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Article: Phenotypic and functional characteristics of a novel influenza virus hemagglutinin-specific memory NK cell

TitlePhenotypic and functional characteristics of a novel influenza virus hemagglutinin-specific memory NK cell
Authors
KeywordsCytotoxicity
Gamma IFN
Glycosylation
Hemagglutinin
Immune memory
Issue Date2021
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2021, v. 95 n. 12, p. article no. e00165 How to Cite?
AbstractImmune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain inconclusive. In this study, we identified a novel mouse spleen NK cell subset expressing NKp46 and NKG2A induced by intranasal influenza virus infection. These memory NK cells specifically recognize N-linked glycosylation sites on influenza hemagglutinin (HA) protein. Different from memory-like NK cells reported previously, these NKp46+ NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of gamma interferon (IFN-γ) response against influenza virus-infected cells, which could be reversed by pifithrin-μ, a p53-heat shock protein 70 (HSP70) signaling inhibitor. During recall responses, splenic NKp46+ NKG2A+ NK cells were recruited to infected lung and modulated viral clearance of virus and CD8+ T cell distribution, resulting in improved clinical outcomes. This long-lived NK memory bridges innate and adaptive immune memory response and promotes the homeostasis of local environment during recall response. IMPORTANCE In this study, we demonstrate a novel hemagglutinin (HA)-specific NKp46+ NKG2A+ NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased gamma interferon (IFN-γ) on reencountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.
Persistent Identifierhttp://hdl.handle.net/10722/299703
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.378
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZheng, J-
dc.contributor.authorWen, L-
dc.contributor.authorYen, HL-
dc.contributor.authorLiu, M-
dc.contributor.authorLiu, Y-
dc.contributor.authorTeng, O-
dc.contributor.authorWu, WF-
dc.contributor.authorNI, K-
dc.contributor.authorLam, KT-
dc.contributor.authorHUANG, C-
dc.contributor.authorYANG, J-
dc.contributor.authorLau, YL-
dc.contributor.authorPerlman, S-
dc.contributor.authorPeiris, M-
dc.contributor.authorTu, W-
dc.date.accessioned2021-05-26T03:27:52Z-
dc.date.available2021-05-26T03:27:52Z-
dc.date.issued2021-
dc.identifier.citationJournal of Virology, 2021, v. 95 n. 12, p. article no. e00165-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/299703-
dc.description.abstractImmune memory represents the most efficient defense against invasion and transmission of infectious pathogens. In contrast to memory T and B cells, the roles of innate immunity in recall responses remain inconclusive. In this study, we identified a novel mouse spleen NK cell subset expressing NKp46 and NKG2A induced by intranasal influenza virus infection. These memory NK cells specifically recognize N-linked glycosylation sites on influenza hemagglutinin (HA) protein. Different from memory-like NK cells reported previously, these NKp46+ NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of gamma interferon (IFN-γ) response against influenza virus-infected cells, which could be reversed by pifithrin-μ, a p53-heat shock protein 70 (HSP70) signaling inhibitor. During recall responses, splenic NKp46+ NKG2A+ NK cells were recruited to infected lung and modulated viral clearance of virus and CD8+ T cell distribution, resulting in improved clinical outcomes. This long-lived NK memory bridges innate and adaptive immune memory response and promotes the homeostasis of local environment during recall response. IMPORTANCE In this study, we demonstrate a novel hemagglutinin (HA)-specific NKp46+ NKG2A+ NK cell subset induced by influenza A virus infection. These memory NK cells show virus-specific decreased cytotoxicity and increased gamma interferon (IFN-γ) on reencountering the same influenza virus antigen. In addition, they modulate host recall responses and CD8 T cell distribution, thus bridging the innate immune and adaptive immune responses during influenza virus infection.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/-
dc.relation.ispartofJournal of Virology-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subjectCytotoxicity-
dc.subjectGamma IFN-
dc.subjectGlycosylation-
dc.subjectHemagglutinin-
dc.subjectImmune memory-
dc.titlePhenotypic and functional characteristics of a novel influenza virus hemagglutinin-specific memory NK cell-
dc.typeArticle-
dc.identifier.emailYen, HL: hyen@hku.hk-
dc.identifier.emailLiu, Y: yinpingl@hku.hk-
dc.identifier.emailLam, KT: tailam@hkucc.hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.emailTu, W: wwtu@hku.hk-
dc.identifier.authorityYen, HL=rp00304-
dc.identifier.authorityLiu, Y=rp00269-
dc.identifier.authorityLau, YL=rp00361-
dc.identifier.authorityPeiris, M=rp00410-
dc.identifier.authorityTu, W=rp00416-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1128/JVI.00165-21-
dc.identifier.pmid33827945-
dc.identifier.scopuseid_2-s2.0-85106470256-
dc.identifier.hkuros322514-
dc.identifier.volume95-
dc.identifier.issue12-
dc.identifier.spagearticle no. e00165-
dc.identifier.epagearticle no. e00165-
dc.identifier.isiWOS:000656996900006-
dc.publisher.placeUnited States-

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