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Article: Changes in circumpapillary retinal vessel density after acute primary angle closure episode via OCT angiography

TitleChanges in circumpapillary retinal vessel density after acute primary angle closure episode via OCT angiography
Authors
KeywordsAcute primary angle closure
Circumpapillary vessel density
Optical coherence tomography angiography
Issue Date2021
PublisherSpringer Netherlands. The Journal's web site is located at https://www.springer.com/journal/10792
Citation
International Ophthalmology, 2021, v. 41, p. 2389-2397 How to Cite?
AbstractPurpose: To investigate the changes and evaluate the diagnosis value of circumpapillary vessel density (VD) in cases of acute primary angle closure (APAC). Design: Case–control study. Methods: APAC patients with a history of unilateral acute attack were enrolled. The eyes with acute episode constituted the case group while the contralateral eyes without attack consisted of the control group. Ophthalmic examinations including slit-lamp examination, best-corrected visual acuity, intraocular pressure and visual field were carried out. Retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC) were measured by spectral-domain optical coherence tomography, while VD was assessed by optical coherence tomography angiography. Results: The whole en face image vessel density (wiVD), circumpapillary vessel density (cpVD) and inside disk VD for both all vessels and capillary were all significantly lower in the APAC eyes compared to the fellow eyes (P < 0.01 for all). In APAC eyes, the wiVD, inside disk VD and cpVD both for all vessels and capillary were all positively correlated with RNFL and GCC thicknesses but negatively correlated with the mean deviation (MD), pattern standard deviation (PSD) and the duration of acute attack (all P < 0.01). From the ROC curve, the cpVDcap, wiVDcap, cpVDall and wiVDall all showed comparable diagnostic ability with RNFL, GCC and MD to differentiate eyes with APAC from the fellow eyes (all P > 0.05). The inside disk VDcap and VDall demonstrated significant lower diagnostic ability than the cpVDcap, wiVDcap, cpVDall and wiVDall (all P < 0.001). Conclusions: In APAC eyes, circumpapillary VD decreased significantly compared with the fellow unaffected eyes. They were significantly correlated with thicknesses of RNFL and GCC, and visual field MD and PSD in the APAC eyes. The patients with longer duration of acute attack were more likely to have lower cpVD. For APAC, the diagnostic ability of wiVD and cpVD was similar with RNFL, GCC and MD and was higher than inside disk VD.
Persistent Identifierhttp://hdl.handle.net/10722/299687
ISSN
2023 Impact Factor: 1.4
2023 SCImago Journal Rankings: 0.709
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNie, L-
dc.contributor.authorXu, J-
dc.contributor.authorFu, L-
dc.contributor.authorYe, Y-
dc.contributor.authorChan, YK-
dc.contributor.authorLi, T-
dc.contributor.authorPan, W-
dc.contributor.authorLu, P-
dc.date.accessioned2021-05-26T03:27:39Z-
dc.date.available2021-05-26T03:27:39Z-
dc.date.issued2021-
dc.identifier.citationInternational Ophthalmology, 2021, v. 41, p. 2389-2397-
dc.identifier.issn0165-5701-
dc.identifier.urihttp://hdl.handle.net/10722/299687-
dc.description.abstractPurpose: To investigate the changes and evaluate the diagnosis value of circumpapillary vessel density (VD) in cases of acute primary angle closure (APAC). Design: Case–control study. Methods: APAC patients with a history of unilateral acute attack were enrolled. The eyes with acute episode constituted the case group while the contralateral eyes without attack consisted of the control group. Ophthalmic examinations including slit-lamp examination, best-corrected visual acuity, intraocular pressure and visual field were carried out. Retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC) were measured by spectral-domain optical coherence tomography, while VD was assessed by optical coherence tomography angiography. Results: The whole en face image vessel density (wiVD), circumpapillary vessel density (cpVD) and inside disk VD for both all vessels and capillary were all significantly lower in the APAC eyes compared to the fellow eyes (P < 0.01 for all). In APAC eyes, the wiVD, inside disk VD and cpVD both for all vessels and capillary were all positively correlated with RNFL and GCC thicknesses but negatively correlated with the mean deviation (MD), pattern standard deviation (PSD) and the duration of acute attack (all P < 0.01). From the ROC curve, the cpVDcap, wiVDcap, cpVDall and wiVDall all showed comparable diagnostic ability with RNFL, GCC and MD to differentiate eyes with APAC from the fellow eyes (all P > 0.05). The inside disk VDcap and VDall demonstrated significant lower diagnostic ability than the cpVDcap, wiVDcap, cpVDall and wiVDall (all P < 0.001). Conclusions: In APAC eyes, circumpapillary VD decreased significantly compared with the fellow unaffected eyes. They were significantly correlated with thicknesses of RNFL and GCC, and visual field MD and PSD in the APAC eyes. The patients with longer duration of acute attack were more likely to have lower cpVD. For APAC, the diagnostic ability of wiVD and cpVD was similar with RNFL, GCC and MD and was higher than inside disk VD.-
dc.languageeng-
dc.publisherSpringer Netherlands. The Journal's web site is located at https://www.springer.com/journal/10792-
dc.relation.ispartofInternational Ophthalmology-
dc.rightsAccepted Manuscript (AAM) This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectAcute primary angle closure-
dc.subjectCircumpapillary vessel density-
dc.subjectOptical coherence tomography angiography-
dc.titleChanges in circumpapillary retinal vessel density after acute primary angle closure episode via OCT angiography-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10792-021-01793-2-
dc.identifier.pmid33948808-
dc.identifier.scopuseid_2-s2.0-85105479158-
dc.identifier.hkuros322475-
dc.identifier.volume41-
dc.identifier.spage2389-
dc.identifier.epage2397-
dc.identifier.isiWOS:000647017600001-
dc.publisher.placeNetherlands-

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