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Article: Regulation of Melatonin and Neurotransmission in Alzheimer's Disease
Title | Regulation of Melatonin and Neurotransmission in Alzheimer's Disease |
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Authors | |
Keywords | melatonin neurotransmission Alzheimer’s disease |
Issue Date | 2021 |
Publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms |
Citation | International Journal of Molecular Sciences, 2021, v. 22 n. 13, p. article no. 6841 How to Cite? |
Abstract | Alzheimer’s disease is a neurodegenerative disorder associated with age, and is characterized by pathological markers such as amyloid-beta plaques and neurofibrillary tangles. Symptoms of AD include cognitive impairments, anxiety and depression. It has also been shown that individuals with AD have impaired neurotransmission, which may result from the accumulation of amyloid plaques and neurofibrillary tangles. Preclinical studies showed that melatonin, a monoaminergic neurotransmitter released from the pineal gland, is able to ameliorate AD pathologies and restore cognitive impairments. Theoretically, inhibition of the pathological progression of AD by melatonin treatment should also restore the impaired neurotransmission. This review aims to explore the impact of AD on neurotransmission, and whether and how melatonin can enhance neurotransmission via improving AD pathology. |
Persistent Identifier | http://hdl.handle.net/10722/300875 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | ROY, J | - |
dc.contributor.author | TSUI, KC | - |
dc.contributor.author | Ng, J | - |
dc.contributor.author | Fung, ML | - |
dc.contributor.author | Lim, LW | - |
dc.date.accessioned | 2021-07-06T03:11:24Z | - |
dc.date.available | 2021-07-06T03:11:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2021, v. 22 n. 13, p. article no. 6841 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300875 | - |
dc.description.abstract | Alzheimer’s disease is a neurodegenerative disorder associated with age, and is characterized by pathological markers such as amyloid-beta plaques and neurofibrillary tangles. Symptoms of AD include cognitive impairments, anxiety and depression. It has also been shown that individuals with AD have impaired neurotransmission, which may result from the accumulation of amyloid plaques and neurofibrillary tangles. Preclinical studies showed that melatonin, a monoaminergic neurotransmitter released from the pineal gland, is able to ameliorate AD pathologies and restore cognitive impairments. Theoretically, inhibition of the pathological progression of AD by melatonin treatment should also restore the impaired neurotransmission. This review aims to explore the impact of AD on neurotransmission, and whether and how melatonin can enhance neurotransmission via improving AD pathology. | - |
dc.language | eng | - |
dc.publisher | Molecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | melatonin | - |
dc.subject | neurotransmission | - |
dc.subject | Alzheimer’s disease | - |
dc.title | Regulation of Melatonin and Neurotransmission in Alzheimer's Disease | - |
dc.type | Article | - |
dc.identifier.email | Fung, ML: fungml@hku.hk | - |
dc.identifier.email | Lim, LW: limlw@hku.hk | - |
dc.identifier.authority | Fung, ML=rp00433 | - |
dc.identifier.authority | Lim, LW=rp02088 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/ijms22136841 | - |
dc.identifier.pmid | 34202125 | - |
dc.identifier.pmcid | PMC8268832 | - |
dc.identifier.scopus | eid_2-s2.0-85108421866 | - |
dc.identifier.hkuros | 323221 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | article no. 6841 | - |
dc.identifier.epage | article no. 6841 | - |
dc.identifier.isi | WOS:000671067600001 | - |
dc.publisher.place | Switzerland | - |