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Conference Paper: Statin use reduces incident hip fractures among older Chinese people with type 2 diabetes, independent of mean haemoglobin A1c and duration of diabetes
Title | Statin use reduces incident hip fractures among older Chinese people with type 2 diabetes, independent of mean haemoglobin A1c and duration of diabetes |
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Authors | |
Issue Date | 2020 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ |
Citation | 25th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2020. In Hong Kong Medical Journal, 2020, v. 26 n. 1, Suppl. 1, p. 41, abstract no. 69 How to Cite? |
Abstract | Introduction: Statins are associated with reduced risks of hip fractures in the general population. People with type 2 diabetes have increased fracture risk related to its unique bone pathophysiology and level of glycaemia. We therefore studied the effect of statins on incident hip fractures in people with type 2 diabetes.
Methods: Chinese individuals with type 2 diabetes aged ≥60 years were identified from electronic health records in Hong Kong between 2008 and 2012 and observed for incident hip fractures. Participants were categorised into ‘never users’, ‘long-term users’, and ‘new users’ of statin. Cumulative defined daily doses (cDDD) of statins were calculated. Multivariable Cox regression analysis was used to calculate the adjusted hazard ratio (aHR) of incident hip fractures with the use of statins.
Results: Among the 60 825 participants, both ‘long-term users’ and ‘new users’ of statin had less incident hip fractures compared with ‘never users’ (aHR=0.57 and 0.60 respectively, both P<0.001). Comparison between ‘never users’ and ‘new users’ with propensity score matching for baseline characteristics revealed a comparable reduction in incident hip fractures among ‘new users’ (aHR=0.50, P<0.001). A dose-response relationship was observed, with more risk reduction in the quartiles with higher cDDD of statins (aHR=0.49 for Q2, aHR=0.37 for Q3, aHR=0.23 for Q4; all P<0.001 compared with ‘never users’). These protective effects were independent of haemoglobin A1c and the duration of diabetes.
Conclusion: Statin use reduces incident hip fractures among older Chinese people with type 2 diabetes, in a dose-response manner. |
Persistent Identifier | http://hdl.handle.net/10722/300821 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Lui, TWD | - |
dc.contributor.author | Lee, CH | - |
dc.contributor.author | Chow, WS | - |
dc.contributor.author | Fong, CHY | - |
dc.contributor.author | Siu, DCW | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Lam, KSL | - |
dc.date.accessioned | 2021-07-06T03:10:42Z | - |
dc.date.available | 2021-07-06T03:10:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | 25th Medical Research Conference, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2020. In Hong Kong Medical Journal, 2020, v. 26 n. 1, Suppl. 1, p. 41, abstract no. 69 | - |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300821 | - |
dc.description.abstract | Introduction: Statins are associated with reduced risks of hip fractures in the general population. People with type 2 diabetes have increased fracture risk related to its unique bone pathophysiology and level of glycaemia. We therefore studied the effect of statins on incident hip fractures in people with type 2 diabetes. Methods: Chinese individuals with type 2 diabetes aged ≥60 years were identified from electronic health records in Hong Kong between 2008 and 2012 and observed for incident hip fractures. Participants were categorised into ‘never users’, ‘long-term users’, and ‘new users’ of statin. Cumulative defined daily doses (cDDD) of statins were calculated. Multivariable Cox regression analysis was used to calculate the adjusted hazard ratio (aHR) of incident hip fractures with the use of statins. Results: Among the 60 825 participants, both ‘long-term users’ and ‘new users’ of statin had less incident hip fractures compared with ‘never users’ (aHR=0.57 and 0.60 respectively, both P<0.001). Comparison between ‘never users’ and ‘new users’ with propensity score matching for baseline characteristics revealed a comparable reduction in incident hip fractures among ‘new users’ (aHR=0.50, P<0.001). A dose-response relationship was observed, with more risk reduction in the quartiles with higher cDDD of statins (aHR=0.49 for Q2, aHR=0.37 for Q3, aHR=0.23 for Q4; all P<0.001 compared with ‘never users’). These protective effects were independent of haemoglobin A1c and the duration of diabetes. Conclusion: Statin use reduces incident hip fractures among older Chinese people with type 2 diabetes, in a dose-response manner. | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ | - |
dc.relation.ispartof | Hong Kong Medical Journal | - |
dc.relation.ispartof | 25th Medical Research Conference, 2020 | - |
dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.title | Statin use reduces incident hip fractures among older Chinese people with type 2 diabetes, independent of mean haemoglobin A1c and duration of diabetes | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lui, TWD: dtwlui@hku.hk | - |
dc.identifier.email | Siu, DCW: cwdsiu@hkucc.hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Lam, KSL: ksllam@hku.hk | - |
dc.identifier.authority | Lui, TWD=rp02803 | - |
dc.identifier.authority | Siu, DCW=rp00534 | - |
dc.identifier.authority | Lam, KSL=rp00343 | - |
dc.description.nature | abstract | - |
dc.identifier.hkuros | 323151 | - |
dc.identifier.volume | 26 | - |
dc.identifier.issue | 1, Suppl. 1 | - |
dc.identifier.spage | 41, abstract no. 69 | - |
dc.identifier.epage | 41, abstract no. 69 | - |
dc.publisher.place | Hong Kong | - |