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- Publisher Website: 10.1038/s41467-019-09111-2
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- PMID: 30918256
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Article: Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions
Title | Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions |
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Authors | Olivé, MontseEngvall, MartinRavenscroft, GianinaCabrera-Serrano, MacarenaJiao, HongBortolotti, Carlo AugustoPignataro, MarcelloLambrughi, MatteoJiang, HaiboForrest, Alistair R.R.Benseny-Cases, NúriaHofbauer, StefanObinger, ChristianBattistuzzi, GianantonioBellei, MarziaBorsari, MarcoDi Rocco, GiuliaViola, Helena M.Hool, Livia C.Cladera, JosepLagerstedt-Robinson, KristinaXiang, FengqingWredenberg, AnnaMiralles, FrancescBaiges, Juan JoséMalfatti, EdoardoRomero, Norma B.Streichenberger, NathalieVial, ChristopheClaeys, Kristl G.Straathof, Chiara S.M.Goris, AnFreyer, ChristophLammens, MartinBassez, GuillaumeKere, JuhaClemente, PaulaSejersen, ThomasUdd, BjarneVidal, NoemíFerrer, IsidreEdström, LarsWedell, AnnaLaing, Nigel G. |
Issue Date | 2019 |
Citation | Nature Communications, 2019, v. 10, article no. 1396 How to Cite? |
Abstract | Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O 2, facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.292C>T (p.His98Tyr) substitution in MB in fourteen members of six European families suffering from an autosomal dominant progressive myopathy with highly characteristic sarcoplasmic inclusions in skeletal and cardiac muscle. Myoglobinopathy manifests in adulthood with proximal and axial weakness that progresses to involve distal muscles and causes respiratory and cardiac failure. Biochemical characterization reveals that the mutant myoglobin has altered O 2 binding, exhibits a faster heme dissociation rate and has a lower reduction potential compared to wild-type myoglobin. Preliminary studies show that mutant myoglobin may result in elevated superoxide levels at the cellular level. These data define a recognizable muscle disease associated with MB mutation. |
Persistent Identifier | http://hdl.handle.net/10722/301837 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Olivé, Montse | - |
dc.contributor.author | Engvall, Martin | - |
dc.contributor.author | Ravenscroft, Gianina | - |
dc.contributor.author | Cabrera-Serrano, Macarena | - |
dc.contributor.author | Jiao, Hong | - |
dc.contributor.author | Bortolotti, Carlo Augusto | - |
dc.contributor.author | Pignataro, Marcello | - |
dc.contributor.author | Lambrughi, Matteo | - |
dc.contributor.author | Jiang, Haibo | - |
dc.contributor.author | Forrest, Alistair R.R. | - |
dc.contributor.author | Benseny-Cases, Núria | - |
dc.contributor.author | Hofbauer, Stefan | - |
dc.contributor.author | Obinger, Christian | - |
dc.contributor.author | Battistuzzi, Gianantonio | - |
dc.contributor.author | Bellei, Marzia | - |
dc.contributor.author | Borsari, Marco | - |
dc.contributor.author | Di Rocco, Giulia | - |
dc.contributor.author | Viola, Helena M. | - |
dc.contributor.author | Hool, Livia C. | - |
dc.contributor.author | Cladera, Josep | - |
dc.contributor.author | Lagerstedt-Robinson, Kristina | - |
dc.contributor.author | Xiang, Fengqing | - |
dc.contributor.author | Wredenberg, Anna | - |
dc.contributor.author | Miralles, Francesc | - |
dc.contributor.author | Baiges, Juan José | - |
dc.contributor.author | Malfatti, Edoardo | - |
dc.contributor.author | Romero, Norma B. | - |
dc.contributor.author | Streichenberger, Nathalie | - |
dc.contributor.author | Vial, Christophe | - |
dc.contributor.author | Claeys, Kristl G. | - |
dc.contributor.author | Straathof, Chiara S.M. | - |
dc.contributor.author | Goris, An | - |
dc.contributor.author | Freyer, Christoph | - |
dc.contributor.author | Lammens, Martin | - |
dc.contributor.author | Bassez, Guillaume | - |
dc.contributor.author | Kere, Juha | - |
dc.contributor.author | Clemente, Paula | - |
dc.contributor.author | Sejersen, Thomas | - |
dc.contributor.author | Udd, Bjarne | - |
dc.contributor.author | Vidal, Noemí | - |
dc.contributor.author | Ferrer, Isidre | - |
dc.contributor.author | Edström, Lars | - |
dc.contributor.author | Wedell, Anna | - |
dc.contributor.author | Laing, Nigel G. | - |
dc.date.accessioned | 2021-08-19T02:20:50Z | - |
dc.date.available | 2021-08-19T02:20:50Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nature Communications, 2019, v. 10, article no. 1396 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301837 | - |
dc.description.abstract | Myoglobin, encoded by MB, is a small cytoplasmic globular hemoprotein highly expressed in cardiac myocytes and oxidative skeletal myofibers. Myoglobin binds O 2, facilitates its intracellular transport and serves as a controller of nitric oxide and reactive oxygen species. Here, we identify a recurrent c.292C>T (p.His98Tyr) substitution in MB in fourteen members of six European families suffering from an autosomal dominant progressive myopathy with highly characteristic sarcoplasmic inclusions in skeletal and cardiac muscle. Myoglobinopathy manifests in adulthood with proximal and axial weakness that progresses to involve distal muscles and causes respiratory and cardiac failure. Biochemical characterization reveals that the mutant myoglobin has altered O 2 binding, exhibits a faster heme dissociation rate and has a lower reduction potential compared to wild-type myoglobin. Preliminary studies show that mutant myoglobin may result in elevated superoxide levels at the cellular level. These data define a recognizable muscle disease associated with MB mutation. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-019-09111-2 | - |
dc.identifier.pmid | 30918256 | - |
dc.identifier.pmcid | PMC6437160 | - |
dc.identifier.scopus | eid_2-s2.0-85063585616 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | article no. 1396 | - |
dc.identifier.epage | article no. 1396 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000462458900011 | - |