File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.ijid.2007.12.018
- Scopus: eid_2-s2.0-67349126963
- PMID: 19019715
- WOS: WOS:000267878400010
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: A multi-country outbreak of fungal keratitis associated with a brand of contact lens solution: the Hong Kong experience
Title | A multi-country outbreak of fungal keratitis associated with a brand of contact lens solution: the Hong Kong experience |
---|---|
Authors | |
Keywords | Case-control study Contact lens Fungal keratitis Fusarium spp |
Issue Date | 2009 |
Citation | International Journal of Infectious Diseases, 2009, v. 13, n. 4, p. 443-448 How to Cite? |
Abstract | Objectives: Starting in mid-2005, an increase in fungal keratitis caused by Fusarium spp was observed among contact lens wearers in Hong Kong, Singapore, and the USA. The objective of this study was to describe the outbreak and to determine any association with the use of Bausch & Lomb (B&L) ReNu® contact lens solution. Methods: We defined a case as a disposable contact lens user with ophthalmologist-diagnosed keratitis and a positive culture of Fusarium spp reported to the Department of Health from January 1, 2005 to May 31, 2006. We identified cases through inpatient discharge data and the electronic laboratory databases of all public hospitals, and from physician reporting. Controls were recruited from three outpatient clinics. Risk factors were collected using a standardized questionnaire and analyzed by univariate analysis and binary logistic regression. Results: From January 2005 through May 2006, we identified 33 cases of Fusarium keratitis. Most were in young adults (mean age 28 years) who presented with eye pain (100%), redness (84%), photophobia (41%), and tearing (34%). Twenty-four cases and 86 controls were recruited in the case-control study. By logistic regression, B&L ReNu solution showed the strongest association with being a case (adjusted odds ratio 26.1, 95% confidence interval 3.0-225.3) after adjusting for potential confounders. Conclusion: Using B&L ReNu contact lens solution was strongly associated with Fusarium keratitis among disposable contact lens users in Hong Kong. B&L ReNu with MoistureLoc® was permanently withdrawn from the market globally in May 2006. Crown Copyright © 2008. |
Persistent Identifier | http://hdl.handle.net/10722/303337 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.435 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ma, Siu keung Edmond | - |
dc.contributor.author | So, Kellie | - |
dc.contributor.author | Chung, Pui hong | - |
dc.contributor.author | Tsang, Ho fai Thomas | - |
dc.contributor.author | Chuang, Shuk kwan | - |
dc.date.accessioned | 2021-09-15T08:25:06Z | - |
dc.date.available | 2021-09-15T08:25:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | International Journal of Infectious Diseases, 2009, v. 13, n. 4, p. 443-448 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | http://hdl.handle.net/10722/303337 | - |
dc.description.abstract | Objectives: Starting in mid-2005, an increase in fungal keratitis caused by Fusarium spp was observed among contact lens wearers in Hong Kong, Singapore, and the USA. The objective of this study was to describe the outbreak and to determine any association with the use of Bausch & Lomb (B&L) ReNu® contact lens solution. Methods: We defined a case as a disposable contact lens user with ophthalmologist-diagnosed keratitis and a positive culture of Fusarium spp reported to the Department of Health from January 1, 2005 to May 31, 2006. We identified cases through inpatient discharge data and the electronic laboratory databases of all public hospitals, and from physician reporting. Controls were recruited from three outpatient clinics. Risk factors were collected using a standardized questionnaire and analyzed by univariate analysis and binary logistic regression. Results: From January 2005 through May 2006, we identified 33 cases of Fusarium keratitis. Most were in young adults (mean age 28 years) who presented with eye pain (100%), redness (84%), photophobia (41%), and tearing (34%). Twenty-four cases and 86 controls were recruited in the case-control study. By logistic regression, B&L ReNu solution showed the strongest association with being a case (adjusted odds ratio 26.1, 95% confidence interval 3.0-225.3) after adjusting for potential confounders. Conclusion: Using B&L ReNu contact lens solution was strongly associated with Fusarium keratitis among disposable contact lens users in Hong Kong. B&L ReNu with MoistureLoc® was permanently withdrawn from the market globally in May 2006. Crown Copyright © 2008. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Infectious Diseases | - |
dc.subject | Case-control study | - |
dc.subject | Contact lens | - |
dc.subject | Fungal keratitis | - |
dc.subject | Fusarium spp | - |
dc.title | A multi-country outbreak of fungal keratitis associated with a brand of contact lens solution: the Hong Kong experience | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.ijid.2007.12.018 | - |
dc.identifier.pmid | 19019715 | - |
dc.identifier.scopus | eid_2-s2.0-67349126963 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 443 | - |
dc.identifier.epage | 448 | - |
dc.identifier.isi | WOS:000267878400010 | - |