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Article: High-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis

TitleHigh-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis
Authors
Jiang, HaiboPassarelli, Melissa K.Munro, Peter M.G.Kilburn, Matt R.West, AndrewDollery, Colin T.Gilmore, Ian S.Rakowska, Paulina D.
Issue Date2017
Citation
Chemical Communications, 2017, v. 53, n. 9, p. 1506-1509 How to Cite?
DOI: http://dx.doi.org/10.1039/c6cc08549k
AbstractCorrelative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced phospholipidosis. Chemical fixation using tannic acid effectively seals cellular membranes aiding intracellular retention of diffusible drugs.
Persistent Identifierhttp://hdl.handle.net/10722/301809
ISSN
1359-7345
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.133
ISI Accession Number ID
WOS:000394937400014

 

DC FieldValueLanguage
dc.contributor.authorJiang, Haibo-
dc.contributor.authorPassarelli, Melissa K.-
dc.contributor.authorMunro, Peter M.G.-
dc.contributor.authorKilburn, Matt R.-
dc.contributor.authorWest, Andrew-
dc.contributor.authorDollery, Colin T.-
dc.contributor.authorGilmore, Ian S.-
dc.contributor.authorRakowska, Paulina D.-
dc.date.accessioned2021-08-19T02:20:47Z-
dc.date.available2021-08-19T02:20:47Z-
dc.date.issued2017-
dc.identifier.citationChemical Communications, 2017, v. 53, n. 9, p. 1506-1509-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10722/301809-
dc.description.abstractCorrelative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced phospholipidosis. Chemical fixation using tannic acid effectively seals cellular membranes aiding intracellular retention of diffusible drugs.-
dc.languageeng-
dc.relation.ispartofChemical Communications-
dc.titleHigh-resolution sub-cellular imaging by correlative NanoSIMS and electron microscopy of amiodarone internalisation by lung macrophages as evidence for drug-induced phospholipidosis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c6cc08549k-
dc.identifier.pmid28085162-
dc.identifier.scopuseid_2-s2.0-85010756266-
dc.identifier.volume53-
dc.identifier.issue9-
dc.identifier.spage1506-
dc.identifier.epage1509-
dc.identifier.eissn1364-548X-
dc.identifier.isiWOS:000394937400014-

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