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Conference Paper: Regulation of muscle physiology by 7,8-dihydroxyflavone
Title | Regulation of muscle physiology by 7,8-dihydroxyflavone |
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Authors | |
Issue Date | 2018 |
Publisher | Okayama Prefectural University, Okayama Bioactive Research Society. |
Citation | 3rd International Conference on Biologically Active Substances (Bioactive Okayama 2018), Joint Conference of Okayama Bioactive Research Society Symposium and 12th Joint Conference on Nutrition and Food Science, Okayama, 16 October 2018 How to Cite? |
Abstract | Obesity is a result of imbalanced energy intake and expenditure. Since skeletal muscle is the largest
contributor to overall metabolic rate, enhancing energy expenditure in this tissue is a potential method
to reduce the body weight gain during energy surplus. In our attempts to identify new bioavailable
compounds with anti-obesity activities, we found that 7,8-dihydroxyflavone (7,8-DHF), a naturally
occurring flavone in Godmania aesculifolia, increased mitochondrial biogenesis and lipid oxidation
in cultured muscle cells via the brain-derived neurotrophic factor (BDNF) receptor/ AMP-activated
protein kinase (AMPK)/ peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)
pathway. In obese mice, 7,8-DHF consumption increased the muscular mitochondrial content and
uncoupling protein 1 (UCP1) expression. Systemic energy metabolism was thus elevated, which
reduced their body weight gain. Consequently, hyperlipidemia, hyperglycemia hyperinsulinemia,
ectopic lipid accumulation, and insulin resistance in the skeletal muscle of these obese animals were
alleviated after 7,8-DHF treatment. 7,8-DHF also possesses a preventive activity against obesity
development as high-fat diet (HFD) feeding induced less body weight gain in C57BL/6 mice
receiving 7,8-DHF simultaneously. Together, our results demonstrate that 7,8-DHF is an effective
anti-obesity agent in both normal and obese animals. |
Description | Session II: Food and Nutrition Research in East Asia and the Surrounds (2) - no. O-5 Co-organized by Okayama Bioactive Research Society and Okayama Prefectural University |
Persistent Identifier | http://hdl.handle.net/10722/298618 |
DC Field | Value | Language |
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dc.contributor.author | Chan, CB | - |
dc.date.accessioned | 2021-04-08T06:21:38Z | - |
dc.date.available | 2021-04-08T06:21:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | 3rd International Conference on Biologically Active Substances (Bioactive Okayama 2018), Joint Conference of Okayama Bioactive Research Society Symposium and 12th Joint Conference on Nutrition and Food Science, Okayama, 16 October 2018 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298618 | - |
dc.description | Session II: Food and Nutrition Research in East Asia and the Surrounds (2) - no. O-5 | - |
dc.description | Co-organized by Okayama Bioactive Research Society and Okayama Prefectural University | - |
dc.description.abstract | Obesity is a result of imbalanced energy intake and expenditure. Since skeletal muscle is the largest contributor to overall metabolic rate, enhancing energy expenditure in this tissue is a potential method to reduce the body weight gain during energy surplus. In our attempts to identify new bioavailable compounds with anti-obesity activities, we found that 7,8-dihydroxyflavone (7,8-DHF), a naturally occurring flavone in Godmania aesculifolia, increased mitochondrial biogenesis and lipid oxidation in cultured muscle cells via the brain-derived neurotrophic factor (BDNF) receptor/ AMP-activated protein kinase (AMPK)/ peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) pathway. In obese mice, 7,8-DHF consumption increased the muscular mitochondrial content and uncoupling protein 1 (UCP1) expression. Systemic energy metabolism was thus elevated, which reduced their body weight gain. Consequently, hyperlipidemia, hyperglycemia hyperinsulinemia, ectopic lipid accumulation, and insulin resistance in the skeletal muscle of these obese animals were alleviated after 7,8-DHF treatment. 7,8-DHF also possesses a preventive activity against obesity development as high-fat diet (HFD) feeding induced less body weight gain in C57BL/6 mice receiving 7,8-DHF simultaneously. Together, our results demonstrate that 7,8-DHF is an effective anti-obesity agent in both normal and obese animals. | - |
dc.language | eng | - |
dc.publisher | Okayama Prefectural University, Okayama Bioactive Research Society. | - |
dc.relation.ispartof | 3rd International Conference on Biologically Active Substances (Bioactive Okayama 2018) | - |
dc.title | Regulation of muscle physiology by 7,8-dihydroxyflavone | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, CB: chancb@hku.hk | - |
dc.identifier.authority | Chan, CB=rp02140 | - |
dc.identifier.hkuros | 301934 | - |
dc.publisher.place | Japan | - |