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Article: Impact of short‐term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes

TitleImpact of short‐term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes
Authors
Issue Date2021
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2021, v. 35 n. 6, p. 3236-3245 How to Cite?
AbstractBilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which are powerful antioxidants and reported to have antiinflammatory, antidyslipidemic, antihypertensive, and hypoglycemic effects. The objective of this study was to assess the effect of bilberry supplementation on biomarkers of glycemic control, lipid profile, antioxidant, and inflammatory status in patients with type 2 diabetes in a randomized, double-blind, placebo-controlled cross-over study. Twenty patients were randomized to receive either bilberry supplementation (1.4 g/day of extract) daily for 4 weeks followed by 6 weeks of washout and then an additional 4 weeks of matching placebo or vice versa. Blood pressure, metabolic parameters, antioxidant status, and oxidative stress were measured before and after each period. Results showed no effect on body weight, blood pressure, or lipid profile. HbA1c was reduced by 0.31 ± 0.58% during bilberry supplementation, but this change was not significantly different from that with placebo. Antioxidant status, oxidative stress, and inflammatory status showed no significant differences across treatments. This short-term study of bilberry supplementation did not show significant effects on cardiovascular risk factors or antioxidant status, but the tendency for improved glycemic control may suggest a longer treatment period may be effective in diabetic patients.
Persistent Identifierhttp://hdl.handle.net/10722/303922
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.277
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCHAN, SW-
dc.contributor.authorCHU, TTW-
dc.contributor.authorChoi, SW-
dc.contributor.authorBENZIE, IFF-
dc.contributor.authorTOMLINSON, B-
dc.date.accessioned2021-09-23T08:52:39Z-
dc.date.available2021-09-23T08:52:39Z-
dc.date.issued2021-
dc.identifier.citationPhytotherapy Research, 2021, v. 35 n. 6, p. 3236-3245-
dc.identifier.issn0951-418X-
dc.identifier.urihttp://hdl.handle.net/10722/303922-
dc.description.abstractBilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which are powerful antioxidants and reported to have antiinflammatory, antidyslipidemic, antihypertensive, and hypoglycemic effects. The objective of this study was to assess the effect of bilberry supplementation on biomarkers of glycemic control, lipid profile, antioxidant, and inflammatory status in patients with type 2 diabetes in a randomized, double-blind, placebo-controlled cross-over study. Twenty patients were randomized to receive either bilberry supplementation (1.4 g/day of extract) daily for 4 weeks followed by 6 weeks of washout and then an additional 4 weeks of matching placebo or vice versa. Blood pressure, metabolic parameters, antioxidant status, and oxidative stress were measured before and after each period. Results showed no effect on body weight, blood pressure, or lipid profile. HbA1c was reduced by 0.31 ± 0.58% during bilberry supplementation, but this change was not significantly different from that with placebo. Antioxidant status, oxidative stress, and inflammatory status showed no significant differences across treatments. This short-term study of bilberry supplementation did not show significant effects on cardiovascular risk factors or antioxidant status, but the tendency for improved glycemic control may suggest a longer treatment period may be effective in diabetic patients.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567-
dc.relation.ispartofPhytotherapy Research-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.titleImpact of short‐term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes-
dc.typeArticle-
dc.identifier.emailChoi, SW: htswchoi@HKUCC-COM.hku.hk-
dc.identifier.authorityChoi, SW=rp02552-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.7038-
dc.identifier.pmid33599340-
dc.identifier.scopuseid_2-s2.0-85100880567-
dc.identifier.hkuros325345-
dc.identifier.volume35-
dc.identifier.issue6-
dc.identifier.spage3236-
dc.identifier.epage3245-
dc.identifier.isiWOS:000619121100001-
dc.publisher.placeUnited Kingdom-

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