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Article: Decreased use of broad-spectrum antibiotics during COVID-19 epidemic in South Korea

TitleDecreased use of broad-spectrum antibiotics during COVID-19 epidemic in South Korea
Authors
KeywordsAntibiotic
COVID-19
respiratory virus
Korea
stewardship
Issue Date2021
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
The Journal of Infectious Diseases, 2021, Epub 2021-04-15 How to Cite?
AbstractBackground: Early in the COVID-19 pandemic, there was a concern over possible increase in antibiotic use due to co-infections among COVID-19 patients in the community. Here, we evaluate the changes in nationwide use of broad-spectrum antibiotics during the COVID-19 epidemic in South Korea. Methods: We obtained national reimbursement data on the prescription of antibiotics, including penicillin with beta-lactamase inhibitors, cephalosporins, fluoroquinolones, and macrolides. We examined the number of antibiotic prescriptions compared with the previous three years in the same period from August to July. To quantify the impact of the COVID-19 epidemic on antibiotic use, we developed a regression model adjusting for changes of viral acute respiratory tract infections (ARTIs) which are an important factor driving antibiotic use. Results: During the COVID-19 epidemic in South Korea, the broad-spectrum antibiotic use dropped by 15%–55% compared to the previous 3 years. Overall reduction in antibiotic use adjusting for ARTIs was estimated to be 14%–30%, with a larger impact in children. Conclusions: Our study found that broad-spectrum antibiotic use was substantially reduced during the COVID-19 epidemic in South Korea. This reduction can be in part due to reduced ARTIs as a result of stringent public health interventions including social distancing measures.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/299342
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 2.387

 

DC FieldValueLanguage
dc.contributor.authorRyu, S-
dc.contributor.authorHwang, Y-
dc.contributor.authorAli, ST-
dc.contributor.authorKim, DS-
dc.contributor.authorKlein, EY-
dc.contributor.authorLau, EHY-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2021-05-10T07:00:26Z-
dc.date.available2021-05-10T07:00:26Z-
dc.date.issued2021-
dc.identifier.citationThe Journal of Infectious Diseases, 2021, Epub 2021-04-15-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/299342-
dc.descriptionHybrid open access-
dc.description.abstractBackground: Early in the COVID-19 pandemic, there was a concern over possible increase in antibiotic use due to co-infections among COVID-19 patients in the community. Here, we evaluate the changes in nationwide use of broad-spectrum antibiotics during the COVID-19 epidemic in South Korea. Methods: We obtained national reimbursement data on the prescription of antibiotics, including penicillin with beta-lactamase inhibitors, cephalosporins, fluoroquinolones, and macrolides. We examined the number of antibiotic prescriptions compared with the previous three years in the same period from August to July. To quantify the impact of the COVID-19 epidemic on antibiotic use, we developed a regression model adjusting for changes of viral acute respiratory tract infections (ARTIs) which are an important factor driving antibiotic use. Results: During the COVID-19 epidemic in South Korea, the broad-spectrum antibiotic use dropped by 15%–55% compared to the previous 3 years. Overall reduction in antibiotic use adjusting for ARTIs was estimated to be 14%–30%, with a larger impact in children. Conclusions: Our study found that broad-spectrum antibiotic use was substantially reduced during the COVID-19 epidemic in South Korea. This reduction can be in part due to reduced ARTIs as a result of stringent public health interventions including social distancing measures.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org-
dc.relation.ispartofThe Journal of Infectious Diseases-
dc.rightsPost-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [The Journal of Infectious Diseases] following peer review. The definitive publisher-authenticated version [The Journal of Infectious Diseases, 2021, Epub 2021-04-15] is available online at: [http://dx.doi.org/10.1093/infdis/jiab208].-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntibiotic-
dc.subjectCOVID-19-
dc.subjectrespiratory virus-
dc.subjectKorea-
dc.subjectstewardship-
dc.titleDecreased use of broad-spectrum antibiotics during COVID-19 epidemic in South Korea-
dc.typeArticle-
dc.identifier.emailAli, ST: alist15@hku.hk-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityAli, ST=rp02673-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepostprint-
dc.identifier.doi10.1093/infdis/jiab208-
dc.identifier.scopuseid_2-s2.0-85106350475-
dc.identifier.hkuros322388-
dc.identifier.volumeEpub 2021-04-15-
dc.publisher.placeUnited States-

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