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- Publisher Website: 10.1002/jbio.202000392
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- PMID: 33205905
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Article: Near‐infrared double‐illumination optical‐resolution photoacoustic microscopy
Title | Near‐infrared double‐illumination optical‐resolution photoacoustic microscopy |
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Authors | |
Issue Date | 2021 |
Publisher | Wiley-VCH Verlag. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/368 |
Citation | Journal of Biophotonics, 2021, v. 14 n. 3, p. article no. e202000392 How to Cite? |
Abstract | Label-free chemical bond imaging is of great importance in biology and medicine. Photoacoustic imaging at the third near-infrared windows (1600-1870 nm, near-infrared-III) provides a stable molecular vibrational imaging tool for lipid-rich tissue owing to the first overtone transition of the CH bond at 1.7 μm. However, lacking high-energy pulsed laser sources at 1.7 μm and the strong water absorption significantly limit the signal-to-noise ratio of the lipid imaging, especially for thin lipid tissues. To circumvent this barrier, we develop near-infrared-III double-illumination optical-resolution photoacoustic microscopy (DIOR-PAM) for improving the sensitivity of label-free lipid imaging. Using the same laser, DIOR-PAM can enhance the sensitivity by nearly 100%, which we prove in the Monte Carlo simulation. We experimentally demonstrated 50% ~ 100% sensitivity enhancements on nonbiological and biological lipid-rich samples. |
Persistent Identifier | http://hdl.handle.net/10722/303950 |
ISSN | 2021 Impact Factor: 3.390 2020 SCImago Journal Rankings: 0.877 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, M | - |
dc.contributor.author | Shi, J | - |
dc.contributor.author | Yiu, CCY | - |
dc.contributor.author | Li, C | - |
dc.contributor.author | Wong, KKY | - |
dc.contributor.author | Wang, L | - |
dc.date.accessioned | 2021-09-23T08:53:05Z | - |
dc.date.available | 2021-09-23T08:53:05Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Biophotonics, 2021, v. 14 n. 3, p. article no. e202000392 | - |
dc.identifier.issn | 1864-063X | - |
dc.identifier.uri | http://hdl.handle.net/10722/303950 | - |
dc.description.abstract | Label-free chemical bond imaging is of great importance in biology and medicine. Photoacoustic imaging at the third near-infrared windows (1600-1870 nm, near-infrared-III) provides a stable molecular vibrational imaging tool for lipid-rich tissue owing to the first overtone transition of the CH bond at 1.7 μm. However, lacking high-energy pulsed laser sources at 1.7 μm and the strong water absorption significantly limit the signal-to-noise ratio of the lipid imaging, especially for thin lipid tissues. To circumvent this barrier, we develop near-infrared-III double-illumination optical-resolution photoacoustic microscopy (DIOR-PAM) for improving the sensitivity of label-free lipid imaging. Using the same laser, DIOR-PAM can enhance the sensitivity by nearly 100%, which we prove in the Monte Carlo simulation. We experimentally demonstrated 50% ~ 100% sensitivity enhancements on nonbiological and biological lipid-rich samples. | - |
dc.language | eng | - |
dc.publisher | Wiley-VCH Verlag. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/368 | - |
dc.relation.ispartof | Journal of Biophotonics | - |
dc.rights | Journal of Biophotonics. Copyright © Wiley-VCH Verlag. | - |
dc.rights | Submitted (preprint) Version: This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions Accepted (peer-reviewed) Version: This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | - |
dc.title | Near‐infrared double‐illumination optical‐resolution photoacoustic microscopy | - |
dc.type | Article | - |
dc.identifier.email | Yiu, CCY: ccyyiu@hku.hk | - |
dc.identifier.email | Wong, KKY: kywong@eee.hku.hk | - |
dc.identifier.authority | Wong, KKY=rp00189 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jbio.202000392 | - |
dc.identifier.pmid | 33205905 | - |
dc.identifier.scopus | eid_2-s2.0-85096985038 | - |
dc.identifier.hkuros | 325298 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | article no. e202000392 | - |
dc.identifier.epage | article no. e202000392 | - |
dc.identifier.isi | WOS:000594584900001 | - |
dc.publisher.place | Germany | - |