File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: LncRNA diGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors

TitleLncRNA diGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors
Authors
KeywordsLncRNA
DGCR5
Regulation mechanism
Diagnostic marker
Liquid biopsy
Issue Date2021
PublisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha
Citation
Biomedicine & Pharmacotherapy, 2021, v. 141, p. article no. 111889 How to Cite?
AbstractLong non-coding RNA (lncRNA), a subgroup of ncRNA with a length of more than 200 nt without protein coding function, has been recognized by the academia for its mediating effects of dysregulated expression on the tumorigenesis and development of a variety of tumors. LncRNA DiGeorge syndrome critical region gene 5 (DGCR5), originally found to induce DiGeorge syndrome, has been confirmed to be extremely dysregulated in multiple tumors, which mediates the malignant phenotypes of hepatocellular carcinoma, pancreatic cancer, lung cancer, etc. through the regulation of Wnt/β-catenin, MEK/ERK1/2 and other cancerous signaling pathways as a molecular sponge. Researches on the cancerous derivation-related pathways involved in DGCR5 can provide potential molecular intervention targets for tumor precision treatment. Moreover, liquid biopsy based on the detection of DGCR5 in body fluids is also expected to provide a non-invasive evaluation method for the early diagnosis and prognostic evaluation of malignant tumors.
Persistent Identifierhttp://hdl.handle.net/10722/301971
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.493
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, H-
dc.contributor.authorHuang, Z-
dc.contributor.authorLiu, S-
dc.contributor.authorZhao, X-
dc.contributor.authorHe, R-
dc.contributor.authorWang, Z-
dc.contributor.authorShi, W-
dc.contributor.authorChen, W-
dc.contributor.authorLi, Z-
dc.contributor.authorYu, L-
dc.contributor.authorHuang, P-
dc.contributor.authorKang, P-
dc.contributor.authorSu, Z-
dc.contributor.authorXu, Y-
dc.contributor.authorYam, JWP-
dc.contributor.authorCiu, Y-
dc.date.accessioned2021-08-21T03:29:40Z-
dc.date.available2021-08-21T03:29:40Z-
dc.date.issued2021-
dc.identifier.citationBiomedicine & Pharmacotherapy, 2021, v. 141, p. article no. 111889-
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/10722/301971-
dc.description.abstractLong non-coding RNA (lncRNA), a subgroup of ncRNA with a length of more than 200 nt without protein coding function, has been recognized by the academia for its mediating effects of dysregulated expression on the tumorigenesis and development of a variety of tumors. LncRNA DiGeorge syndrome critical region gene 5 (DGCR5), originally found to induce DiGeorge syndrome, has been confirmed to be extremely dysregulated in multiple tumors, which mediates the malignant phenotypes of hepatocellular carcinoma, pancreatic cancer, lung cancer, etc. through the regulation of Wnt/β-catenin, MEK/ERK1/2 and other cancerous signaling pathways as a molecular sponge. Researches on the cancerous derivation-related pathways involved in DGCR5 can provide potential molecular intervention targets for tumor precision treatment. Moreover, liquid biopsy based on the detection of DGCR5 in body fluids is also expected to provide a non-invasive evaluation method for the early diagnosis and prognostic evaluation of malignant tumors.-
dc.languageeng-
dc.publisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha-
dc.relation.ispartofBiomedicine & Pharmacotherapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLncRNA-
dc.subjectDGCR5-
dc.subjectRegulation mechanism-
dc.subjectDiagnostic marker-
dc.subjectLiquid biopsy-
dc.titleLncRNA diGeorge syndrome critical region gene 5: A crucial regulator in malignant tumors-
dc.typeArticle-
dc.identifier.emailYam, JWP: judyyam@pathology.hku.hk-
dc.identifier.authorityYam, JWP=rp00468-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.biopha.2021.111889-
dc.identifier.pmid34323697-
dc.identifier.scopuseid_2-s2.0-85109660074-
dc.identifier.hkuros324195-
dc.identifier.volume141-
dc.identifier.spagearticle no. 111889-
dc.identifier.epagearticle no. 111889-
dc.identifier.isiWOS:000693006700004-
dc.publisher.placeFrance-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats