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Article: The first case study of wastewater-based epidemiology of COVID-19 in Hong Kong

TitleThe first case study of wastewater-based epidemiology of COVID-19 in Hong Kong
Authors
KeywordsSewage surveillance
SARS-CoV-2
COVID-19
Sewage system characteristics
Early warnings
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenv
Citation
Science of the Total Environment, 2021, v. 790, p. article no. 148000 How to Cite?
AbstractEarly detection and surveillance of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus are key pre-requisites for the effective control of coronavirus disease (COVID-19). So far, sewage testing has been increasingly employed as an alternative surveillance tool for this disease. However, sampling site characteristics impact the testing results and should be addressed in the early use stage of this emerging tool. In this study, we implemented the sewage testing for SARS-CoV-2 virus across sampling sites with different sewage system characteristics. We first validated a testing method using “positive” samples from a hospital treating COVID-19 patients. This method was used to test 107 sewage samples collected during the third wave of the COVID-19 outbreak in Hong Kong (from June 8 to September 29, 2020), covering sampling sites associated with a COVID-19 hospital, public housing estates, and conventional sewage treatment facilities. The highest viral titer of 1975 copy/mL in sewage was observed in a sample collected from the isolation ward of the COVID-19 hospital. Sewage sampling at individual buildings detected the virus 2 days before the first cases were identified. Sequencing of the detected viral fragment confirmed an identical nucleotide sequence to that of the SARS-CoV-2 isolated from human samples. The virus was also detected in sewage treatment facilities, which serve populations of approximately 40,000 to more than one million people.
Persistent Identifierhttp://hdl.handle.net/10722/301371
ISSN
2023 Impact Factor: 8.2
2023 SCImago Journal Rankings: 1.998
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, X-
dc.contributor.authorZheng, X-
dc.contributor.authorLi, S-
dc.contributor.authorLam, NS-
dc.contributor.authorWang, Y-
dc.contributor.authorChu, DKW-
dc.contributor.authorPoon, LLM-
dc.contributor.authorTun, HM-
dc.contributor.authorPeiris, M-
dc.contributor.authorDeng, Y-
dc.contributor.authorLeung, GM-
dc.contributor.authorZhang, T-
dc.date.accessioned2021-07-27T08:10:05Z-
dc.date.available2021-07-27T08:10:05Z-
dc.date.issued2021-
dc.identifier.citationScience of the Total Environment, 2021, v. 790, p. article no. 148000-
dc.identifier.issn0048-9697-
dc.identifier.urihttp://hdl.handle.net/10722/301371-
dc.description.abstractEarly detection and surveillance of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus are key pre-requisites for the effective control of coronavirus disease (COVID-19). So far, sewage testing has been increasingly employed as an alternative surveillance tool for this disease. However, sampling site characteristics impact the testing results and should be addressed in the early use stage of this emerging tool. In this study, we implemented the sewage testing for SARS-CoV-2 virus across sampling sites with different sewage system characteristics. We first validated a testing method using “positive” samples from a hospital treating COVID-19 patients. This method was used to test 107 sewage samples collected during the third wave of the COVID-19 outbreak in Hong Kong (from June 8 to September 29, 2020), covering sampling sites associated with a COVID-19 hospital, public housing estates, and conventional sewage treatment facilities. The highest viral titer of 1975 copy/mL in sewage was observed in a sample collected from the isolation ward of the COVID-19 hospital. Sewage sampling at individual buildings detected the virus 2 days before the first cases were identified. Sequencing of the detected viral fragment confirmed an identical nucleotide sequence to that of the SARS-CoV-2 isolated from human samples. The virus was also detected in sewage treatment facilities, which serve populations of approximately 40,000 to more than one million people.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenv-
dc.relation.ispartofScience of the Total Environment-
dc.subjectSewage surveillance-
dc.subjectSARS-CoV-2-
dc.subjectCOVID-19-
dc.subjectSewage system characteristics-
dc.subjectEarly warnings-
dc.titleThe first case study of wastewater-based epidemiology of COVID-19 in Hong Kong-
dc.typeArticle-
dc.identifier.emailChu, DKW: dkwchu@hku.hk-
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hk-
dc.identifier.emailTun, HM: heinmtun@hku.hk-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.emailDeng, Y: dengyu@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailZhang, T: zhangt@hkucc.hku.hk-
dc.identifier.authorityChu, DKW=rp02512-
dc.identifier.authorityPoon, LLM=rp00484-
dc.identifier.authorityTun, HM=rp02389-
dc.identifier.authorityPeiris, M=rp00410-
dc.identifier.authorityDeng, Y=rp02795-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityZhang, T=rp00211-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.scitotenv.2021.148000-
dc.identifier.pmid34091338-
dc.identifier.pmcidPMC8142803-
dc.identifier.scopuseid_2-s2.0-85107649730-
dc.identifier.hkuros323434-
dc.identifier.volume790-
dc.identifier.spagearticle no. 148000-
dc.identifier.epagearticle no. 148000-
dc.identifier.isiWOS:000684999300010-
dc.publisher.placeNetherlands-

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