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Article: Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor

TitlePotentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor
Authors
Tsz, CMLok, LPNChui, ETFChung, HYC
KeywordsGranulocyte Colony-Stimulating Factor
Systemic Lupus Erythematosus
Leucopenia
Cytokine Storm Syndrome
Azathioprine
Issue Date2021
PublisherWorldScientificOpen Journals. The Journal's web site is located at https://www.worldscientific.com/worldscinet/jcri
Citation
Journal of Clinical Rheumatology and Immunology, 2021, v. 21 n. 1, p. 37-41 How to Cite?
DOI: http://dx.doi.org/10.1142/S2661341721720019
AbstractRecombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.
Persistent Identifierhttp://hdl.handle.net/10722/299108
ISSN
2661-3417

 

DC FieldValueLanguage
dc.contributor.authorTsz, CM-
dc.contributor.authorLok, LPN-
dc.contributor.authorChui, ETF-
dc.contributor.authorChung, HYC-
dc.date.accessioned2021-04-28T02:26:17Z-
dc.date.available2021-04-28T02:26:17Z-
dc.date.issued2021-
dc.identifier.citationJournal of Clinical Rheumatology and Immunology, 2021, v. 21 n. 1, p. 37-41-
dc.identifier.issn2661-3417-
dc.identifier.urihttp://hdl.handle.net/10722/299108-
dc.description.abstractRecombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.-
dc.languageeng-
dc.publisherWorldScientificOpen Journals. The Journal's web site is located at https://www.worldscientific.com/worldscinet/jcri-
dc.relation.ispartofJournal of Clinical Rheumatology and Immunology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectGranulocyte Colony-Stimulating Factor-
dc.subjectSystemic Lupus Erythematosus-
dc.subjectLeucopenia-
dc.subjectCytokine Storm Syndrome-
dc.subjectAzathioprine-
dc.titlePotentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor-
dc.typeArticle-
dc.identifier.emailChung, HYC: jameschy@hku.hk-
dc.identifier.authorityChung, HYC=rp02330-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1142/S2661341721720019-
dc.identifier.hkuros322209-
dc.identifier.volume21-
dc.identifier.issue1-
dc.identifier.spage37-
dc.identifier.epage41-
dc.publisher.placeSingapore-

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