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Article: Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination

TitleSustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination
Authors
Issue Date2021
PublisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
Citation
PLoS Pathogens, 2021, v. 17 n. 6, p. article no. e1009647 How to Cite?
AbstractHIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8+ T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon viral infection. Here, we investigated a program death-1 (PD1)-based vaccine by fusion of simian immunodeficiency virus capsid antigen to soluble PD1. Homologous vaccinations suppressed setpoint viremia to undetectable levels in vaccinated macaques following a high-dose intravenous challenge by the pathogenic SHIVSF162P3CN. Poly-functional effector-memory CD8+ T cells were not only induced after vaccination, but were also recalled upon viral challenge for viremia control as determined by CD8 depletion. Vaccine-induced effector memory CD8+ subsets displayed high cytotoxicity-related genes by single-cell analysis. Vaccinees with sustained viremia suppression for over two years responded to boost vaccination without viral rebound. These results demonstrated that PD1-based vaccine-induced effector-memory CD8+ T cells were recalled by AIDS virus infection, providing a potential immunotherapy for functional cure.
Persistent Identifierhttp://hdl.handle.net/10722/301159
ISSN
2023 Impact Factor: 5.5
2023 SCImago Journal Rankings: 2.223
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, YC-
dc.contributor.authorLIU, W-
dc.contributor.authorYim, LY-
dc.contributor.authorLi, X-
dc.contributor.authorWANG, H-
dc.contributor.authorYUE, M-
dc.contributor.authorNIU, M-
dc.contributor.authorCHENG, L-
dc.contributor.authorLING, L-
dc.contributor.authorDU, Y-
dc.contributor.authorCHEN, SMY-
dc.contributor.authorCheung, KW-
dc.contributor.authorWANG, H-
dc.contributor.authorTANG, X-
dc.contributor.authorTANG, J-
dc.contributor.authorZHANG, H-
dc.contributor.authorSong, Y-
dc.contributor.authorChakrabarti, LA-
dc.contributor.authorChen, Z-
dc.date.accessioned2021-07-27T08:07:00Z-
dc.date.available2021-07-27T08:07:00Z-
dc.date.issued2021-
dc.identifier.citationPLoS Pathogens, 2021, v. 17 n. 6, p. article no. e1009647-
dc.identifier.issn1553-7366-
dc.identifier.urihttp://hdl.handle.net/10722/301159-
dc.description.abstractHIV-1 functional cure requires sustained viral suppression without antiretroviral therapy. While effector-memory CD8+ T lymphocytes are essential for viremia control, few vaccines elicit such cellular immunity that could be potently recalled upon viral infection. Here, we investigated a program death-1 (PD1)-based vaccine by fusion of simian immunodeficiency virus capsid antigen to soluble PD1. Homologous vaccinations suppressed setpoint viremia to undetectable levels in vaccinated macaques following a high-dose intravenous challenge by the pathogenic SHIVSF162P3CN. Poly-functional effector-memory CD8+ T cells were not only induced after vaccination, but were also recalled upon viral challenge for viremia control as determined by CD8 depletion. Vaccine-induced effector memory CD8+ subsets displayed high cytotoxicity-related genes by single-cell analysis. Vaccinees with sustained viremia suppression for over two years responded to boost vaccination without viral rebound. These results demonstrated that PD1-based vaccine-induced effector-memory CD8+ T cells were recalled by AIDS virus infection, providing a potential immunotherapy for functional cure.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374-
dc.relation.ispartofPLoS Pathogens-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination-
dc.typeArticle-
dc.identifier.emailYim, LY: ayim@hku.hk-
dc.identifier.emailSong, Y: songy@hku.hk-
dc.identifier.emailChen, Z: zchenai@hku.hk-
dc.identifier.authoritySong, Y=rp00488-
dc.identifier.authorityChen, Z=rp00243-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.ppat.1009647-
dc.identifier.pmid34125864-
dc.identifier.pmcidPMC8202916-
dc.identifier.scopuseid_2-s2.0-85108223468-
dc.identifier.hkuros323372-
dc.identifier.volume17-
dc.identifier.issue6-
dc.identifier.spagearticle no. e1009647-
dc.identifier.epagearticle no. e1009647-
dc.identifier.isiWOS:000664723300003-
dc.publisher.placeUnited States-

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