File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3389/fnins.2019.01415
- Scopus: eid_2-s2.0-85079055116
- PMID: 32038130
- WOS: WOS:000511362700001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na+, K+, Mg2 +, Ca2 +, Cl–) Within Brain Tissue
Title | A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na<sup>+</sup>, K<sup>+</sup>, Mg<sup>2 +</sup>, Ca<sup>2 +</sup>, Cl<sup>–</sup>) Within Brain Tissue |
---|---|
Authors | |
Keywords | SIMS LA-ICP-MS metabolism PIXE ischemia microprobe imaging XFM |
Issue Date | 2020 |
Citation | Frontiers in Neuroscience, 2020, v. 13, article no. 1415 How to Cite? |
Abstract | Diffusible ions (Na+, K+, Mg2+, Ca2+, Cl–) are vital for healthy function of all cells, especially brain cells. Unfortunately, the diffusible nature of these ions renders them difficult to study with traditional microscopy in situ within ex vivo brain tissue sections. This mini-review examines the recent progress in the field, using direct elemental mapping techniques to study ion homeostasis during normal brain physiology and pathophysiology, through measurement of ion distribution and concentration in ex vivo brain tissue sections. The mini-review examines the advantages and limitations of specific techniques: proton induced X-ray emission (PIXE), X-ray fluorescence microscopy (XFM), secondary ion mass spectrometry (SIMS), laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), and the sample preparation requirements to study diffusible ions with these methods. |
Persistent Identifier | http://hdl.handle.net/10722/301783 |
ISSN | 2023 SCImago Journal Rankings: 1.063 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hartnell, David | - |
dc.contributor.author | Andrews, Wendy | - |
dc.contributor.author | Smith, Nicole | - |
dc.contributor.author | Jiang, Haibo | - |
dc.contributor.author | McAllum, Erin | - |
dc.contributor.author | Rajan, Ramesh | - |
dc.contributor.author | Colbourne, Frederick | - |
dc.contributor.author | Fitzgerald, Melinda | - |
dc.contributor.author | Lam, Virginie | - |
dc.contributor.author | Takechi, Ryusuke | - |
dc.contributor.author | Pushie, M. Jake | - |
dc.contributor.author | Kelly, Michael E. | - |
dc.contributor.author | Hackett, Mark J. | - |
dc.date.accessioned | 2021-08-19T02:20:43Z | - |
dc.date.available | 2021-08-19T02:20:43Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Neuroscience, 2020, v. 13, article no. 1415 | - |
dc.identifier.issn | 1662-4548 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301783 | - |
dc.description.abstract | Diffusible ions (Na+, K+, Mg2+, Ca2+, Cl–) are vital for healthy function of all cells, especially brain cells. Unfortunately, the diffusible nature of these ions renders them difficult to study with traditional microscopy in situ within ex vivo brain tissue sections. This mini-review examines the recent progress in the field, using direct elemental mapping techniques to study ion homeostasis during normal brain physiology and pathophysiology, through measurement of ion distribution and concentration in ex vivo brain tissue sections. The mini-review examines the advantages and limitations of specific techniques: proton induced X-ray emission (PIXE), X-ray fluorescence microscopy (XFM), secondary ion mass spectrometry (SIMS), laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS), and the sample preparation requirements to study diffusible ions with these methods. | - |
dc.language | eng | - |
dc.relation.ispartof | Frontiers in Neuroscience | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | SIMS | - |
dc.subject | LA-ICP-MS | - |
dc.subject | metabolism | - |
dc.subject | PIXE | - |
dc.subject | ischemia | - |
dc.subject | microprobe | - |
dc.subject | imaging | - |
dc.subject | XFM | - |
dc.title | A Review of ex vivo Elemental Mapping Methods to Directly Image Changes in the Homeostasis of Diffusible Ions (Na<sup>+</sup>, K<sup>+</sup>, Mg<sup>2 +</sup>, Ca<sup>2 +</sup>, Cl<sup>–</sup>) Within Brain Tissue | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fnins.2019.01415 | - |
dc.identifier.pmid | 32038130 | - |
dc.identifier.pmcid | PMC6987141 | - |
dc.identifier.scopus | eid_2-s2.0-85079055116 | - |
dc.identifier.volume | 13 | - |
dc.identifier.spage | article no. 1415 | - |
dc.identifier.epage | article no. 1415 | - |
dc.identifier.eissn | 1662-453X | - |
dc.identifier.isi | WOS:000511362700001 | - |