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Article: Integrating carbon nanotubes and lipid bilayer for biosensing

TitleIntegrating carbon nanotubes and lipid bilayer for biosensing
Authors
KeywordsMembrane proteins
Lipid bilayer
Bioelectronics
Carbon nanotubes
Issue Date2010
Citation
Biosensors and Bioelectronics, 2010, v. 25, n. 7, p. 1834-1837 How to Cite?
AbstractMembrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening. © 2009 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/298495
ISSN
2020 Impact Factor: 10.618
2020 SCImago Journal Rankings: 2.546
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, Yinxi-
dc.contributor.authorPalkar, Preeti Vikas-
dc.contributor.authorLi, Lain Jong-
dc.contributor.authorZhang, Hua-
dc.contributor.authorChen, Peng-
dc.date.accessioned2021-04-08T03:08:37Z-
dc.date.available2021-04-08T03:08:37Z-
dc.date.issued2010-
dc.identifier.citationBiosensors and Bioelectronics, 2010, v. 25, n. 7, p. 1834-1837-
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/10722/298495-
dc.description.abstractMembrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening. © 2009 Elsevier B.V.-
dc.languageeng-
dc.relation.ispartofBiosensors and Bioelectronics-
dc.subjectMembrane proteins-
dc.subjectLipid bilayer-
dc.subjectBioelectronics-
dc.subjectCarbon nanotubes-
dc.titleIntegrating carbon nanotubes and lipid bilayer for biosensing-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bios.2009.12.011-
dc.identifier.pmid20047826-
dc.identifier.scopuseid_2-s2.0-77952317291-
dc.identifier.volume25-
dc.identifier.issue7-
dc.identifier.spage1834-
dc.identifier.epage1837-
dc.identifier.eissn1873-4235-
dc.identifier.isiWOS:000275978700046-
dc.identifier.issnl0956-5663-

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