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Article: Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

TitleSingle-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 3684 How to Cite?
AbstractInteraction between tumor cells and immune cells in the tumor microenvironment is important in cancer development. Immune cells interact with the tumor cells to shape this process. Here, we use single-cell RNA sequencing analysis to delineate the immune landscape and tumor heterogeneity in a cohort of patients with HBV-associated human hepatocellular carcinoma (HCC). We found that tumor-associated macrophages suppress tumor T cell infiltration and TIGIT-NECTIN2 interaction regulates the immunosuppressive environment. The cell state transition of immune cells towards a more immunosuppressive and exhaustive status exemplifies the overall cancer-promoting immunocellular landscape. Furthermore, the heterogeneity of global molecular profiles reveals co-existence of intra-tumoral and inter-tumoral heterogeneity, but is more apparent in the latter. This analysis of the immunosuppressive landscape and intercellular interactions provides mechanistic information for the design of efficacious immune-oncology treatments in hepatocellular carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/300810
ISSN
2020 Impact Factor: 14.919
2015 SCImago Journal Rankings: 6.539

 

DC FieldValueLanguage
dc.contributor.authorHo, DWH-
dc.contributor.authorTsui, YM-
dc.contributor.authorChan, LK-
dc.contributor.authorSze, KMF-
dc.contributor.authorZhang, X-
dc.contributor.authorCHEU, JWS-
dc.contributor.authorChiu, YT-
dc.contributor.authorLee, JMF-
dc.contributor.authorChan, ACY-
dc.contributor.authorCheung, ETY-
dc.contributor.authorYau, DTW-
dc.contributor.authorChia, NH-
dc.contributor.authorLo, ILO-
dc.contributor.authorSham, PC-
dc.contributor.authorCheung, TT-
dc.contributor.authorWong, CCL-
dc.contributor.authorNg, IOL-
dc.date.accessioned2021-07-06T03:10:34Z-
dc.date.available2021-07-06T03:10:34Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 3684-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/300810-
dc.description.abstractInteraction between tumor cells and immune cells in the tumor microenvironment is important in cancer development. Immune cells interact with the tumor cells to shape this process. Here, we use single-cell RNA sequencing analysis to delineate the immune landscape and tumor heterogeneity in a cohort of patients with HBV-associated human hepatocellular carcinoma (HCC). We found that tumor-associated macrophages suppress tumor T cell infiltration and TIGIT-NECTIN2 interaction regulates the immunosuppressive environment. The cell state transition of immune cells towards a more immunosuppressive and exhaustive status exemplifies the overall cancer-promoting immunocellular landscape. Furthermore, the heterogeneity of global molecular profiles reveals co-existence of intra-tumoral and inter-tumoral heterogeneity, but is more apparent in the latter. This analysis of the immunosuppressive landscape and intercellular interactions provides mechanistic information for the design of efficacious immune-oncology treatments in hepatocellular carcinoma.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSingle-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma-
dc.typeArticle-
dc.identifier.emailHo, DWH: dwhho@hku.hk-
dc.identifier.emailTsui, YM: ymtsui@hku.hk-
dc.identifier.emailSze, KMF: karensze@hkucc.hku.hk-
dc.identifier.emailZhang, X: vanilla6@hku.hk-
dc.identifier.emailChiu, YT: ellechiu@pathology.hku.hk-
dc.identifier.emailLee, JMF: joyce@pathology.hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailWong, CCL: carmencl@pathology.hku.hk-
dc.identifier.emailNg, IOL: iolng@hku.hk-
dc.identifier.authorityHo, DWH=rp02285-
dc.identifier.authorityChan, LK=rp02289-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authoritySham, PC=rp00459-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityWong, CCL=rp01602-
dc.identifier.authorityNg, IOL=rp00335-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-24010-1-
dc.identifier.scopuseid_2-s2.0-85108073271-
dc.identifier.hkuros323210-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 3684-
dc.identifier.epagearticle no. 3684-
dc.publisher.placeUnited Kingdom-

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