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Article: The global, regional, and national burden of cancer among adolescents and young adults in 204 countries and territories, 1990–2019: a population-based study

TitleThe global, regional, and national burden of cancer among adolescents and young adults in 204 countries and territories, 1990–2019: a population-based study
Authors
KeywordsAdolescents and young adults
Global burden of disease study
Cancer
Prevalence
Mortality
Issue Date2021
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org
Citation
Journal of Hematology & Oncology, 2021, v. 14 n. 1, p. article no. 89 How to Cite?
AbstractBackground: Accurate appraisal of burden of adolescents and young adults (AYAs) cancers is crucial to informing resource allocation and policy making. We report on the latest estimates of burden of AYA cancers in 204 countries and territories between 1990 and 2019 in association with socio-demographic index (SDI). Patients and methods: Estimates from the Global Burden of Disease study 2019 were used to analyse incidence, mortality, and disability-adjusted life years (DALYs) due to AYA cancers at global, regional, and national levels by sex. Association between AYA cancer burden and SDI were investigated. Burdens of AYA cancers were contextualized in comparison with childhood and older adult cancers. All estimates are reported as counts and age-standardized rates per 100,000 person-years. Results: In 2019, there were 1.2 million incident cases, 0.4 million deaths, and 23.5 million DALYs due to AYA cancers globally. The highest age-standardized incidence rate occurred in Western Europe (75.3 [Females] and 67.4 [Males] per 100,000 person-years). Age-standardized death (23.2 [Females] and 13.9 [Males] per 100,000 person-years) and DALY (1328.3 [Females] and 1059.2 [Males] per 100,000 person-years) rates were highest in Oceania. Increasing SDI was associated with a higher age-standardized incidence rate. An inverted U-shaped association was identified between SDI and death and DALY rates. AYA cancers collectively is the second leading cause of non-communicable diseases-related deaths globally in 2019. DALYs of AYA cancers ranked the second globally and the first in low and low-middle SDI locations when compared with that of childhood and older adult cancers. Conclusion: The global burden of AYA cancers is substantial and disproportionally affect populations in limited-resource settings. Capacity building for AYA cancers is essential in promoting equity and population health worldwide.
Persistent Identifierhttp://hdl.handle.net/10722/301246
ISSN
2018 Impact Factor: 8.731
2020 SCImago Journal Rankings: 4.305
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorWen, YF-
dc.contributor.authorChen, MX-
dc.contributor.authorYin, G-
dc.contributor.authorLin, R-
dc.contributor.authorZhong, YJ-
dc.contributor.authorDong, QQ-
dc.contributor.authorWong, HM-
dc.date.accessioned2021-07-27T08:08:17Z-
dc.date.available2021-07-27T08:08:17Z-
dc.date.issued2021-
dc.identifier.citationJournal of Hematology & Oncology, 2021, v. 14 n. 1, p. article no. 89-
dc.identifier.issn1756-8722-
dc.identifier.urihttp://hdl.handle.net/10722/301246-
dc.description.abstractBackground: Accurate appraisal of burden of adolescents and young adults (AYAs) cancers is crucial to informing resource allocation and policy making. We report on the latest estimates of burden of AYA cancers in 204 countries and territories between 1990 and 2019 in association with socio-demographic index (SDI). Patients and methods: Estimates from the Global Burden of Disease study 2019 were used to analyse incidence, mortality, and disability-adjusted life years (DALYs) due to AYA cancers at global, regional, and national levels by sex. Association between AYA cancer burden and SDI were investigated. Burdens of AYA cancers were contextualized in comparison with childhood and older adult cancers. All estimates are reported as counts and age-standardized rates per 100,000 person-years. Results: In 2019, there were 1.2 million incident cases, 0.4 million deaths, and 23.5 million DALYs due to AYA cancers globally. The highest age-standardized incidence rate occurred in Western Europe (75.3 [Females] and 67.4 [Males] per 100,000 person-years). Age-standardized death (23.2 [Females] and 13.9 [Males] per 100,000 person-years) and DALY (1328.3 [Females] and 1059.2 [Males] per 100,000 person-years) rates were highest in Oceania. Increasing SDI was associated with a higher age-standardized incidence rate. An inverted U-shaped association was identified between SDI and death and DALY rates. AYA cancers collectively is the second leading cause of non-communicable diseases-related deaths globally in 2019. DALYs of AYA cancers ranked the second globally and the first in low and low-middle SDI locations when compared with that of childhood and older adult cancers. Conclusion: The global burden of AYA cancers is substantial and disproportionally affect populations in limited-resource settings. Capacity building for AYA cancers is essential in promoting equity and population health worldwide.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jhoonline.org-
dc.relation.ispartofJournal of Hematology & Oncology-
dc.rightsJournal of Hematology & Oncology. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdolescents and young adults-
dc.subjectGlobal burden of disease study-
dc.subjectCancer-
dc.subjectPrevalence-
dc.subjectMortality-
dc.titleThe global, regional, and national burden of cancer among adolescents and young adults in 204 countries and territories, 1990–2019: a population-based study-
dc.typeArticle-
dc.identifier.emailWong, HM: wonghmg@hkucc.hku.hk-
dc.identifier.authorityWong, HM=rp00042-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s13045-021-01093-3-
dc.identifier.pmid34108026-
dc.identifier.pmcidPMC8191013-
dc.identifier.scopuseid_2-s2.0-85107406527-
dc.identifier.hkuros323574-
dc.identifier.volume14-
dc.identifier.issue1-
dc.identifier.spagearticle no. 89-
dc.identifier.epagearticle no. 89-
dc.publisher.placeUnited Kingdom-

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