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Article: Inhibition of dentine caries using fluoride solution with silver nanoparticles: An in vitro study

TitleInhibition of dentine caries using fluoride solution with silver nanoparticles: An in vitro study
Authors
KeywordsSilver nanoparticles
Fluoride
Caries
Dentine
Remineralisation
Issue Date2020
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent
Citation
Journal of Dentistry, 2020, v. 103, article no. 103512 How to Cite?
AbstractObjectives: To investigate the remineralising and staining effects of sodium fluoride (NaF) with silver nano-particles (AgNPs) on artificial dentine caries. Methods: Human dentine blocks with artificial caries were divided into four groups. Group 1 received 5 % NaF (22,600 ppm fluoride) with 4000 ppm AgNPs; group 2 received 4000 ppm AgNPs; group 3 received 5 % NaF, group 4 received deionised water (negative control). All groups underwent three biochemical cycles. Each cycle included Streptococcus mutans biofilm challenge and remineralisation process. The lesion depth, mineral-organic content, surface morphology and crystal characteristics of dentine blocks were evaluated using micro-computed tomography, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM) and X-ray diffraction. Colour change of dentine blocks was assessed using spectrophotometry. Results: The mean lesion depths of groups 1–4 were 151.13 ± 29.13 μm, 172.38 ± 23.44 μm, 190.41 ± 32.81 μm and 221.24 ± 27.91 μm, respectively. The hydrogen phosphate-to-amide I ratios of groups 1–4 were 5.98 ± 0.36, 3.86 ± 0.56, 4.00 ± 0.67 and 2.53 ± 0.40, respectively. There was no significant interaction effect between AgNPs and NaF. SEM showed less exposure of dentine collagen fibres in group 1 when compared to other groups. X-ray diffraction revealed presence of silver chloride and metallic silver in group 1 and 2. There was no significant difference in colour change among the four groups (p = 0.74). Conclusions: NaF solution with AgNPs can remineralise dentine caries without staining. Clinical Significance: Sodium fluoride solutions that include silver nanoparticles have potential uses in the management of caries.
Persistent Identifierhttp://hdl.handle.net/10722/298693
ISSN
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 1.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYin, IX-
dc.contributor.authorYu, OY-
dc.contributor.authorZhao, IS-
dc.contributor.authorMei, ML-
dc.contributor.authorLi, QL-
dc.contributor.authorTang, J-
dc.contributor.authorLo, ECM-
dc.contributor.authorChu, CH-
dc.date.accessioned2021-04-12T03:02:05Z-
dc.date.available2021-04-12T03:02:05Z-
dc.date.issued2020-
dc.identifier.citationJournal of Dentistry, 2020, v. 103, article no. 103512-
dc.identifier.issn0300-5712-
dc.identifier.urihttp://hdl.handle.net/10722/298693-
dc.description.abstractObjectives: To investigate the remineralising and staining effects of sodium fluoride (NaF) with silver nano-particles (AgNPs) on artificial dentine caries. Methods: Human dentine blocks with artificial caries were divided into four groups. Group 1 received 5 % NaF (22,600 ppm fluoride) with 4000 ppm AgNPs; group 2 received 4000 ppm AgNPs; group 3 received 5 % NaF, group 4 received deionised water (negative control). All groups underwent three biochemical cycles. Each cycle included Streptococcus mutans biofilm challenge and remineralisation process. The lesion depth, mineral-organic content, surface morphology and crystal characteristics of dentine blocks were evaluated using micro-computed tomography, Fourier transform infrared spectroscopy, scanning electron microscopy (SEM) and X-ray diffraction. Colour change of dentine blocks was assessed using spectrophotometry. Results: The mean lesion depths of groups 1–4 were 151.13 ± 29.13 μm, 172.38 ± 23.44 μm, 190.41 ± 32.81 μm and 221.24 ± 27.91 μm, respectively. The hydrogen phosphate-to-amide I ratios of groups 1–4 were 5.98 ± 0.36, 3.86 ± 0.56, 4.00 ± 0.67 and 2.53 ± 0.40, respectively. There was no significant interaction effect between AgNPs and NaF. SEM showed less exposure of dentine collagen fibres in group 1 when compared to other groups. X-ray diffraction revealed presence of silver chloride and metallic silver in group 1 and 2. There was no significant difference in colour change among the four groups (p = 0.74). Conclusions: NaF solution with AgNPs can remineralise dentine caries without staining. Clinical Significance: Sodium fluoride solutions that include silver nanoparticles have potential uses in the management of caries.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent-
dc.relation.ispartofJournal of Dentistry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectSilver nanoparticles-
dc.subjectFluoride-
dc.subjectCaries-
dc.subjectDentine-
dc.subjectRemineralisation-
dc.titleInhibition of dentine caries using fluoride solution with silver nanoparticles: An in vitro study-
dc.typeArticle-
dc.identifier.emailYin, IX: irisxyin@hku.hk-
dc.identifier.emailYu, OY: ollieyu@hku.hk-
dc.identifier.emailLo, ECM: edward-lo@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityYu, OY=rp02658-
dc.identifier.authorityLo, ECM=rp00015-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.jdent.2020.103512-
dc.identifier.pmid33157159-
dc.identifier.scopuseid_2-s2.0-85096476930-
dc.identifier.hkuros322045-
dc.identifier.volume103-
dc.identifier.spagearticle no. 103512-
dc.identifier.epagearticle no. 103512-
dc.identifier.isiWOS:000600291800002-
dc.publisher.placeUnited Kingdom-

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