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Article: Association between systolic blood pressure and diabetic retinopathy in both hypertensive and normotensive patients with type 2 diabetes: Risk factors and healthcare implications

TitleAssociation between systolic blood pressure and diabetic retinopathy in both hypertensive and normotensive patients with type 2 diabetes: Risk factors and healthcare implications
Authors
Keywordssystolic blood pressure
diabetic retinopathy
association
type 2 diabetes management
risk factor
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/healthcare
Citation
Healthcare, 2021, v. 9 n. 5, p. article no. 580 How to Cite?
AbstractA common diabetes-related microvascular complication is diabetic retinopathy (DR), yet associations between blood pressure (BP) and risks for DR in diabetic patients with normal BP received inadequate attention. This may lead to ‘clinical inertia’ in early DR prevention. We aimed to assess whether the extent to which systolic BP levels were associated with DR in patients with type 2 diabetes (T2DM) and normal BP were similar to that in those with concurrent hypertension. Data were collected from patients with T2DM attending ophthalmic check-up with primary care referral (n = 2510). BP measurements, clinical laboratory tests, and dilated fundus examination were conducted according to gold standard of diagnosis and routine clinical procedure. Of all subjects, over 40% were normotensive and one fifth were clinically diagnosed with DR. Systolic BP levels increased across DR categories of escalated severity irrespective of the coexistence of hypertension. Ordinal logistic regression analysis showed that an increased systolic BP was independently and significantly associated with DR (adjusted odds ratio [aOR] = 1.020, p < 0.001 for hypertensives; aOR = 1.019, p = 0.018 for normotensives), after adjusting for diabetes duration, sex, lifestyles, and haemoglobin A1c levels. Regular monitoring of systolic BP should not be neglected in routine diabetes management even when BP falls within the normal range. (200 words)
Persistent Identifierhttp://hdl.handle.net/10722/299704
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.606
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, YT-
dc.contributor.authorWang, Y-
dc.contributor.authorHu, XJ-
dc.contributor.authorChen, JH-
dc.contributor.authorLi, YY-
dc.contributor.authorZhong, QY-
dc.contributor.authorCheng, H-
dc.contributor.authorMohammed, BH-
dc.contributor.authorLiang, XL-
dc.contributor.authorHernandez, J-
dc.contributor.authorHuang, WY-
dc.contributor.authorWang, HHX-
dc.date.accessioned2021-05-26T03:27:53Z-
dc.date.available2021-05-26T03:27:53Z-
dc.date.issued2021-
dc.identifier.citationHealthcare, 2021, v. 9 n. 5, p. article no. 580-
dc.identifier.issn2227-9032-
dc.identifier.urihttp://hdl.handle.net/10722/299704-
dc.description.abstractA common diabetes-related microvascular complication is diabetic retinopathy (DR), yet associations between blood pressure (BP) and risks for DR in diabetic patients with normal BP received inadequate attention. This may lead to ‘clinical inertia’ in early DR prevention. We aimed to assess whether the extent to which systolic BP levels were associated with DR in patients with type 2 diabetes (T2DM) and normal BP were similar to that in those with concurrent hypertension. Data were collected from patients with T2DM attending ophthalmic check-up with primary care referral (n = 2510). BP measurements, clinical laboratory tests, and dilated fundus examination were conducted according to gold standard of diagnosis and routine clinical procedure. Of all subjects, over 40% were normotensive and one fifth were clinically diagnosed with DR. Systolic BP levels increased across DR categories of escalated severity irrespective of the coexistence of hypertension. Ordinal logistic regression analysis showed that an increased systolic BP was independently and significantly associated with DR (adjusted odds ratio [aOR] = 1.020, p < 0.001 for hypertensives; aOR = 1.019, p = 0.018 for normotensives), after adjusting for diabetes duration, sex, lifestyles, and haemoglobin A1c levels. Regular monitoring of systolic BP should not be neglected in routine diabetes management even when BP falls within the normal range. (200 words)-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/healthcare-
dc.relation.ispartofHealthcare-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectsystolic blood pressure-
dc.subjectdiabetic retinopathy-
dc.subjectassociation-
dc.subjecttype 2 diabetes management-
dc.subjectrisk factor-
dc.titleAssociation between systolic blood pressure and diabetic retinopathy in both hypertensive and normotensive patients with type 2 diabetes: Risk factors and healthcare implications-
dc.typeArticle-
dc.identifier.emailMohammed, BH: bedru@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/healthcare9050580-
dc.identifier.pmid34068355-
dc.identifier.pmcidPMC8153301-
dc.identifier.scopuseid_2-s2.0-85106756387-
dc.identifier.hkuros322574-
dc.identifier.volume9-
dc.identifier.issue5-
dc.identifier.spagearticle no. 580-
dc.identifier.epagearticle no. 580-
dc.identifier.isiWOS:000654311100001-
dc.publisher.placeSwitzerland-

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