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Article: Bio‐adhesive Nanoporous Module: Toward Autonomous Gating

TitleBio‐adhesive Nanoporous Module: Toward Autonomous Gating
Authors
Keywordsadhesive materials
gating phenomena
host–guest chemistry
porous materials
Issue Date2021
PublisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773
Citation
Angewandte Chemie (International Edition), 2021, v. 60 n. 16, p. 8932-8937 How to Cite?
AbstractHere we report a bio-adhesive porous organic module (GlueCOF) composed of hexagonally packed 1D nanopores based on a covalent organic framework. The nanopores are densely decorated with guanidinium ion (Gu+) pendants capable of forming salt bridges with oxyanionic species. GlueCOF strongly adheres to biopolymers through multivalent salt-bridging interactions with their ubiquitous oxyanionic species. By taking advantage of its strong bio-adhesive nature, we succeeded in creating a gate that possibly opens the nanopores through a selective interaction with a reporter chemical and releases guest molecules. We chose calmodulin (CaM) as a gating component that can stably entrap a loaded guest, sulforhodamine B (SRB), within the nanopores (CaMCOF⊃SRB). CaM is known to change its conformation on binding with Ca2+ ions. We confirmed that mixing CaMCOF⊃SRB with Ca2+ resulted in the release of SRB from the nanopores, whereas the use of weakly binding Mg2+ ions resulted in a much slower release of SRB.
Persistent Identifierhttp://hdl.handle.net/10722/298760
ISSN
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJo, H-
dc.contributor.authorKitao, T-
dc.contributor.authorKimura, A-
dc.contributor.authorItoh, Y-
dc.contributor.authorAida, T-
dc.contributor.authorOkuro, K-
dc.date.accessioned2021-04-12T03:03:00Z-
dc.date.available2021-04-12T03:03:00Z-
dc.date.issued2021-
dc.identifier.citationAngewandte Chemie (International Edition), 2021, v. 60 n. 16, p. 8932-8937-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/298760-
dc.description.abstractHere we report a bio-adhesive porous organic module (GlueCOF) composed of hexagonally packed 1D nanopores based on a covalent organic framework. The nanopores are densely decorated with guanidinium ion (Gu+) pendants capable of forming salt bridges with oxyanionic species. GlueCOF strongly adheres to biopolymers through multivalent salt-bridging interactions with their ubiquitous oxyanionic species. By taking advantage of its strong bio-adhesive nature, we succeeded in creating a gate that possibly opens the nanopores through a selective interaction with a reporter chemical and releases guest molecules. We chose calmodulin (CaM) as a gating component that can stably entrap a loaded guest, sulforhodamine B (SRB), within the nanopores (CaMCOF⊃SRB). CaM is known to change its conformation on binding with Ca2+ ions. We confirmed that mixing CaMCOF⊃SRB with Ca2+ resulted in the release of SRB from the nanopores, whereas the use of weakly binding Mg2+ ions resulted in a much slower release of SRB.-
dc.languageeng-
dc.publisherWiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/15213773-
dc.relation.ispartofAngewandte Chemie (International Edition)-
dc.rightsThis is the peer reviewed version of the following article: Angewandte Chemie (International Edition), 2021, v. 60 n. 16, p. 8932-8937, which has been published in final form at https://doi.org/10.1002/anie.202017117. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectadhesive materials-
dc.subjectgating phenomena-
dc.subjecthost–guest chemistry-
dc.subjectporous materials-
dc.titleBio‐adhesive Nanoporous Module: Toward Autonomous Gating-
dc.typeArticle-
dc.identifier.emailOkuro, K: okuro@hku.hk-
dc.identifier.authorityOkuro, K=rp02557-
dc.description.naturepostprint-
dc.identifier.doi10.1002/anie.202017117-
dc.identifier.pmid33528083-
dc.identifier.scopuseid_2-s2.0-85102037923-
dc.identifier.hkuros322110-
dc.identifier.volume60-
dc.identifier.issue16-
dc.identifier.spage8932-
dc.identifier.epage8937-
dc.identifier.isiWOS:000624600900001-
dc.publisher.placeGermany-

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