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Article: Label-free detection of ATP release from living astrocytes with high temporal resolution using carbon nanotube network

TitleLabel-free detection of ATP release from living astrocytes with high temporal resolution using carbon nanotube network
Authors
KeywordsSecretion
Carbon nanotubes
ATP
Astrocytes
Issue Date2009
Citation
Biosensors and Bioelectronics, 2009, v. 24, n. 8, p. 2716-2720 How to Cite?
AbstractOwing to its unique combination of electrical, physiochemical, and one-dimension structural properties, single-walled carbon nanotube (SWNT) has recently emerged as a novel nanoelectronic biosensor for biomolecular detection with extraordinary sensitivity and simple detection scheme. All the realizations so far, however, are limited to static in vitro measurement. Dynamic detection of biomolecule release from living cells which may occur in millisecond timescale has yet to be demonstrated. In the present work, SWNT network was utilized to directly interface with living neuroglial astrocytes and label-freely detect the triggered release of adenosine triphosphate (ATP) from these cells with high temporal resolution. The secreted ATP molecules diffuse into the narrow interface gap between the SWNT-net and the astrocyte, and interact with the nanotubes. Highly charged ATP molecules electrostatically modulate the SWNT conductance leading to measurable current response. This technique provides a novel platform to study ATP release and signaling which play important roles in astrocyte-neuron crosstalk and other essential cellular functions. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/298473
ISSN
2020 Impact Factor: 10.618
2020 SCImago Journal Rankings: 2.546
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, Yinxi-
dc.contributor.authorSudibya, Herry Gunadi-
dc.contributor.authorFu, Dongliang-
dc.contributor.authorXue, Renhao-
dc.contributor.authorDong, Xiaochen-
dc.contributor.authorLi, Lain Jong-
dc.contributor.authorChen, Peng-
dc.date.accessioned2021-04-08T03:08:30Z-
dc.date.available2021-04-08T03:08:30Z-
dc.date.issued2009-
dc.identifier.citationBiosensors and Bioelectronics, 2009, v. 24, n. 8, p. 2716-2720-
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/10722/298473-
dc.description.abstractOwing to its unique combination of electrical, physiochemical, and one-dimension structural properties, single-walled carbon nanotube (SWNT) has recently emerged as a novel nanoelectronic biosensor for biomolecular detection with extraordinary sensitivity and simple detection scheme. All the realizations so far, however, are limited to static in vitro measurement. Dynamic detection of biomolecule release from living cells which may occur in millisecond timescale has yet to be demonstrated. In the present work, SWNT network was utilized to directly interface with living neuroglial astrocytes and label-freely detect the triggered release of adenosine triphosphate (ATP) from these cells with high temporal resolution. The secreted ATP molecules diffuse into the narrow interface gap between the SWNT-net and the astrocyte, and interact with the nanotubes. Highly charged ATP molecules electrostatically modulate the SWNT conductance leading to measurable current response. This technique provides a novel platform to study ATP release and signaling which play important roles in astrocyte-neuron crosstalk and other essential cellular functions. © 2008 Elsevier B.V. All rights reserved.-
dc.languageeng-
dc.relation.ispartofBiosensors and Bioelectronics-
dc.subjectSecretion-
dc.subjectCarbon nanotubes-
dc.subjectATP-
dc.subjectAstrocytes-
dc.titleLabel-free detection of ATP release from living astrocytes with high temporal resolution using carbon nanotube network-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bios.2008.12.006-
dc.identifier.pmid19135355-
dc.identifier.scopuseid_2-s2.0-62649146835-
dc.identifier.volume24-
dc.identifier.issue8-
dc.identifier.spage2716-
dc.identifier.epage2720-
dc.identifier.isiWOS:000265811000067-
dc.identifier.issnl0956-5663-

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