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Article: Effect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion

TitleEffect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion
Authors
Keywordsbioactive glass
fluoride
prevention
caries
strontium
Issue Date2021
PublisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/materials/
Citation
Materials, 2021, v. 14 n. 16, p. article no. 4645 How to Cite?
AbstractThis study investigated the effect of strontium-doped bioactive glass (SBAG) on the formation of dental demineralized lesions. Materials and methods: The study materials were 48 sound human tooth specimens with both dentine and enamel, divided equally into four groups: Group 1 (SBAG), Group 2 (SBAG+Fluoride), Group 3 (Fluoride), and Group 4 (Water as control). After 14 days of pH cycling, the surface morphology of the specimens was observed by scanning electron microscopy. Crystal characteristics of the precipitates were assessed by X-ray diffraction (XRD). Micro-CT was used to measure the mineral loss and the depths of the demineralized lesions formed. Results: Exposure of collagen in inter-tubular areas in dentine was seen in the control group (Group 4) but not in Groups 1 to 3. In Group 2, there were obvious granular particles on the surface of the dentine. XRD revealed precipitation of apatites on the surface of the tooth specimens in Groups 1 to 3. The mean lesion depths in dentine were 81.80 µm, 30.68 µm, 39.04 µm, and 146.36 µm in Groups 1 to 4, respectively (p < 0.001). Lesions in enamel were only found in the control group. The mean mineral loss values in the dentine lesions were 1.25 g/cm3 , 0.88 g/cm3 , 0.87 g/cm3 , and 1.65 g/cm3 , in Groups 1 to 4, respectively (p < 0.001). Conclusion: Strontium-doped bioactive glass has a preventive effect on the formation of demineralized lesions in enamel and dentine.
Persistent Identifierhttp://hdl.handle.net/10722/302447
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.565
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDai, LL-
dc.contributor.authorMei, ML-
dc.contributor.authorChu, CH-
dc.contributor.authorZhao, IS-
dc.contributor.authorLo, ECM-
dc.date.accessioned2021-09-06T03:32:25Z-
dc.date.available2021-09-06T03:32:25Z-
dc.date.issued2021-
dc.identifier.citationMaterials, 2021, v. 14 n. 16, p. article no. 4645-
dc.identifier.issn1996-1944-
dc.identifier.urihttp://hdl.handle.net/10722/302447-
dc.description.abstractThis study investigated the effect of strontium-doped bioactive glass (SBAG) on the formation of dental demineralized lesions. Materials and methods: The study materials were 48 sound human tooth specimens with both dentine and enamel, divided equally into four groups: Group 1 (SBAG), Group 2 (SBAG+Fluoride), Group 3 (Fluoride), and Group 4 (Water as control). After 14 days of pH cycling, the surface morphology of the specimens was observed by scanning electron microscopy. Crystal characteristics of the precipitates were assessed by X-ray diffraction (XRD). Micro-CT was used to measure the mineral loss and the depths of the demineralized lesions formed. Results: Exposure of collagen in inter-tubular areas in dentine was seen in the control group (Group 4) but not in Groups 1 to 3. In Group 2, there were obvious granular particles on the surface of the dentine. XRD revealed precipitation of apatites on the surface of the tooth specimens in Groups 1 to 3. The mean lesion depths in dentine were 81.80 µm, 30.68 µm, 39.04 µm, and 146.36 µm in Groups 1 to 4, respectively (p < 0.001). Lesions in enamel were only found in the control group. The mean mineral loss values in the dentine lesions were 1.25 g/cm3 , 0.88 g/cm3 , 0.87 g/cm3 , and 1.65 g/cm3 , in Groups 1 to 4, respectively (p < 0.001). Conclusion: Strontium-doped bioactive glass has a preventive effect on the formation of demineralized lesions in enamel and dentine.-
dc.languageeng-
dc.publisherMDPIAG. The Journal's web site is located at http://www.mdpi.com/journal/materials/-
dc.relation.ispartofMaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectbioactive glass-
dc.subjectfluoride-
dc.subjectprevention-
dc.subjectcaries-
dc.subjectstrontium-
dc.titleEffect of Strontium-Doped Bioactive Glass on Preventing Formation of Demineralized Lesion-
dc.typeArticle-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.authorityChu, CH=rp00022-
dc.identifier.authorityLo, ECM=rp00015-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ma14164645-
dc.identifier.pmid34443169-
dc.identifier.pmcidPMC8399109-
dc.identifier.scopuseid_2-s2.0-85113347290-
dc.identifier.hkuros324822-
dc.identifier.volume14-
dc.identifier.issue16-
dc.identifier.spagearticle no. 4645-
dc.identifier.epagearticle no. 4645-
dc.identifier.isiWOS:000689379400001-
dc.publisher.placeSwitzerland-

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