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Article: Development of DHQ-based chemical biology probe to profile cellular targets for HBV

TitleDevelopment of DHQ-based chemical biology probe to profile cellular targets for HBV
Authors
Zhang, QHuang, JChow, HYWang, JZhang, YFung, YMERen, QLi, X
KeywordsHepatitis B virus (HBV)
Dihydroquinolizinone (DHQ)
Activity-based proteome profiling (ABPP)
Photoaffinity labeling
RNA stability
Issue Date2020
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl
Citation
Bioorganic & Medicinal Chemistry Letters, 2020, v. 30 n. 23, p. article no. 127615 How to Cite?
DOI: http://dx.doi.org/10.1016/j.bmcl.2020.127615
AbstractChronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.
Persistent Identifierhttp://hdl.handle.net/10722/301378
ISSN
0960-894X
2021 Impact Factor: 2.940
2020 SCImago Journal Rankings: 0.617
ISI Accession Number ID
WOS:000595004500004

 

DC FieldValueLanguage
dc.contributor.authorZhang, Q-
dc.contributor.authorHuang, J-
dc.contributor.authorChow, HY-
dc.contributor.authorWang, J-
dc.contributor.authorZhang, Y-
dc.contributor.authorFung, YME-
dc.contributor.authorRen, Q-
dc.contributor.authorLi, X-
dc.date.accessioned2021-07-27T08:10:10Z-
dc.date.available2021-07-27T08:10:10Z-
dc.date.issued2020-
dc.identifier.citationBioorganic & Medicinal Chemistry Letters, 2020, v. 30 n. 23, p. article no. 127615-
dc.identifier.issn0960-894X-
dc.identifier.urihttp://hdl.handle.net/10722/301378-
dc.description.abstractChronic hepatitis B virus (HBV) infection has been a serious public health burden worldwide. Current anti-HBV therapies could not eliminate HBV ultimately. Considering the characteristics of HBV, it is impossible to be entirely cured based on current therapies. Therefore, it is urgently needed to develop novel therapeutic agents with new mechanism of action. The dihydroquinolizinone (DHQ) derivatives exhibited potent anti-HBV activity by decreasing HBV DNA and HBsAg level in an obscure mechanism of action. In this study, we have optimized the DHQ scaffold, developed the photoaffinity probe, with which to identify potential binding proteins.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl-
dc.relation.ispartofBioorganic & Medicinal Chemistry Letters-
dc.subjectHepatitis B virus (HBV)-
dc.subjectDihydroquinolizinone (DHQ)-
dc.subjectActivity-based proteome profiling (ABPP)-
dc.subjectPhotoaffinity labeling-
dc.subjectRNA stability-
dc.titleDevelopment of DHQ-based chemical biology probe to profile cellular targets for HBV-
dc.typeArticle-
dc.identifier.emailChow, HY: hchowhy@connect.hku.hk-
dc.identifier.emailWang, J: wangjz@hku.hk-
dc.identifier.emailFung, YME: eva.fungym@hku.hk-
dc.identifier.emailLi, X: xuechenl@hku.hk-
dc.identifier.authorityZhang, Q=rp02542-
dc.identifier.authorityFung, YME=rp01986-
dc.identifier.authorityLi, X=rp00742-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bmcl.2020.127615-
dc.identifier.pmid33080351-
dc.identifier.scopuseid_2-s2.0-85093955319-
dc.identifier.hkuros323616-
dc.identifier.volume30-
dc.identifier.issue23-
dc.identifier.spagearticle no. 127615-
dc.identifier.epagearticle no. 127615-
dc.identifier.isiWOS:000595004500004-
dc.publisher.placeUnited Kingdom-

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