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- Publisher Website: 10.1021/jacs.1c02382
- Scopus: eid_2-s2.0-85106385686
- PMID: 33979146
- WOS: WOS:000657212800026
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Article: Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms
Title | Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms |
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Authors | |
Issue Date | 2021 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html |
Citation | Journal of the American Chemical Society, 2021, v. 143 n. 20, p. 7808-7818 How to Cite? |
Abstract | The homogeneously glycosylated 76-amino acid adiponectin collagenous domains (ACDs) with all of the possible 15 glycoforms have been chemically and individually synthesized using stereoselective glycan synthesis and chemical peptide ligation. The following biological and pharmacological studies enabled correlating glycan pattern to function in the inhibition of cancer cell growth as well as the regulation of systemic energy metabolism. In particular, hAdn-WM6877 was tested in detail with different mouse models and it exhibited promising in vivo antitumor, insulin sensitizing, and hepatoprotective activities. Our studies demonstrated the possibility of using synthetic glycopeptides as the adiponectin downsized mimetic for the development of novel therapeutics to treat diseases associated with deficient adiponectin. |
Persistent Identifier | http://hdl.handle.net/10722/301479 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID | |
Errata |
DC Field | Value | Language |
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dc.contributor.author | WU, H | - |
dc.contributor.author | ZHANG, Y | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Xu, J | - |
dc.contributor.author | Wang, Y | - |
dc.contributor.author | Li, X | - |
dc.date.accessioned | 2021-07-27T08:11:41Z | - |
dc.date.available | 2021-07-27T08:11:41Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2021, v. 143 n. 20, p. 7808-7818 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/301479 | - |
dc.description.abstract | The homogeneously glycosylated 76-amino acid adiponectin collagenous domains (ACDs) with all of the possible 15 glycoforms have been chemically and individually synthesized using stereoselective glycan synthesis and chemical peptide ligation. The following biological and pharmacological studies enabled correlating glycan pattern to function in the inhibition of cancer cell growth as well as the regulation of systemic energy metabolism. In particular, hAdn-WM6877 was tested in detail with different mouse models and it exhibited promising in vivo antitumor, insulin sensitizing, and hepatoprotective activities. Our studies demonstrated the possibility of using synthetic glycopeptides as the adiponectin downsized mimetic for the development of novel therapeutics to treat diseases associated with deficient adiponectin. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/jacsat/index.html | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.title | Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms | - |
dc.type | Article | - |
dc.identifier.email | Wang, Y: yuwanghk@hku.hk | - |
dc.identifier.email | Li, X: xuechenl@hku.hk | - |
dc.identifier.authority | Wang, Y=rp00239 | - |
dc.identifier.authority | Li, X=rp00742 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/jacs.1c02382 | - |
dc.identifier.pmid | 33979146 | - |
dc.identifier.scopus | eid_2-s2.0-85106385686 | - |
dc.identifier.hkuros | 323620 | - |
dc.identifier.volume | 143 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 7808 | - |
dc.identifier.epage | 7818 | - |
dc.identifier.isi | WOS:000657212800026 | - |
dc.publisher.place | United States | - |
dc.relation.erratum | doi:10.1021/jacs.1c05501 | - |