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Conference Paper: New Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization
Title | New Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization |
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Authors | |
Issue Date | 2020 |
Citation | AsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference, Kyoto, Japan, 24 - 26 February, 2020 How to Cite? |
Abstract | Over the past decade at the University of Hong Kong, our laboratory has developed several innovative methods for synthetic biologics, including Serine/Threonine Ligation (STL) for protein chemical synthesis, P-B desulfurization for chemoselective peptide desulfurization, OPA bioconjugation for protein modification and OPA chemoselective peptide cyclization. These methods have been successfully applied for synthesis of proteins with post-translational modifications, preparation of antibodydrug conjugates, and antibacterial cyclic peptides, including daptomycin and teixobactin. |
Description | Peptide Track: Constrained and Cyclic Peptides: Synthesis and Manufacturing |
Persistent Identifier | http://hdl.handle.net/10722/300381 |
DC Field | Value | Language |
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dc.contributor.author | Li, XC | - |
dc.date.accessioned | 2021-06-08T04:43:48Z | - |
dc.date.available | 2021-06-08T04:43:48Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | AsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference, Kyoto, Japan, 24 - 26 February, 2020 | - |
dc.identifier.uri | http://hdl.handle.net/10722/300381 | - |
dc.description | Peptide Track: Constrained and Cyclic Peptides: Synthesis and Manufacturing | - |
dc.description.abstract | Over the past decade at the University of Hong Kong, our laboratory has developed several innovative methods for synthetic biologics, including Serine/Threonine Ligation (STL) for protein chemical synthesis, P-B desulfurization for chemoselective peptide desulfurization, OPA bioconjugation for protein modification and OPA chemoselective peptide cyclization. These methods have been successfully applied for synthesis of proteins with post-translational modifications, preparation of antibodydrug conjugates, and antibacterial cyclic peptides, including daptomycin and teixobactin. | - |
dc.language | eng | - |
dc.relation.ispartof | AsiaTIDES: Oligonucleotide & Peptide Therapeutics Conference | - |
dc.title | New Methods and Strategies for Protein Chemical Synthesis/Modification and Peptide Cyclization | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Li, XC: xuechenl@hku.hk | - |
dc.identifier.authority | Li, XC=rp00742 | - |
dc.identifier.hkuros | 311903 | - |