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Article: Adiponectin gene therapy for Alzheimer disease in a mouse model: abridged secondary publication

TitleAdiponectin gene therapy for Alzheimer disease in a mouse model: abridged secondary publication
Authors
Ng, RCLJian, MYick, LWBunting, MKwan, JSCChung, SKChan, KH
Issue Date2020
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2020, v. 26 n. 6, suppl. 8, p. 27-33 How to Cite?
Abstract1. Liver-specific expression of trimeric adiponectin can cross the blood-brain barrier. 2. Overexpression of trimeric adiponectin can improve memory function. 3. Overexpression of trimer adiponectin enhances neuronal insulin sensitivity and reduces amyloid-β deposition. 4. Adiponectin suppresses Aβ-induced microglia activation and neuroinflammatory responses, exerting protective effects to neurons and synapses in an Alzheimer disease mouse model. 5. Adiponectin deficiency exacerbates microglia-mediated neuroinflammation in an Alzheimer disease mouse model.
Persistent Identifierhttp://hdl.handle.net/10722/298743
ISSN
1024-2708
2021 Impact Factor: 1.256
2020 SCImago Journal Rankings: 0.357

 

DC FieldValueLanguage
dc.contributor.authorNg, RCL-
dc.contributor.authorJian, M-
dc.contributor.authorYick, LW-
dc.contributor.authorBunting, M-
dc.contributor.authorKwan, JSC-
dc.contributor.authorChung, SK-
dc.contributor.authorChan, KH-
dc.date.accessioned2021-04-12T03:02:46Z-
dc.date.available2021-04-12T03:02:46Z-
dc.date.issued2020-
dc.identifier.citationHong Kong Medical Journal, 2020, v. 26 n. 6, suppl. 8, p. 27-33-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/298743-
dc.description.abstract1. Liver-specific expression of trimeric adiponectin can cross the blood-brain barrier. 2. Overexpression of trimeric adiponectin can improve memory function. 3. Overexpression of trimer adiponectin enhances neuronal insulin sensitivity and reduces amyloid-β deposition. 4. Adiponectin suppresses Aβ-induced microglia activation and neuroinflammatory responses, exerting protective effects to neurons and synapses in an Alzheimer disease mouse model. 5. Adiponectin deficiency exacerbates microglia-mediated neuroinflammation in an Alzheimer disease mouse model.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.titleAdiponectin gene therapy for Alzheimer disease in a mouse model: abridged secondary publication-
dc.typeArticle-
dc.identifier.emailNg, RCL: royclng@hku.hk-
dc.identifier.emailYick, LW: lwyick@hku.hk-
dc.identifier.emailChan, KH: koonho@hku.hk-
dc.identifier.authorityNg, RCL=rp02376-
dc.identifier.authorityChung, SK=rp00381-
dc.identifier.authorityChan, KH=rp00537-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid33504675-
dc.identifier.scopuseid_2-s2.0-85100560493-
dc.identifier.hkuros321931-
dc.identifier.volume26-
dc.identifier.issue6, suppl. 8-
dc.identifier.spage27-
dc.identifier.epage33-
dc.publisher.placeHong Kong-

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