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Article: Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles

TitleNanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles
Authors
Issue Date2009
Citation
Advanced Materials, 2009, v. 21, n. 7, p. 790-793 How to Cite?
AbstractA study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.
Persistent Identifierhttp://hdl.handle.net/10722/298471
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jing-
dc.contributor.authorFu, Dongliang-
dc.contributor.authorChan-Park, Mary B.-
dc.contributor.authorLi, Lain Jong-
dc.contributor.authorChen, Peng-
dc.date.accessioned2021-04-08T03:08:29Z-
dc.date.available2021-04-08T03:08:29Z-
dc.date.issued2009-
dc.identifier.citationAdvanced Materials, 2009, v. 21, n. 7, p. 790-793-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/298471-
dc.description.abstractA study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures.-
dc.languageeng-
dc.relation.ispartofAdvanced Materials-
dc.titleNanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.200801586-
dc.identifier.scopuseid_2-s2.0-60349102968-
dc.identifier.volume21-
dc.identifier.issue7-
dc.identifier.spage790-
dc.identifier.epage793-
dc.identifier.isiWOS:000263737800008-
dc.identifier.issnl0935-9648-

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