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Article: Sex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis

TitleSex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis
Authors
Keywordsclinical high-risk
gender differences
negative symptoms
psychosis
sex differences
Issue Date2021
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893
Citation
Early Intervention in Psychiatry, 2021, Epub 2021-02-16 How to Cite?
AbstractAim: Sex differences are well documented in schizophrenia, but have been much less studied in at-risk mental state (ARMS) for psychosis. We aimed to examine sex differences in symptomatology, cognition, social and role functioning in individuals with ARMS, with specific focus on clarifying relationships between sex, negative symptoms and functioning. Methods: One hundred and seventy-seven Chinese participants aged 15–40 years with ARMS were recruited from a specialized early intervention service in Hong Kong. ARMS status was verified by Comprehensive Assessment of At-Risk Mental State. Assessments encompassing symptom profiles, a brief battery of cognitive tests and social and role functioning were conducted. Brief Negative Symptom Scale was adapted to measure negative symptoms at the level of five core domains. Results: Males with ARMS exhibited significantly poorer social functioning and more severe asociality of negative symptoms than female counterparts. Mediation analysis revealed that sex difference in social functioning became statistically insignificant when asocality was included in the model, indicating that asociality mediated the relationship between sex and social functioning. No sex differences were observed in other core domains of negative symptoms, other symptom dimensions, cognitive measures and role functioning. Conclusions: This study suggests that sex differences in ARMS may be less pronounced that those observed in established psychotic disorders. Our findings of differential pattern of asociality between sexes and its mediating role on sex difference in social functioning underscore the importance in investigating negative symptoms at a separable domain-level. Further research is required to identify sex-specific predictors of longitudinal outcomes in at-risk populations. © 2021 John Wiley & Sons Australia, Ltd
Persistent Identifierhttp://hdl.handle.net/10722/299781
ISSN
2020 Impact Factor: 2.732
2015 SCImago Journal Rankings: 1.071
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KN-
dc.contributor.authorChang, WC-
dc.contributor.authorNg, CM-
dc.contributor.authorLee, HC-
dc.contributor.authorChan, SI-
dc.contributor.authorChiu, SY-
dc.contributor.authorWong, CF-
dc.contributor.authorWo, SF-
dc.contributor.authorLee, HM-
dc.contributor.authorChan, KW-
dc.contributor.authorWong, MC-
dc.contributor.authorChan, KL-
dc.contributor.authorYeung, WS-
dc.contributor.authorChan, CWH-
dc.contributor.authorChoy, LW-
dc.contributor.authorChong, SY-
dc.contributor.authorSiu, MW-
dc.contributor.authorLo, TL-
dc.contributor.authorYan, WC-
dc.contributor.authorNg, MK-
dc.contributor.authorPoon, LT-
dc.contributor.authorPang, PF-
dc.contributor.authorLam, WC-
dc.contributor.authorWong, YC-
dc.contributor.authorChung, WS-
dc.contributor.authorMo, YM-
dc.contributor.authorLui, SY-
dc.contributor.authorHui, LM-
dc.contributor.authorChen, EYH-
dc.date.accessioned2021-05-26T03:28:58Z-
dc.date.available2021-05-26T03:28:58Z-
dc.date.issued2021-
dc.identifier.citationEarly Intervention in Psychiatry, 2021, Epub 2021-02-16-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/299781-
dc.description.abstractAim: Sex differences are well documented in schizophrenia, but have been much less studied in at-risk mental state (ARMS) for psychosis. We aimed to examine sex differences in symptomatology, cognition, social and role functioning in individuals with ARMS, with specific focus on clarifying relationships between sex, negative symptoms and functioning. Methods: One hundred and seventy-seven Chinese participants aged 15–40 years with ARMS were recruited from a specialized early intervention service in Hong Kong. ARMS status was verified by Comprehensive Assessment of At-Risk Mental State. Assessments encompassing symptom profiles, a brief battery of cognitive tests and social and role functioning were conducted. Brief Negative Symptom Scale was adapted to measure negative symptoms at the level of five core domains. Results: Males with ARMS exhibited significantly poorer social functioning and more severe asociality of negative symptoms than female counterparts. Mediation analysis revealed that sex difference in social functioning became statistically insignificant when asocality was included in the model, indicating that asociality mediated the relationship between sex and social functioning. No sex differences were observed in other core domains of negative symptoms, other symptom dimensions, cognitive measures and role functioning. Conclusions: This study suggests that sex differences in ARMS may be less pronounced that those observed in established psychotic disorders. Our findings of differential pattern of asociality between sexes and its mediating role on sex difference in social functioning underscore the importance in investigating negative symptoms at a separable domain-level. Further research is required to identify sex-specific predictors of longitudinal outcomes in at-risk populations. © 2021 John Wiley & Sons Australia, Ltd-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectclinical high-risk-
dc.subjectgender differences-
dc.subjectnegative symptoms-
dc.subjectpsychosis-
dc.subjectsex differences-
dc.titleSex differences in symptom severity, cognition and psychosocial functioning among individuals with at‐risk mental state for psychosis-
dc.typeArticle-
dc.identifier.emailChang, WC: changwc@hku.hk-
dc.identifier.emailNg, CM: maryncm@hku.hk-
dc.identifier.emailLee, HM: edwinlhm@hku.hk-
dc.identifier.emailChan, KW: kwsherry@hku.hk-
dc.identifier.emailYeung, WS: yeunws@hku.hk-
dc.identifier.emailNg, MK: rmkng@hkucc.hku.hk-
dc.identifier.emailLui, SY: lsy570@hku.hk-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChang, WC=rp01465-
dc.identifier.authorityLee, HM=rp01575-
dc.identifier.authorityChan, KW=rp00539-
dc.identifier.authorityLui, SY=rp02747-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/eip.13131-
dc.identifier.pmid33590717-
dc.identifier.scopuseid_2-s2.0-85101440817-
dc.identifier.hkuros322493-
dc.identifier.volumeEpub 2021-02-16-
dc.identifier.isiWOS:000618185800001-
dc.publisher.placeUnited States-

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