File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community

TitlePrevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community
Authors
KeywordsCommunity prevalence
Methicillin-resistant Staphylococcus aureus
Carbapenemase
Extended spectrum beta-lactamase
Multidrug resistance
Issue Date2020
Citation
Journal of Infection, 2020, v. 81, n. 2, p. 242-247 How to Cite?
AbstractObjectives: We conducted a cross-sectional study in Hong Kong community to estimate the carriage prevalence, associated factors and genotypes of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA) and carbapenemase-producing Enterobacteriaceae (CPE). Methods: Seemingly healthy subjects were asked to provide nasal, handprint and stool samples from March to April 2017. Isolates were characterized by molecular methods. We used multivariable logistic regression models within a generalized estimating equation framework to identify risk factors for ESBL-E carriage. Characteristics of MRSA/CPE carriage were summarized. Results: The prevalence of ESBL-E, MRSA and CPE were 52.8% (104/197), 2.5% (5/197) and 0.5% (1/197) respectively. Most ESBL-E isolates were E. coli (85.6%; 113/132). Most ESBL genes belonged to blaCTX−M-G9 (68.9%) and blaTEM (53.0%) types. Self-reported antibiotic consumption (≥2 courses) in the past six months was associated with ESBL-E carriage (adjusted odds ratio: 4.71–5.47). Conclusions: Abundance of ESBL-E in the community are causes of concern, and antibiotic use is associated with its carriage. Presence of MRSA and CPE in community members without clear healthcare exposure hints on a change in their epidemiology. This study establishes a baseline to formulate infection control policies and future studies in combating antimicrobial resistance.
Persistent Identifierhttp://hdl.handle.net/10722/303677
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 2.669
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwok, Kin On-
dc.contributor.authorChan, Emily-
dc.contributor.authorChung, Pui Hong-
dc.contributor.authorTang, Arthur-
dc.contributor.authorWei, Wan In-
dc.contributor.authorZhu, Chendi-
dc.contributor.authorRiley, Steven-
dc.contributor.authorIp, Margaret-
dc.date.accessioned2021-09-15T08:25:48Z-
dc.date.available2021-09-15T08:25:48Z-
dc.date.issued2020-
dc.identifier.citationJournal of Infection, 2020, v. 81, n. 2, p. 242-247-
dc.identifier.issn0163-4453-
dc.identifier.urihttp://hdl.handle.net/10722/303677-
dc.description.abstractObjectives: We conducted a cross-sectional study in Hong Kong community to estimate the carriage prevalence, associated factors and genotypes of extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E), methicillin-resistant Staphylococcus aureus (MRSA) and carbapenemase-producing Enterobacteriaceae (CPE). Methods: Seemingly healthy subjects were asked to provide nasal, handprint and stool samples from March to April 2017. Isolates were characterized by molecular methods. We used multivariable logistic regression models within a generalized estimating equation framework to identify risk factors for ESBL-E carriage. Characteristics of MRSA/CPE carriage were summarized. Results: The prevalence of ESBL-E, MRSA and CPE were 52.8% (104/197), 2.5% (5/197) and 0.5% (1/197) respectively. Most ESBL-E isolates were E. coli (85.6%; 113/132). Most ESBL genes belonged to blaCTX−M-G9 (68.9%) and blaTEM (53.0%) types. Self-reported antibiotic consumption (≥2 courses) in the past six months was associated with ESBL-E carriage (adjusted odds ratio: 4.71–5.47). Conclusions: Abundance of ESBL-E in the community are causes of concern, and antibiotic use is associated with its carriage. Presence of MRSA and CPE in community members without clear healthcare exposure hints on a change in their epidemiology. This study establishes a baseline to formulate infection control policies and future studies in combating antimicrobial resistance.-
dc.languageeng-
dc.relation.ispartofJournal of Infection-
dc.subjectCommunity prevalence-
dc.subjectMethicillin-resistant Staphylococcus aureus-
dc.subjectCarbapenemase-
dc.subjectExtended spectrum beta-lactamase-
dc.subjectMultidrug resistance-
dc.titlePrevalence and associated factors for carriage of Enterobacteriaceae producing ESBLs or carbapenemase and methicillin-resistant Staphylococcus aureus in Hong Kong community-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jinf.2020.05.033-
dc.identifier.pmid32447008-
dc.identifier.scopuseid_2-s2.0-85086785894-
dc.identifier.volume81-
dc.identifier.issue2-
dc.identifier.spage242-
dc.identifier.epage247-
dc.identifier.eissn1532-2742-
dc.identifier.isiWOS:000553365200068-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats