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Article: Roles of enteric neural stem cell niche and enteric nervous system development in Hirschsprung disease

TitleRoles of enteric neural stem cell niche and enteric nervous system development in Hirschsprung disease
Authors
Keywordsenteric nervous system
enteric neural crest cells
neural stem cell niche
extra-cellular matrix
Hirschsprung disease
Issue Date2021
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2021, v. 22 n. 18, p. article no. 9659 How to Cite?
AbstractThe development of the enteric nervous system (ENS) is highly modulated by the synchronized interaction between the enteric neural crest cells (ENCCs) and the neural stem cell niche comprising the gut microenvironment. Genetic defects dysregulating the cellular behaviour(s) of the ENCCs result in incomplete innervation and hence ENS dysfunction. Hirschsprung disease (HSCR) is a rare complex neurocristopathy in which the enteric neural crest-derived cells fail to colonize the distal colon. In addition to ENS defects, increasing evidence suggests that HSCR patients may have intrinsic defects in the niche impairing the extracellular matrix (ECM)-cell interaction and/or dysregulating the cellular niche factors necessary for controlling stem cell behaviour. The niche defects in patients may compromise the regenerative capacity of the stem cell-based therapy and advocate for drug- and niche-based therapies as complementary therapeutic strategies to alleviate/enhance niche-cell interaction. Here, we provide a summary of the current understandings of the role of the enteric neural stem cell niche in modulating the development of the ENS and in the pathogenesis of HSCR. Deciphering the contribution of the niche to HSCR may provide important implications to the development of regenerative medicine for HSCR.
Persistent Identifierhttp://hdl.handle.net/10722/303904
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJi, Y-
dc.contributor.authorTam, PKH-
dc.contributor.authorTang, CSM-
dc.date.accessioned2021-09-23T08:52:23Z-
dc.date.available2021-09-23T08:52:23Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Molecular Sciences, 2021, v. 22 n. 18, p. article no. 9659-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/303904-
dc.description.abstractThe development of the enteric nervous system (ENS) is highly modulated by the synchronized interaction between the enteric neural crest cells (ENCCs) and the neural stem cell niche comprising the gut microenvironment. Genetic defects dysregulating the cellular behaviour(s) of the ENCCs result in incomplete innervation and hence ENS dysfunction. Hirschsprung disease (HSCR) is a rare complex neurocristopathy in which the enteric neural crest-derived cells fail to colonize the distal colon. In addition to ENS defects, increasing evidence suggests that HSCR patients may have intrinsic defects in the niche impairing the extracellular matrix (ECM)-cell interaction and/or dysregulating the cellular niche factors necessary for controlling stem cell behaviour. The niche defects in patients may compromise the regenerative capacity of the stem cell-based therapy and advocate for drug- and niche-based therapies as complementary therapeutic strategies to alleviate/enhance niche-cell interaction. Here, we provide a summary of the current understandings of the role of the enteric neural stem cell niche in modulating the development of the ENS and in the pathogenesis of HSCR. Deciphering the contribution of the niche to HSCR may provide important implications to the development of regenerative medicine for HSCR.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectenteric nervous system-
dc.subjectenteric neural crest cells-
dc.subjectneural stem cell niche-
dc.subjectextra-cellular matrix-
dc.subjectHirschsprung disease-
dc.titleRoles of enteric neural stem cell niche and enteric nervous system development in Hirschsprung disease-
dc.typeArticle-
dc.identifier.emailJi, Y: yj1214@HKUCC-COM.hku.hk-
dc.identifier.emailTam, PKH: paultam@hku.hk-
dc.identifier.emailTang, CSM: claratang@hku.hk-
dc.identifier.authorityTam, PKH=rp00060-
dc.identifier.authorityTang, CSM=rp02105-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms22189659-
dc.identifier.pmid34575824-
dc.identifier.pmcidPMC8465795-
dc.identifier.scopuseid_2-s2.0-85114378288-
dc.identifier.hkuros325197-
dc.identifier.volume22-
dc.identifier.issue18-
dc.identifier.spagearticle no. 9659-
dc.identifier.epagearticle no. 9659-
dc.identifier.isiWOS:000699499900001-
dc.publisher.placeSwitzerland-

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