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- Publisher Website: 10.1016/j.tcb.2016.09.010
- Scopus: eid_2-s2.0-85005808039
- PMID: 27765513
- WOS: WOS:000393927300003
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Article: Microtubule Motors Drive Hedgehog Signaling in Primary Cilia
Title | Microtubule Motors Drive Hedgehog Signaling in Primary Cilia |
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Authors | |
Keywords | Hedgehog pathway dynein ciliopathies kinesin microtubules primary cilia |
Issue Date | 2017 |
Citation | Trends in Cell Biology, 2017, v. 27, n. 2, p. 110-125 How to Cite? |
Abstract | The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. All responses to Hh family ligands in mammals require the primary cilium, an ancient microtubule-based organelle that extends from the cell surface. Genetic studies in mice and humans have defined specific functions for cilium-associated microtubule motor proteins: they act in the construction and disassembly of the primary cilium, they control ciliary length and stability, and some have direct roles in mammalian Hh signal transduction. These studies highlight how integrated genetic and cell biological studies can define the molecular mechanisms that underlie cilium-associated health and disease. |
Persistent Identifier | http://hdl.handle.net/10722/298186 |
ISSN | 2023 Impact Factor: 13.0 2023 SCImago Journal Rankings: 6.002 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | He, Mu | - |
dc.contributor.author | Agbu, Stephanie | - |
dc.contributor.author | Anderson, Kathryn V. | - |
dc.date.accessioned | 2021-04-08T03:07:52Z | - |
dc.date.available | 2021-04-08T03:07:52Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Trends in Cell Biology, 2017, v. 27, n. 2, p. 110-125 | - |
dc.identifier.issn | 0962-8924 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298186 | - |
dc.description.abstract | The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. All responses to Hh family ligands in mammals require the primary cilium, an ancient microtubule-based organelle that extends from the cell surface. Genetic studies in mice and humans have defined specific functions for cilium-associated microtubule motor proteins: they act in the construction and disassembly of the primary cilium, they control ciliary length and stability, and some have direct roles in mammalian Hh signal transduction. These studies highlight how integrated genetic and cell biological studies can define the molecular mechanisms that underlie cilium-associated health and disease. | - |
dc.language | eng | - |
dc.relation.ispartof | Trends in Cell Biology | - |
dc.subject | Hedgehog pathway | - |
dc.subject | dynein | - |
dc.subject | ciliopathies | - |
dc.subject | kinesin | - |
dc.subject | microtubules | - |
dc.subject | primary cilia | - |
dc.title | Microtubule Motors Drive Hedgehog Signaling in Primary Cilia | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.tcb.2016.09.010 | - |
dc.identifier.pmid | 27765513 | - |
dc.identifier.pmcid | PMC5258846 | - |
dc.identifier.scopus | eid_2-s2.0-85005808039 | - |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 110 | - |
dc.identifier.epage | 125 | - |
dc.identifier.eissn | 1879-3088 | - |
dc.identifier.isi | WOS:000393927300003 | - |
dc.identifier.issnl | 0962-8924 | - |