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Article: Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection

TitleHost-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12, p. article no. 1914 How to Cite?
AbstractInnate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ T cells to produce interleukin 17 A (IL-17A) for early protection against H1N1 influenza infection. During infection, the lung γδ T cell pool is constantly supplemented by thymic output, with recent emigrants infiltrating into the lung parenchyma and airway to acquire tissue-resident feature. Single-cell studies identify IL-17A-producing γδ T (Tγδ17) cells with a phenotype of TCRγδhiCD3hiAQP3hiCXCR6hi in both infected mice and patients with pneumonia. Mechanistically, host cell-released lipids during viral infection are presented by lung infiltrating CD1d+ B-1a cells to activate IL-17A production in γδ T cells via γδTCR-mediated IRF4-dependent transcription. Reduced IL-17A production in γδ T cells is detected in mice either lacking B-1a cells or with ablated CD1d in B cells. Our findings identify a local host-immune crosstalk and define important cellular and molecular mediators for early innate defense against lung viral infection.
Persistent Identifierhttp://hdl.handle.net/10722/299153
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, X-
dc.contributor.authorLin, X-
dc.contributor.authorZheng, Z-
dc.contributor.authorLu, B-
dc.contributor.authorWang, J-
dc.contributor.authorTan, AHM-
dc.contributor.authorZhao, M-
dc.contributor.authorLoh, JT-
dc.contributor.authorNg, SW-
dc.contributor.authorChen, Q-
dc.contributor.authorXiao, F-
dc.contributor.authorHuang, E-
dc.contributor.authorKo, KH-
dc.contributor.authorHuang, Z-
dc.contributor.authorLi, J-
dc.contributor.authorKok, KH-
dc.contributor.authorLu, G-
dc.contributor.authorLiu, X-
dc.contributor.authorLam, KP-
dc.contributor.authorLiu, W-
dc.contributor.authorZhang, Y-
dc.contributor.authorMak, TW-
dc.contributor.authorLu, L-
dc.date.accessioned2021-04-28T02:26:53Z-
dc.date.available2021-04-28T02:26:53Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12, p. article no. 1914-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/299153-
dc.description.abstractInnate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung γδ T cells to produce interleukin 17 A (IL-17A) for early protection against H1N1 influenza infection. During infection, the lung γδ T cell pool is constantly supplemented by thymic output, with recent emigrants infiltrating into the lung parenchyma and airway to acquire tissue-resident feature. Single-cell studies identify IL-17A-producing γδ T (Tγδ17) cells with a phenotype of TCRγδhiCD3hiAQP3hiCXCR6hi in both infected mice and patients with pneumonia. Mechanistically, host cell-released lipids during viral infection are presented by lung infiltrating CD1d+ B-1a cells to activate IL-17A production in γδ T cells via γδTCR-mediated IRF4-dependent transcription. Reduced IL-17A production in γδ T cells is detected in mice either lacking B-1a cells or with ablated CD1d in B cells. Our findings identify a local host-immune crosstalk and define important cellular and molecular mediators for early innate defense against lung viral infection.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleHost-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection-
dc.typeArticle-
dc.identifier.emailWang, X: xiaohuiwang@hku.hk-
dc.identifier.emailLin, X: linxiang@hku.hk-
dc.identifier.emailXiao, F: xiaof@hku.hk-
dc.identifier.emailHuang, E: heyhk49@hku.hk-
dc.identifier.emailKo, KH: khko@hku.hk-
dc.identifier.emailKok, KH: khkok@hku.hk-
dc.identifier.emailMak, TW: takwmak@hku.hk-
dc.identifier.emailLu, L: liweilu@hku.hk-
dc.identifier.authorityWang, X=rp02664-
dc.identifier.authorityLin, X=rp02623-
dc.identifier.authorityKok, KH=rp01455-
dc.identifier.authorityMak, TW=rp02746-
dc.identifier.authorityLu, L=rp00477-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-22242-9-
dc.identifier.pmid33772013-
dc.identifier.pmcidPMC7997921-
dc.identifier.scopuseid_2-s2.0-85103096936-
dc.identifier.hkuros322251-
dc.identifier.volume12-
dc.identifier.spagearticle no. 1914-
dc.identifier.epagearticle no. 1914-
dc.identifier.isiWOS:000635230100018-
dc.publisher.placeUnited Kingdom-

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