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Article: Sex hormones Related Ocular dryness in Breast Cancer Women
Title | Sex hormones Related Ocular dryness in Breast Cancer Women |
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Authors | |
Keywords | dry eye syndrome breast cancer sex hormones ocular surface equilibrium |
Issue Date | 2021 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm |
Citation | Journal of Clinical Medicine, 2021, v. 10 n. 12, p. article no. 2620 How to Cite? |
Abstract | Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Methods: A literature review regarding the role of sex hormone changes and systemic hormonal replacement treatments (SHRT) in DES available on PubMed and Web of Science was made without any restriction of language. Results: Androgens exert their role on the ocular surface supporting meibomian gland function and exerting a pro-sebaceous effect. Estrogen seems to show a pro/inflammatory role on the ocular surface, while SHRT effects on dry eye are still not well defined, determining apparently contradictory consequences on the ocular surface homeostasis. The role of sex hormones on dry eye pathogenesis is most likely the result of a strict crosstalk between the protective androgens effects and the androgen-modulating effects of estrogens on the meibomian glands. Conclusions: Patients with a pathological or iatrogenic hormonal imbalance, such as in the case of breast cancer, should be assessed for dry eye disease, as well as systemic dryness, in order to restore their social and personal quality of life. View Full-Text
Keywords: dry eye syndrome; breast cancer; sex hormones; ocular surface equilibrium |
Persistent Identifier | http://hdl.handle.net/10722/300534 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.882 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Grasso, A | - |
dc.contributor.author | Di Zazzo, A | - |
dc.contributor.author | Giannaccare, G | - |
dc.contributor.author | Sung, J | - |
dc.contributor.author | Inomata, T | - |
dc.contributor.author | Shih, KC | - |
dc.contributor.author | Micera, A | - |
dc.contributor.author | Guadenzi, D | - |
dc.contributor.author | Spelta, S | - |
dc.contributor.author | Romeo, MA | - |
dc.contributor.author | Orsaria, P | - |
dc.contributor.author | Coassin, M | - |
dc.contributor.author | Altomare, V | - |
dc.date.accessioned | 2021-06-18T14:53:21Z | - |
dc.date.available | 2021-06-18T14:53:21Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Clinical Medicine, 2021, v. 10 n. 12, p. article no. 2620 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300534 | - |
dc.description.abstract | Background: Dry eye syndrome (DES) is strictly connected to systemic and topical sex hormones. Breast cancer treatment, the subsequent hormonal therapy, the subsequent hyperandrogenism and the early sudden menopause, may be responsible for ocular surface system failure and its clinical manifestation as dry eye disease. This local dryness is part of the breast cancer iatrogenic dryness, which affects overall mucosal tissue in the fragile population of those with breast cancer. Methods: A literature review regarding the role of sex hormone changes and systemic hormonal replacement treatments (SHRT) in DES available on PubMed and Web of Science was made without any restriction of language. Results: Androgens exert their role on the ocular surface supporting meibomian gland function and exerting a pro-sebaceous effect. Estrogen seems to show a pro/inflammatory role on the ocular surface, while SHRT effects on dry eye are still not well defined, determining apparently contradictory consequences on the ocular surface homeostasis. The role of sex hormones on dry eye pathogenesis is most likely the result of a strict crosstalk between the protective androgens effects and the androgen-modulating effects of estrogens on the meibomian glands. Conclusions: Patients with a pathological or iatrogenic hormonal imbalance, such as in the case of breast cancer, should be assessed for dry eye disease, as well as systemic dryness, in order to restore their social and personal quality of life. View Full-Text Keywords: dry eye syndrome; breast cancer; sex hormones; ocular surface equilibrium | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm | - |
dc.relation.ispartof | Journal of Clinical Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | dry eye syndrome | - |
dc.subject | breast cancer | - |
dc.subject | sex hormones | - |
dc.subject | ocular surface equilibrium | - |
dc.title | Sex hormones Related Ocular dryness in Breast Cancer Women | - |
dc.type | Article | - |
dc.identifier.email | Shih, KC: kcshih@hku.hk | - |
dc.identifier.authority | Shih, KC=rp01374 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/jcm10122620 | - |
dc.identifier.pmid | 34198684 | - |
dc.identifier.pmcid | PMC8232194 | - |
dc.identifier.scopus | eid_2-s2.0-85114074840 | - |
dc.identifier.hkuros | 322836 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | article no. 2620 | - |
dc.identifier.epage | article no. 2620 | - |
dc.identifier.isi | WOS:000666301500001 | - |
dc.publisher.place | Switzerland | - |