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Article: Research progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases

TitleResearch progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases
Authors
KeywordsPhosphatidylinositol 4-kinase
PI4K inhibitors
Cancer
Virus replication
Inflammation
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal of Pharmacology, 2021, v. 907, article no. 174300 How to Cite?
AbstractPhosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate phosphatidylinositol 4-phosphate (PI4P). Studies on biological functions reveal that PI4K is closely related to the occurrence and development of various inflammatory diseases such as obesity, cancer, viral infections, malaria, Alzheimer's disease, etc. PI4K-related inhibitors have been found to have the effects of inhibiting virus replication, anti-cancer, treating malaria and reducing rejection in organ transplants, among which MMV390048, an anti-malaria drug, has entered phase II clinical trial. This review discusses the classification, structure, distribution and related inhibitors of PI4K and their role in the progression of cancer, viral replication, and other inflammation induced diseases to explore their potential as therapeutic targets.
Persistent Identifierhttp://hdl.handle.net/10722/301238
ISSN
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.055
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, YP-
dc.contributor.authorMikrani, R-
dc.contributor.authorHu, YF-
dc.contributor.authorBaig, MMFA-
dc.contributor.authorAbbas, M-
dc.contributor.authorAkhtar, F-
dc.contributor.authorXu, M-
dc.date.accessioned2021-07-27T08:08:09Z-
dc.date.available2021-07-27T08:08:09Z-
dc.date.issued2021-
dc.identifier.citationEuropean Journal of Pharmacology, 2021, v. 907, article no. 174300-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://hdl.handle.net/10722/301238-
dc.description.abstractPhosphatidylinositol 4-kinase (PI4K) is a lipid kinase that can catalyze the transfer of phosphate group from ATP to the inositol ring of phosphatidylinositol (PtdIns) resulting in the phosphorylation of PtdIns at 4-OH sites, to generate phosphatidylinositol 4-phosphate (PI4P). Studies on biological functions reveal that PI4K is closely related to the occurrence and development of various inflammatory diseases such as obesity, cancer, viral infections, malaria, Alzheimer's disease, etc. PI4K-related inhibitors have been found to have the effects of inhibiting virus replication, anti-cancer, treating malaria and reducing rejection in organ transplants, among which MMV390048, an anti-malaria drug, has entered phase II clinical trial. This review discusses the classification, structure, distribution and related inhibitors of PI4K and their role in the progression of cancer, viral replication, and other inflammation induced diseases to explore their potential as therapeutic targets.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar-
dc.relation.ispartofEuropean Journal of Pharmacology-
dc.subjectPhosphatidylinositol 4-kinase-
dc.subjectPI4K inhibitors-
dc.subjectCancer-
dc.subjectVirus replication-
dc.subjectInflammation-
dc.titleResearch progress of phosphatidylinositol 4-kinase and its inhibitors in inflammatory diseases-
dc.typeArticle-
dc.identifier.emailBaig, MMFA: faran@hku.hk-
dc.identifier.authorityBaig, MMFA=rp02755-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2021.174300-
dc.identifier.pmid34217706-
dc.identifier.scopuseid_2-s2.0-85109168843-
dc.identifier.hkuros323349-
dc.identifier.volume907-
dc.identifier.spagearticle no. 174300-
dc.identifier.epagearticle no. 174300-
dc.identifier.isiWOS:000683037500005-
dc.publisher.placeNetherlands-

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