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Article: Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs
Title | Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs |
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Authors | |
Issue Date | 2021 |
Publisher | Pacini Editore Srl. The Journal's web site is located at http://www.clinexprheumatol.org |
Citation | Clinical and Experimental Rheumatology, 2021, Epub 2021-07-24 How to Cite? |
Abstract | Objectives: To determine the risk of 6 types of malignancies in spondyloarthritis (SpA) with and without psoriasis (PsO) and on disease-modifying anti-rheumatic drugs (DMARDs), compared to non-specific back pain (NSBP).
Methods: Medical records were retrieved. Patients with SpA with and without PsO were identified and compared to those with NSBP. Clinical data; follow-up duration; comorbidities; dates and types of cancer diagnosed; types and duration of DMARD therapy were collected. Propensity score adjustment was used to compare the risks of malignancies between SpA, SpA with and without PsO, and NSBP. Cox regression analysis was used to determine the risk of malignancy in DMARD therapy.
Results: A total of 3020 patients with SpA and 2527 patients with NSBP were studied. The mean follow-up duration in patients with SpA and NSBP was 9.6 years and 13.5 years respectively. Incidence and risk of malignancies were compatible between SpA and NSBP. The incidences of various carcinomas (per 1000 patient-years) in SpA were: 1.37 for colorectal carcinoma; 0.30 for carcinoma of pancreas; 0.30 for carcinoma of stomach; and 0.91 for lymphomas. Risk of colorectal carcinoma (HR 2.46; p=0.03) and lymphomas (HR 2.86; p=0.04) was increased in SpA with concomitant PsO. DMARD therapy was not associated with increased risks of malignancies after adjustment for confounding factors.
Conclusions: Risk of malignancy was increased in SpA with PsO but not in other subtypes of SpA or DMARD therapy. |
Persistent Identifier | http://hdl.handle.net/10722/302077 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 0.907 |
DC Field | Value | Language |
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dc.contributor.author | Chung, HY | - |
dc.contributor.author | Chan, SCW | - |
dc.contributor.author | Chui, ETF | - |
dc.contributor.author | Yau, T | - |
dc.contributor.author | Lau, CS | - |
dc.date.accessioned | 2021-08-21T03:31:15Z | - |
dc.date.available | 2021-08-21T03:31:15Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Clinical and Experimental Rheumatology, 2021, Epub 2021-07-24 | - |
dc.identifier.issn | 0392-856X | - |
dc.identifier.uri | http://hdl.handle.net/10722/302077 | - |
dc.description.abstract | Objectives: To determine the risk of 6 types of malignancies in spondyloarthritis (SpA) with and without psoriasis (PsO) and on disease-modifying anti-rheumatic drugs (DMARDs), compared to non-specific back pain (NSBP). Methods: Medical records were retrieved. Patients with SpA with and without PsO were identified and compared to those with NSBP. Clinical data; follow-up duration; comorbidities; dates and types of cancer diagnosed; types and duration of DMARD therapy were collected. Propensity score adjustment was used to compare the risks of malignancies between SpA, SpA with and without PsO, and NSBP. Cox regression analysis was used to determine the risk of malignancy in DMARD therapy. Results: A total of 3020 patients with SpA and 2527 patients with NSBP were studied. The mean follow-up duration in patients with SpA and NSBP was 9.6 years and 13.5 years respectively. Incidence and risk of malignancies were compatible between SpA and NSBP. The incidences of various carcinomas (per 1000 patient-years) in SpA were: 1.37 for colorectal carcinoma; 0.30 for carcinoma of pancreas; 0.30 for carcinoma of stomach; and 0.91 for lymphomas. Risk of colorectal carcinoma (HR 2.46; p=0.03) and lymphomas (HR 2.86; p=0.04) was increased in SpA with concomitant PsO. DMARD therapy was not associated with increased risks of malignancies after adjustment for confounding factors. Conclusions: Risk of malignancy was increased in SpA with PsO but not in other subtypes of SpA or DMARD therapy. | - |
dc.language | eng | - |
dc.publisher | Pacini Editore Srl. The Journal's web site is located at http://www.clinexprheumatol.org | - |
dc.relation.ispartof | Clinical and Experimental Rheumatology | - |
dc.title | Malignancies in spondyloarthritis with and without concomitant psoriasis, and the effect of disease modifying anti-rheumatic drugs | - |
dc.type | Article | - |
dc.identifier.email | Chung, HY: jameschy@hku.hk | - |
dc.identifier.email | Yau, T: tyaucc@hku.hk | - |
dc.identifier.email | Lau, CS: cslau@hku.hk | - |
dc.identifier.authority | Chung, HY=rp02330 | - |
dc.identifier.authority | Yau, T=rp01466 | - |
dc.identifier.authority | Lau, CS=rp01348 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 34369368 | - |
dc.identifier.hkuros | 324203 | - |
dc.identifier.volume | Epub 2021-07-24 | - |
dc.publisher.place | Italy | - |