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Article: The applicability of the ACOSOG Z0011 criteria to breast cancer patients in Hong Kong

TitleThe applicability of the ACOSOG Z0011 criteria to breast cancer patients in Hong Kong
Authors
KeywordsBreast cancer
Biopsy
Lymph node dissection
Sentinel lymph node (SLN)
Issue Date2021
PublisherAME Publishing Company. The Journal's web site is located at http://cco.amegroups.com/index
Citation
Chinese Clinical Oncology, 2021, June, v.10 n. 3, article no. 27 How to Cite?
AbstractBackground: The ACOSOG Z0011 trial demonstrated safe omission of axillary lymph node dissection (ALND) in patients with one or two positive sentinel lymph nodes (SLNs) receiving breast conservative surgery, followed by whole breast irradiation and adjuvant systemic treatment. This study aims to evaluate the exportability of the ACOSOG Z0011 criteria in an Asian/Chinese cohort residing in Hong Kong. Methods: Retrospective analysis of a prospectively maintained database in a University affiliated tertiary breast centre was performed from June 2014 to May 2019. All breast cancer patients with no palpable adenopathy before surgery, one or more positive sentinel lymph nodes on histological examination and no prior neoadjuvant systemic treatment were recruited. Patients were grouped as eligible or ineligible according to the ACOSOG Z0011 criteria. The eligible group was compared with the sentinel alone group in the ACOSOG Z0011 cohort. Results: Two hundred and forty-eight patients were recruited into the study. Sixty patients (24%) met the ACOSOG Z0011 criteria and could potentially avoid ALND. A higher percentage of clinical T2 tumors were observed in our eligible group than in the ACOSOG Z0011 trial (P=0.002). The histological subtype, tumor grade, estrogen receptor (ER)/progestogen receptor (PR) status and lymphovascular invasion status did not differ. There was no statistically significant difference in the proportion of SLN micrometastasis and macrometastasis between the two groups. Conclusions: This study demonstrated clinical similarities between our eligible cohort and the ACOSOG Z0011 cohort, which confirms exportability of the ACOSOG Z0011 criteria to a subset of population in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/300272
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.690
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMan, CMV-
dc.contributor.authorLo, MS-
dc.contributor.authorKwong, A-
dc.date.accessioned2021-06-04T08:40:35Z-
dc.date.available2021-06-04T08:40:35Z-
dc.date.issued2021-
dc.identifier.citationChinese Clinical Oncology, 2021, June, v.10 n. 3, article no. 27-
dc.identifier.issn2304-3865-
dc.identifier.urihttp://hdl.handle.net/10722/300272-
dc.description.abstractBackground: The ACOSOG Z0011 trial demonstrated safe omission of axillary lymph node dissection (ALND) in patients with one or two positive sentinel lymph nodes (SLNs) receiving breast conservative surgery, followed by whole breast irradiation and adjuvant systemic treatment. This study aims to evaluate the exportability of the ACOSOG Z0011 criteria in an Asian/Chinese cohort residing in Hong Kong. Methods: Retrospective analysis of a prospectively maintained database in a University affiliated tertiary breast centre was performed from June 2014 to May 2019. All breast cancer patients with no palpable adenopathy before surgery, one or more positive sentinel lymph nodes on histological examination and no prior neoadjuvant systemic treatment were recruited. Patients were grouped as eligible or ineligible according to the ACOSOG Z0011 criteria. The eligible group was compared with the sentinel alone group in the ACOSOG Z0011 cohort. Results: Two hundred and forty-eight patients were recruited into the study. Sixty patients (24%) met the ACOSOG Z0011 criteria and could potentially avoid ALND. A higher percentage of clinical T2 tumors were observed in our eligible group than in the ACOSOG Z0011 trial (P=0.002). The histological subtype, tumor grade, estrogen receptor (ER)/progestogen receptor (PR) status and lymphovascular invasion status did not differ. There was no statistically significant difference in the proportion of SLN micrometastasis and macrometastasis between the two groups. Conclusions: This study demonstrated clinical similarities between our eligible cohort and the ACOSOG Z0011 cohort, which confirms exportability of the ACOSOG Z0011 criteria to a subset of population in Hong Kong.-
dc.languageeng-
dc.publisherAME Publishing Company. The Journal's web site is located at http://cco.amegroups.com/index-
dc.relation.ispartofChinese Clinical Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBreast cancer-
dc.subjectBiopsy-
dc.subjectLymph node dissection-
dc.subjectSentinel lymph node (SLN)-
dc.titleThe applicability of the ACOSOG Z0011 criteria to breast cancer patients in Hong Kong-
dc.typeArticle-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.21037/cco-20-239-
dc.identifier.scopuseid_2-s2.0-85107675474-
dc.identifier.hkuros322711-
dc.identifier.volume10-
dc.identifier.issue3-
dc.identifier.spagearticle no. 27-
dc.identifier.epagearticle no. 27-
dc.identifier.isiWOS:000754541900010-
dc.publisher.placeHong Kong-

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