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Article: Low dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor

TitleLow dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2021, v. 11 n. 1, p. article no. 7403 How to Cite?
AbstractColon cancer is one of the leading causes of cancer death worldwide. It is widely believed that environmental factors contribute to colon cancer development. Zearalenone (ZEA) is non-steroidal estrogenic mycotoxin that is widely found in the human diet and animal feeds. Most cancer studies of ZEA focused on estrogen sensitive cancers, while few focused on other types, such as colon cancer; despite the gastrointestinal tract being the first barrier exposed to food contaminants. This study investigated the stimulatory effects of ZEA on colon cancer cell lines and their underlying molecular mechanisms. ZEA promoted anchorage independent cell growth and cell cycle progression through promoting G1-to-S phase transition. Proliferative marker, cyclin D1 and Ki67 were found to be upregulated upon ZEA treatment. G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER. The growth promoting effect mediated through GPER were suppressed by its antagonist G15. ZEA were found to promote the downstream parallel pathway, MAPK signaling pathway and Hippo pathway effector YAP1. Altogether, our observations suggest a novel mechanism by which ZEA could promote cancer growth and provide a new perspective on the carcinogenicity of ZEA.
Persistent Identifierhttp://hdl.handle.net/10722/299332
ISSN
2020 Impact Factor: 4.379
2020 SCImago Journal Rankings: 1.240
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorL, EKK-
dc.contributor.authorLee, JCY-
dc.contributor.authorTurner, PC-
dc.contributor.authorEl-Nezamy, H-
dc.date.accessioned2021-05-10T07:00:17Z-
dc.date.available2021-05-10T07:00:17Z-
dc.date.issued2021-
dc.identifier.citationScientific Reports, 2021, v. 11 n. 1, p. article no. 7403-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/299332-
dc.description.abstractColon cancer is one of the leading causes of cancer death worldwide. It is widely believed that environmental factors contribute to colon cancer development. Zearalenone (ZEA) is non-steroidal estrogenic mycotoxin that is widely found in the human diet and animal feeds. Most cancer studies of ZEA focused on estrogen sensitive cancers, while few focused on other types, such as colon cancer; despite the gastrointestinal tract being the first barrier exposed to food contaminants. This study investigated the stimulatory effects of ZEA on colon cancer cell lines and their underlying molecular mechanisms. ZEA promoted anchorage independent cell growth and cell cycle progression through promoting G1-to-S phase transition. Proliferative marker, cyclin D1 and Ki67 were found to be upregulated upon ZEA treatment. G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER. The growth promoting effect mediated through GPER were suppressed by its antagonist G15. ZEA were found to promote the downstream parallel pathway, MAPK signaling pathway and Hippo pathway effector YAP1. Altogether, our observations suggest a novel mechanism by which ZEA could promote cancer growth and provide a new perspective on the carcinogenicity of ZEA.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsScientific Reports. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleLow dose of zearalenone elevated colon cancer cell growth through G protein-coupled estrogenic receptor-
dc.typeArticle-
dc.identifier.emailLee, JCY: jettylee@hku.hk-
dc.identifier.emailEl-Nezamy, H: elnezami@hkucc.hku.hk-
dc.identifier.authorityLee, JCY=rp01511-
dc.identifier.authorityEl-Nezamy, H=rp00694-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-021-86788-w-
dc.identifier.pmid33795755-
dc.identifier.pmcidPMC8016995-
dc.identifier.scopuseid_2-s2.0-85103632039-
dc.identifier.hkuros322381-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spagearticle no. 7403-
dc.identifier.epagearticle no. 7403-
dc.identifier.isiWOS:000636797900033-
dc.publisher.placeUnited Kingdom-

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