severity of vaginal bleeding was subjectively graded by women themselves. The sample size was not adequate to demonstrate a smaller difference in the miscarriage rate between the progestogen and placebo groups. We did not exclude women with multiple pregnancy, which increased the risk of miscarriage although there was only one set of twin pregnancy in the placebo group. WIDER IMPLICATIONS OF THE FINDINGS Use of oral progestogen is not recommended in women with threatened miscarriage in the first trimester. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the Health and Medical Research Fund, HKSAR (reference number 12132341). All authors declared no conflict of interest. TRIAL REGISTRATION NUMBER ClinicalTrials.gov with an identifier NCT02128685. TRIAL REGISTRATION DATE 1 May 2014. DATE OF FIRST PATIENT'S ENROLMENT 30 March 2016.
Persistent Identifierhttp://hdl.handle.net/10722/304046
ISSN
2021 Impact Factor: 6.353
2020 SCImago Journal Rankings: 2.446
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, DMK-
dc.contributor.authorCheung, KW-
dc.contributor.authorKo, JKY-
dc.contributor.authorYung, SSF-
dc.contributor.authorLai, SF-
dc.contributor.authorLam, MT-
dc.contributor.authorNg, DYT-
dc.contributor.authorLee, VCY-
dc.contributor.authorLi, RHW-
dc.contributor.authorNg, EHY-
dc.date.accessioned2021-09-23T08:54:29Z-
dc.date.available2021-09-23T08:54:29Z-
dc.date.issued2021-
dc.identifier.citationHuman Reproduction, 2021, v. 36 n. 3, p. 587-595-
dc.identifier.issn0268-1161-
dc.identifier.urihttp://hdl.handle.net/10722/304046-
dc.description.abstractSTUDY QUESTION Will use of oral progestogen in women with threatened miscarriage in the first trimester reduce the miscarriage rate when compared with placebo? SUMMARY ANSWER Use of oral progestogen in women with threatened miscarriage in the first trimester did not reduce miscarriage before 20 weeks when compared with placebo. WHAT IS KNOWN ALREADY Miscarriage is a common complication of pregnancy and occurs in 15–20% of clinically recognized pregnancies. Use of vaginal progestogens is not effective in reducing miscarriage but there is still no good evidence to support use of oral progestogen for the treatment of threatened miscarriage. STUDY DESIGN, SIZE, DURATION This was a randomized double-blind controlled trial. A total of 406 women presenting with threatened miscarriage in the first trimester were recruited from 30 March 2016 to May 2018. PARTICIPANTS/MATERIALS, SETTING, METHODS Women attending Early Pregnancy Assessment Clinics because of vaginal bleeding during the first trimester were recruited and randomly assigned to use dydrogesterone 40 mg orally, followed by 10 mg orally three times a day or placebo until 12 completed weeks of gestation or 1 week after the bleeding stopped, whichever was later. The primary outcome was the miscarriage rate before 20 weeks of gestation. MAIN RESULTS AND THE ROLE OF CHANCE The two groups of women had comparable age, BMI, number of previous miscarriages, gestation and ultrasound findings at presentation. The miscarriage rate before 20 weeks of gestation was similar in both groups, being 12.8% (26/203) in the progestogen group and 14.3% (29/203) in the placebo group (relative risk 0.897, 95% CI 0.548–1.467; P = 0.772). The live birth rate was 81.3% in the progestogen group versus 83.3% in the placebo group (P = 0.697). No significant differences were found between the two groups in terms of obstetric outcomes and side effects. LIMITATIONS, REASONS FOR CAUTION The primary outcome was the miscarriage rate, rather than the live birth rate. Women were recruited from Early Pregnancy Assessment Clinics and those with heavy vaginal bleeding might be admitted into wards directly instead of attending Early Pregnancy Assessment Clinic. The severity of vaginal bleeding was subjectively graded by women themselves. The sample size was not adequate to demonstrate a smaller difference in the miscarriage rate between the progestogen and placebo groups. We did not exclude women with multiple pregnancy, which increased the risk of miscarriage although there was only one set of twin pregnancy in the placebo group. WIDER IMPLICATIONS OF THE FINDINGS Use of oral progestogen is not recommended in women with threatened miscarriage in the first trimester. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the Health and Medical Research Fund, HKSAR (reference number 12132341). All authors declared no conflict of interest. TRIAL REGISTRATION NUMBER ClinicalTrials.gov with an identifier NCT02128685. TRIAL REGISTRATION DATE 1 May 2014. DATE OF FIRST PATIENT'S ENROLMENT 30 March 2016.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/-
dc.relation.ispartofHuman Reproduction-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Reproduction following peer review. The definitive publisher-authenticated version Human Reproduction, 2021, v. 36 n. 3, p. 587-595 is available online at: https://academic.oup.com/humrep/article-abstract/36/3/587/6040661?redirectedFrom=fulltext-
dc.subjectmiscarriage-
dc.subjectfirst trimester-
dc.subjectvaginal bleeding-
dc.subjectoral progestogen-
dc.subjectthreatened miscarriage-
dc.titleUse of oral progestogen in women with threatened miscarriage in the first trimester: a randomized double-blind controlled trial-
dc.typeArticle-
dc.identifier.emailCheung, KW: kawang@hku.hk-
dc.identifier.emailYung, SSF: ssfyung@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityYung, SSF=rp00287-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturepostprint-
dc.identifier.doi10.1093/humrep/deaa327-
dc.identifier.pmid33331637-
dc.identifier.scopuseid_2-s2.0-85102212901-
dc.identifier.hkuros325097-
dc.identifier.volume36-
dc.identifier.issue3-
dc.identifier.spage587-
dc.identifier.epage595-
dc.identifier.isiWOS:000651812800009-
dc.publisher.placeUnited Kingdom-

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