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Conference Paper: Performance of Proxy-reported EQ-5D Youth Version 5-level (EQ-5D-Y-5L) in Comparison with Three-level (EQ-5D-Y-3L) in Chinese Patients with Adolescent Idiopathic Scoliosis

TitlePerformance of Proxy-reported EQ-5D Youth Version 5-level (EQ-5D-Y-5L) in Comparison with Three-level (EQ-5D-Y-3L) in Chinese Patients with Adolescent Idiopathic Scoliosis
Authors
Issue Date2021
PublisherElsevier Inc. The Journal's web site is located at http://www.valueinhealthjournal.com/
Citation
Virtual ISPOR (International Society for Pharmacoeconomics and Outcomes Research) Conference 2021: HEOR: Evolving for Tomorrow's Challenges, 17-20 May 2021. In Value in Health, 2021, v. 24 n. Suppl. 1, p. S105, abstract no. PIH38 How to Cite?
AbstractOBJECTIVES: Adolescent idiopathic scoliosis (AIS) has significant influence on patients' health-related quality of life (HRQoL). Three-level and five-level EQ-5D-Y (hereafter named Y-3L and Y-5L) are validated utility instruments to assess HRQoL but psychometric properties of the proxy versions remain unknown. This study aims to assess the performance of the proxy-reported Y-5L compared with Y-3L for assessing AIS patients. METHODS: 129 AIS patient-proxy dyads were recruited from a hospital in Hong Kong, China. Patients' caregivers were asked to complete proxy-reported Y-3L and Y-5L. All participants' sociodemographic and patients' clinical characteristics were collected. We assessed redistribution property and ceiling effects from Y-3L to Y-5L. Subgroup analysis was also conducted, where chi-squared test was used to detect differences in proportion of reporting problems. Ability of 'full health' defined by Y-3L and Y-5L to predict clinical outcomes was examined using area under curve (AUC). RESULTS: Mean age of patients was 13.3±1.4 years, 90.7% were female. Proxies were mostly mothers (71.1%) and only 28.6% received tertiary education or above. Consistencies between Y-3L and Y-5L responses were high for all dimensions (93.8-99.2%). All dimensions showed high ceiling effect (Y-3L:77.5-97.7%; Y-5L:77.5-96.9%) while largest reduction was observed in 'Doing usual activities' (absolute reduction: 2.3%; relative reduction: 2.5%) and 'Feeling worried/sad/unhappy' (absolute reduction: 2.3%; relative reduction: 2.9%). In 'Doing usual activities' dimension, less patients treated with bracing reported full-health status compared to those under observation in Y-3L (P-value: 0.08) and Y-5L (P-value: 0.034), proxies with secondary school or below education and those as mothers (P-value: 0.04 and 0.036 respectively) were more likely to report problems. In AUS analysis, 'full health' defined by Y-3L and Y-5L was not found to predict clinical outcomes. CONCLUSIONS: The overall performance of proxy-reported Y-3L and Y-5L in AIS patients was appeared to be similar. However, Y-5L is potentially more discriminative among mothers and proxies with lower education levels.
DescriptionPoster Presentatin - no. PIH38
Persistent Identifierhttp://hdl.handle.net/10722/300720
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.507

 

DC FieldValueLanguage
dc.contributor.authorLin, J-
dc.contributor.authorWong, CKH-
dc.contributor.authorCheung, JPY-
dc.contributor.authorCheung, WHP-
dc.contributor.authorLuo, N-
dc.date.accessioned2021-06-18T14:56:06Z-
dc.date.available2021-06-18T14:56:06Z-
dc.date.issued2021-
dc.identifier.citationVirtual ISPOR (International Society for Pharmacoeconomics and Outcomes Research) Conference 2021: HEOR: Evolving for Tomorrow's Challenges, 17-20 May 2021. In Value in Health, 2021, v. 24 n. Suppl. 1, p. S105, abstract no. PIH38-
dc.identifier.issn1098-3015-
dc.identifier.urihttp://hdl.handle.net/10722/300720-
dc.descriptionPoster Presentatin - no. PIH38-
dc.description.abstractOBJECTIVES: Adolescent idiopathic scoliosis (AIS) has significant influence on patients' health-related quality of life (HRQoL). Three-level and five-level EQ-5D-Y (hereafter named Y-3L and Y-5L) are validated utility instruments to assess HRQoL but psychometric properties of the proxy versions remain unknown. This study aims to assess the performance of the proxy-reported Y-5L compared with Y-3L for assessing AIS patients. METHODS: 129 AIS patient-proxy dyads were recruited from a hospital in Hong Kong, China. Patients' caregivers were asked to complete proxy-reported Y-3L and Y-5L. All participants' sociodemographic and patients' clinical characteristics were collected. We assessed redistribution property and ceiling effects from Y-3L to Y-5L. Subgroup analysis was also conducted, where chi-squared test was used to detect differences in proportion of reporting problems. Ability of 'full health' defined by Y-3L and Y-5L to predict clinical outcomes was examined using area under curve (AUC). RESULTS: Mean age of patients was 13.3±1.4 years, 90.7% were female. Proxies were mostly mothers (71.1%) and only 28.6% received tertiary education or above. Consistencies between Y-3L and Y-5L responses were high for all dimensions (93.8-99.2%). All dimensions showed high ceiling effect (Y-3L:77.5-97.7%; Y-5L:77.5-96.9%) while largest reduction was observed in 'Doing usual activities' (absolute reduction: 2.3%; relative reduction: 2.5%) and 'Feeling worried/sad/unhappy' (absolute reduction: 2.3%; relative reduction: 2.9%). In 'Doing usual activities' dimension, less patients treated with bracing reported full-health status compared to those under observation in Y-3L (P-value: 0.08) and Y-5L (P-value: 0.034), proxies with secondary school or below education and those as mothers (P-value: 0.04 and 0.036 respectively) were more likely to report problems. In AUS analysis, 'full health' defined by Y-3L and Y-5L was not found to predict clinical outcomes. CONCLUSIONS: The overall performance of proxy-reported Y-3L and Y-5L in AIS patients was appeared to be similar. However, Y-5L is potentially more discriminative among mothers and proxies with lower education levels.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.valueinhealthjournal.com/-
dc.relation.ispartofValue in Health-
dc.relation.ispartofVirtual ISPOR (International Society for Pharmacoeconomics and Outcomes Research) Conference 2021-
dc.titlePerformance of Proxy-reported EQ-5D Youth Version 5-level (EQ-5D-Y-5L) in Comparison with Three-level (EQ-5D-Y-3L) in Chinese Patients with Adolescent Idiopathic Scoliosis-
dc.typeConference_Paper-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailCheung, JPY: cheungjp@hku.hk-
dc.identifier.emailCheung, WHP: gnuehcp6@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityCheung, JPY=rp01685-
dc.description.natureabstract-
dc.identifier.doi10.1016/j.jval.2021.04.556-
dc.identifier.hkuros322831-
dc.identifier.hkuros322953-
dc.identifier.volume24-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS105, abstract no. PIH38-
dc.identifier.epageS105, abstract no. PIH38-
dc.publisher.placeUnited States-

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