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Article: Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor
Title | Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor |
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Authors | |
Keywords | Granulocyte Colony-Stimulating Factor Systemic Lupus Erythematosus Leucopenia Cytokine Storm Syndrome Azathioprine |
Issue Date | 2021 |
Publisher | WorldScientificOpen Journals. The Journal's web site is located at https://www.worldscientific.com/worldscinet/jcri |
Citation | Journal of Clinical Rheumatology and Immunology, 2021, v. 21 n. 1, p. 37-41 How to Cite? |
Abstract | Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious. |
Persistent Identifier | http://hdl.handle.net/10722/299108 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Tsz, CM | - |
dc.contributor.author | Lok, LPN | - |
dc.contributor.author | Chui, ETF | - |
dc.contributor.author | Chung, HYC | - |
dc.date.accessioned | 2021-04-28T02:26:17Z | - |
dc.date.available | 2021-04-28T02:26:17Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Clinical Rheumatology and Immunology, 2021, v. 21 n. 1, p. 37-41 | - |
dc.identifier.issn | 2661-3417 | - |
dc.identifier.uri | http://hdl.handle.net/10722/299108 | - |
dc.description.abstract | Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious. | - |
dc.language | eng | - |
dc.publisher | WorldScientificOpen Journals. The Journal's web site is located at https://www.worldscientific.com/worldscinet/jcri | - |
dc.relation.ispartof | Journal of Clinical Rheumatology and Immunology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Granulocyte Colony-Stimulating Factor | - |
dc.subject | Systemic Lupus Erythematosus | - |
dc.subject | Leucopenia | - |
dc.subject | Cytokine Storm Syndrome | - |
dc.subject | Azathioprine | - |
dc.title | Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor | - |
dc.type | Article | - |
dc.identifier.email | Chung, HYC: jameschy@hku.hk | - |
dc.identifier.authority | Chung, HYC=rp02330 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1142/S2661341721720019 | - |
dc.identifier.hkuros | 322209 | - |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 37 | - |
dc.identifier.epage | 41 | - |
dc.publisher.place | Singapore | - |