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Article: A heteromodal word-meaning binding site in the visual word form area under top-down frontoparietal control

TitleA heteromodal word-meaning binding site in the visual word form area under top-down frontoparietal control
Authors
Keywordscontrolled semantic cognition
word-meaning binding
visual word form area
word comprehension and production
fMRI
Issue Date2021
PublisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.org
Citation
The Journal of Neuroscience, 2021, v. 41 n. 17, p. 3854-3869 How to Cite?
AbstractThe integral capacity of human language together with semantic memory drives the linkage of words and their meaning, which theoretically is subject to cognitive control. However, it remains unknown whether, across different language modalities and input/output formats, there is a shared system in the human brain for word-meaning binding and how this system interacts with cognitive control. Here, we conducted a functional magnetic resonance imaging experiment based on a large cohort of subjects (50 females, 50 males) to comprehensively measure the brain responses evoked by semantic processing in spoken and written word comprehension and production tasks (listening, speaking, reading and writing). We found that heteromodal word input and output tasks involved distributed brain regions within a frontal-parietal-temporal network and focally coactivated the anterior lateral visual word form area (VWFA), which is located in the basal occipitotemporal area. Directed connectivity analysis revealed that the VWFA was invariably under significant top-down modulation of the frontoparietal control network and interacts with regions related to attention and semantic representation. This study reveals that the VWFA is a key site subserving general semantic processes linking words and meaning, challenging the predominant emphasis on this area’s specific role in reading or other general visual processes. Our findings also suggest that the dynamics between semantic memory and cognitive control mechanisms during word processing are largely independent of the modalities of input or output.
Persistent Identifierhttp://hdl.handle.net/10722/299098
ISSN
2020 Impact Factor: 6.167
2015 SCImago Journal Rankings: 5.105
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorQIN, L-
dc.contributor.authorLyu, B-
dc.contributor.authorShu, S-
dc.contributor.authorYin, Y-
dc.contributor.authorWang, X-
dc.contributor.authorGe, J-
dc.contributor.authorSiok, WT-
dc.contributor.authorGao, JH-
dc.date.accessioned2021-04-28T02:26:09Z-
dc.date.available2021-04-28T02:26:09Z-
dc.date.issued2021-
dc.identifier.citationThe Journal of Neuroscience, 2021, v. 41 n. 17, p. 3854-3869-
dc.identifier.issn0270-6474-
dc.identifier.urihttp://hdl.handle.net/10722/299098-
dc.description.abstractThe integral capacity of human language together with semantic memory drives the linkage of words and their meaning, which theoretically is subject to cognitive control. However, it remains unknown whether, across different language modalities and input/output formats, there is a shared system in the human brain for word-meaning binding and how this system interacts with cognitive control. Here, we conducted a functional magnetic resonance imaging experiment based on a large cohort of subjects (50 females, 50 males) to comprehensively measure the brain responses evoked by semantic processing in spoken and written word comprehension and production tasks (listening, speaking, reading and writing). We found that heteromodal word input and output tasks involved distributed brain regions within a frontal-parietal-temporal network and focally coactivated the anterior lateral visual word form area (VWFA), which is located in the basal occipitotemporal area. Directed connectivity analysis revealed that the VWFA was invariably under significant top-down modulation of the frontoparietal control network and interacts with regions related to attention and semantic representation. This study reveals that the VWFA is a key site subserving general semantic processes linking words and meaning, challenging the predominant emphasis on this area’s specific role in reading or other general visual processes. Our findings also suggest that the dynamics between semantic memory and cognitive control mechanisms during word processing are largely independent of the modalities of input or output.-
dc.languageeng-
dc.publisherSociety for Neuroscience. The Journal's web site is located at http://www.jneurosci.org-
dc.relation.ispartofThe Journal of Neuroscience-
dc.rightsThe Journal of Neuroscience. Copyright © Society for Neuroscience.-
dc.subjectcontrolled semantic cognition-
dc.subjectword-meaning binding-
dc.subjectvisual word form area-
dc.subjectword comprehension and production-
dc.subjectfMRI-
dc.titleA heteromodal word-meaning binding site in the visual word form area under top-down frontoparietal control-
dc.typeArticle-
dc.identifier.emailSiok, WT: siok@hku.hk-
dc.identifier.authoritySiok, WT=rp01208-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1523/JNEUROSCI.2771-20.2021-
dc.identifier.pmid33687963-
dc.identifier.pmcidPMC8084310-
dc.identifier.scopuseid_2-s2.0-85105833266-
dc.identifier.hkuros322205-
dc.identifier.volume41-
dc.identifier.issue17-
dc.identifier.spage3854-
dc.identifier.epage3869-
dc.publisher.placeUnited States-

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