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Article: Comparison of corneal biomechanics among primary open-angle glaucoma with normal tension or hypertension and controls

TitleComparison of corneal biomechanics among primary open-angle glaucoma with normal tension or hypertension and controls
Authors
KeywordsCorneal biomechanics
Primary open-angle glaucoma
Normal tension glaucoma
Hypertensive glaucoma
Issue Date2021
PublisherWolters Kluwer - Medknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2021, v. 134 n. 9, p. 1087-1092 How to Cite?
AbstractBackground: Normal tension glaucoma (NTG) is a less pressure-dependent type of glaucoma with characteristic optic neuropathy. Recently, the biomechanical mechanism has been thought to account for glaucomatous optic neuropathy to some degree. We intended to compare dynamic corneal response parameters (DCRs) among patients with primary open-angle glaucoma with normal tension or hypertension and controls. The correlations between DCRs and known risk factors for glaucoma were also analyzed. Methods: In this cross-sectional study, 49 NTG subjects, 45 hypertension glaucoma (HTG) subjects, and 50 control subjects were enrolled. We compared the differences in DCRs using corneal visualization Scheimpflug technology among the NTG, HTG, and control groups. We also analyzed the correlations between DCRs and known risk factors for glaucoma (eg, central corneal thickness [CCT], intraocular pressure [IOP], etc). Results: The maximum inverse concave radius (NTG: 0.18 [0.17, 0.20] mm−1; control: 0.17 [0.16, 0.18] mm−1; P = 0.033), deformation amplitude ratio of 2 mm (DAR 2 mm, NTG: 4.87 [4.33, 5.39]; control: 4.37 [4.07, 4.88]; P < 0.001), and DAR 1 mm (NTG: 1.62 [1.58, 1.65]; control: 1.58 [1.54, 1.61]; P < 0.001) were significantly higher in NTG than in the controls. The integrated radius (IR, NTG: 8.40 ± 1.07 mm−1; HTG: 7.64 ± 1.31 mm−1; P = 0.026) and DAR 2 mm (NTG: 4.87 [4.33, 5.39]; HTG: 4.44 [4.12, 5.02]; P < 0.007) were significantly higher, whereas the stiffness parameter at the first applanation (SP-A1, NTG: 91.23 [77.45, 107.45]; HTG: 102.36 [85.77, 125.12]; P = 0.007) was lower in NTG than in HTG. There were no significant differences in the DCRs between HTG and control groups (P > 0.05). In the univariate and multivariate analyses, some of the DCRs, such as IR, were negatively correlated with CCT and IOP, whereas SP-A1 was positively correlated with CCT and IOP. Conclusions: The cornea was more deformable in NTG than in HTG or controls. There were no significant differences in corneal deformability between HTG and controls. The cornea was more deformable with the thinner cornea and lower IOP.
Persistent Identifierhttp://hdl.handle.net/10722/298681
ISSN
2023 Impact Factor: 7.5
2023 SCImago Journal Rankings: 0.997
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWei, YH-
dc.contributor.authorCai, Y-
dc.contributor.authorChoy, BNK-
dc.contributor.authorLi, BB-
dc.contributor.authorLi, RS-
dc.contributor.authorXing, C-
dc.contributor.authorWang, X-
dc.contributor.authorTian, T-
dc.contributor.authorFang, Y-
dc.contributor.authorLi, M-
dc.contributor.authorPan, YZ-
dc.date.accessioned2021-04-12T03:01:55Z-
dc.date.available2021-04-12T03:01:55Z-
dc.date.issued2021-
dc.identifier.citationChinese Medical Journal, 2021, v. 134 n. 9, p. 1087-1092-
dc.identifier.issn0366-6999-
dc.identifier.urihttp://hdl.handle.net/10722/298681-
dc.description.abstractBackground: Normal tension glaucoma (NTG) is a less pressure-dependent type of glaucoma with characteristic optic neuropathy. Recently, the biomechanical mechanism has been thought to account for glaucomatous optic neuropathy to some degree. We intended to compare dynamic corneal response parameters (DCRs) among patients with primary open-angle glaucoma with normal tension or hypertension and controls. The correlations between DCRs and known risk factors for glaucoma were also analyzed. Methods: In this cross-sectional study, 49 NTG subjects, 45 hypertension glaucoma (HTG) subjects, and 50 control subjects were enrolled. We compared the differences in DCRs using corneal visualization Scheimpflug technology among the NTG, HTG, and control groups. We also analyzed the correlations between DCRs and known risk factors for glaucoma (eg, central corneal thickness [CCT], intraocular pressure [IOP], etc). Results: The maximum inverse concave radius (NTG: 0.18 [0.17, 0.20] mm−1; control: 0.17 [0.16, 0.18] mm−1; P = 0.033), deformation amplitude ratio of 2 mm (DAR 2 mm, NTG: 4.87 [4.33, 5.39]; control: 4.37 [4.07, 4.88]; P < 0.001), and DAR 1 mm (NTG: 1.62 [1.58, 1.65]; control: 1.58 [1.54, 1.61]; P < 0.001) were significantly higher in NTG than in the controls. The integrated radius (IR, NTG: 8.40 ± 1.07 mm−1; HTG: 7.64 ± 1.31 mm−1; P = 0.026) and DAR 2 mm (NTG: 4.87 [4.33, 5.39]; HTG: 4.44 [4.12, 5.02]; P < 0.007) were significantly higher, whereas the stiffness parameter at the first applanation (SP-A1, NTG: 91.23 [77.45, 107.45]; HTG: 102.36 [85.77, 125.12]; P = 0.007) was lower in NTG than in HTG. There were no significant differences in the DCRs between HTG and control groups (P > 0.05). In the univariate and multivariate analyses, some of the DCRs, such as IR, were negatively correlated with CCT and IOP, whereas SP-A1 was positively correlated with CCT and IOP. Conclusions: The cornea was more deformable in NTG than in HTG or controls. There were no significant differences in corneal deformability between HTG and controls. The cornea was more deformable with the thinner cornea and lower IOP.-
dc.languageeng-
dc.publisherWolters Kluwer - Medknow Publications and Media Pvt. Ltd. The Journal's web site is located at http://www.cmj.org/-
dc.relation.ispartofChinese Medical Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCorneal biomechanics-
dc.subjectPrimary open-angle glaucoma-
dc.subjectNormal tension glaucoma-
dc.subjectHypertensive glaucoma-
dc.titleComparison of corneal biomechanics among primary open-angle glaucoma with normal tension or hypertension and controls-
dc.typeArticle-
dc.identifier.emailChoy, BNK: bnkchoy@hku.hk-
dc.identifier.authorityChoy, BNK=rp01795-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1097/CM9.0000000000001399-
dc.identifier.pmid33813516-
dc.identifier.pmcidPMC8116033-
dc.identifier.scopuseid_2-s2.0-85106068960-
dc.identifier.hkuros322166-
dc.identifier.volume134-
dc.identifier.issue9-
dc.identifier.spage1087-
dc.identifier.epage1092-
dc.identifier.isiWOS:000657769300013-
dc.publisher.placeIndia-

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