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Article: TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases

TitleTGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases
Authors
Keywordsneurogenesis
TGF-β
smad
depression
stress
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells
Citation
Cells, 2021, v. 10 n. 6, p. article no. 1382 How to Cite?
AbstractTGF-β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF-β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF-β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.
Persistent Identifierhttp://hdl.handle.net/10722/300856
ISSN
2017 Impact Factor: 4.829
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorHIEW, LF-
dc.contributor.authorPOON, CH-
dc.contributor.authorYou, HZ-
dc.contributor.authorLim, LW-
dc.date.accessioned2021-07-06T03:11:10Z-
dc.date.available2021-07-06T03:11:10Z-
dc.date.issued2021-
dc.identifier.citationCells, 2021, v. 10 n. 6, p. article no. 1382-
dc.identifier.issn2073-4409-
dc.identifier.urihttp://hdl.handle.net/10722/300856-
dc.description.abstractTGF-β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF-β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF-β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells-
dc.relation.ispartofCells-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectneurogenesis-
dc.subjectTGF-β-
dc.subjectsmad-
dc.subjectdepression-
dc.subjectstress-
dc.titleTGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cells10061382-
dc.identifier.pmid34205102-
dc.identifier.pmcidPMC8226492-
dc.identifier.scopuseid_2-s2.0-85110407783-
dc.identifier.hkuros323223-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spagearticle no. 1382-
dc.identifier.epagearticle no. 1382-
dc.publisher.placeSwitzerland-

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