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Article: Enamel-like tissue regeneration by using biomimetic enamel matrix proteins

TitleEnamel-like tissue regeneration by using biomimetic enamel matrix proteins
Authors
KeywordsBiomimetic regeneration
Enamel
Extracellular matrix proteins
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijbiomac
Citation
International Journal of Biological Macromolecules, 2021, v. 183, p. 2131-2141 How to Cite?
AbstractEnamel regeneration currently -is limited by our inability to duplicate artificially its complicated and well-aligned hydroxyapatite structure. The initial formation of enamel occurs in enamel organs where the ameloblasts secret enamel extracellular matrix formed a unique gel-like microenvironment. The enamel extracellular matrix is mainly composed by amelogenin and non-amelogenin. In this study, an innovative strategy was proposed to regenerate enamel-like tissue by constructing a microenvironment using biomimetic enamel matrix proteins (biomimetic EMPs) composed of modified leucine-rich amelogenin peptide (mLRAP) and non-amelogenin analog (NAA). Impressively, the regenerated enamel in this biomimetic EMPs on etched enamel surface produced prismatic structures, and showed similar mechanical properties to natural enamel. The results of X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) showed that regenerated crystal was hydroxyapatite. Molecular dynamics simulation analysis showed the binding energy between mLRAP and NAA were electrostatic forces and Van der Walls. These results introduced a promising strategy to induce crystal growth of enamel-like hydroxyapatite for biomimetic reproduction of materials with complicated hierarchical microstructures.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/301248
ISSN
2023 Impact Factor: 7.7
2023 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFang, Z-
dc.contributor.authorGuo, M-
dc.contributor.authorZhou, Q-
dc.contributor.authorLi, Q-
dc.contributor.authorWong, HM-
dc.contributor.authorCao, CY-
dc.date.accessioned2021-07-27T08:08:18Z-
dc.date.available2021-07-27T08:08:18Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Biological Macromolecules, 2021, v. 183, p. 2131-2141-
dc.identifier.issn0141-8130-
dc.identifier.urihttp://hdl.handle.net/10722/301248-
dc.descriptionHybrid open access-
dc.description.abstractEnamel regeneration currently -is limited by our inability to duplicate artificially its complicated and well-aligned hydroxyapatite structure. The initial formation of enamel occurs in enamel organs where the ameloblasts secret enamel extracellular matrix formed a unique gel-like microenvironment. The enamel extracellular matrix is mainly composed by amelogenin and non-amelogenin. In this study, an innovative strategy was proposed to regenerate enamel-like tissue by constructing a microenvironment using biomimetic enamel matrix proteins (biomimetic EMPs) composed of modified leucine-rich amelogenin peptide (mLRAP) and non-amelogenin analog (NAA). Impressively, the regenerated enamel in this biomimetic EMPs on etched enamel surface produced prismatic structures, and showed similar mechanical properties to natural enamel. The results of X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) showed that regenerated crystal was hydroxyapatite. Molecular dynamics simulation analysis showed the binding energy between mLRAP and NAA were electrostatic forces and Van der Walls. These results introduced a promising strategy to induce crystal growth of enamel-like hydroxyapatite for biomimetic reproduction of materials with complicated hierarchical microstructures.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijbiomac-
dc.relation.ispartofInternational Journal of Biological Macromolecules-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBiomimetic regeneration-
dc.subjectEnamel-
dc.subjectExtracellular matrix proteins-
dc.titleEnamel-like tissue regeneration by using biomimetic enamel matrix proteins-
dc.typeArticle-
dc.identifier.emailWong, HM: wonghmg@hkucc.hku.hk-
dc.identifier.authorityWong, HM=rp00042-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ijbiomac.2021.06.028-
dc.identifier.pmid34111481-
dc.identifier.scopuseid_2-s2.0-85107556420-
dc.identifier.hkuros323578-
dc.identifier.volume183-
dc.identifier.spage2131-
dc.identifier.epage2141-
dc.identifier.isiWOS:000674935000007-
dc.publisher.placeNetherlands-

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