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Article: Anterior chamber angle imaging with swept-source optical coherence tomography: Measuring peripheral anterior synechia in glaucoma

TitleAnterior chamber angle imaging with swept-source optical coherence tomography: Measuring peripheral anterior synechia in glaucoma
Authors
Issue Date2013
Citation
Ophthalmology, 2013, v. 120, n. 6, p. 1144-1149 How to Cite?
AbstractObjective: To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. Design: Cross-sectional study. Participants: Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and Axenfeld-Rieger syndrome [n = 1]). Methods: The anterior chamber angles were evaluated with indentation gonioscopy and imaged by swept-source OCT (Casia OCT, Tomey, Nagoya, Japan) in room light and in the dark using the "angle analysis" protocol, which was composed of 128 radial B-scans each with 512 A-scans (16-mm scan length). The area and degree of PAS involvement were measured in each eye after manual detection of the scleral spur and the anterior irido-angle adhesion by 2 masked observers. The interobserver variability of the PAS measurements was calculated. Main Outcome Measures: The agreement of PAS assessment by gonioscopy and OCT, the area and the degree of PAS involvement, and the intraclass correlation coefficient (ICC) of interobserver PAS measurements. Results: The area of PAS (mean ± standard deviation) was 20.8±16.9 mm (range, 3.9-74.9 mm ), and the degree of PAS involvement was 186.5±79.9 degrees (range, 42-314 degrees). There was no difference in the area of PAS (P = 0.90) and the degree of PAS involvement (P = 0.95) between images obtained in room light and in the dark. The interobserver ICCs were 0.99 (95% confidence interval [CI], 0.98-1.00) for the area of PAS and 0.99 (95% CI, 0.97-1.00) for the degree of PAS involvement. There was good agreement of PAS assessment between gonioscopy and OCT images (kappa = 0.79; 95% CI, 0.67-0.91). Conclusions: Swept-source OCT allows visualization and reproducible measurements of the area and degree of PAS involvement, providing a new paradigm for evaluation of PAS progression and risk assessment for development of angle-closure glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2013 American Academy of Ophthalmology. 2 2
Persistent Identifierhttp://hdl.handle.net/10722/298035
ISSN
2023 Impact Factor: 13.1
2023 SCImago Journal Rankings: 4.642
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, Isabel-
dc.contributor.authorMak, Heather-
dc.contributor.authorLai, Gilda-
dc.contributor.authorYu, Marco-
dc.contributor.authorLam, Dennis S.C.-
dc.contributor.authorLeung, Christopher K.S.-
dc.date.accessioned2021-04-08T03:07:31Z-
dc.date.available2021-04-08T03:07:31Z-
dc.date.issued2013-
dc.identifier.citationOphthalmology, 2013, v. 120, n. 6, p. 1144-1149-
dc.identifier.issn0161-6420-
dc.identifier.urihttp://hdl.handle.net/10722/298035-
dc.description.abstractObjective: To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. Design: Cross-sectional study. Participants: Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and Axenfeld-Rieger syndrome [n = 1]). Methods: The anterior chamber angles were evaluated with indentation gonioscopy and imaged by swept-source OCT (Casia OCT, Tomey, Nagoya, Japan) in room light and in the dark using the "angle analysis" protocol, which was composed of 128 radial B-scans each with 512 A-scans (16-mm scan length). The area and degree of PAS involvement were measured in each eye after manual detection of the scleral spur and the anterior irido-angle adhesion by 2 masked observers. The interobserver variability of the PAS measurements was calculated. Main Outcome Measures: The agreement of PAS assessment by gonioscopy and OCT, the area and the degree of PAS involvement, and the intraclass correlation coefficient (ICC) of interobserver PAS measurements. Results: The area of PAS (mean ± standard deviation) was 20.8±16.9 mm (range, 3.9-74.9 mm ), and the degree of PAS involvement was 186.5±79.9 degrees (range, 42-314 degrees). There was no difference in the area of PAS (P = 0.90) and the degree of PAS involvement (P = 0.95) between images obtained in room light and in the dark. The interobserver ICCs were 0.99 (95% confidence interval [CI], 0.98-1.00) for the area of PAS and 0.99 (95% CI, 0.97-1.00) for the degree of PAS involvement. There was good agreement of PAS assessment between gonioscopy and OCT images (kappa = 0.79; 95% CI, 0.67-0.91). Conclusions: Swept-source OCT allows visualization and reproducible measurements of the area and degree of PAS involvement, providing a new paradigm for evaluation of PAS progression and risk assessment for development of angle-closure glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2013 American Academy of Ophthalmology. 2 2-
dc.languageeng-
dc.relation.ispartofOphthalmology-
dc.titleAnterior chamber angle imaging with swept-source optical coherence tomography: Measuring peripheral anterior synechia in glaucoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ophtha.2012.12.006-
dc.identifier.pmid23522970-
dc.identifier.scopuseid_2-s2.0-84878595979-
dc.identifier.volume120-
dc.identifier.issue6-
dc.identifier.spage1144-
dc.identifier.epage1149-
dc.identifier.eissn1549-4713-
dc.identifier.isiWOS:000320650700017-
dc.identifier.issnl0161-6420-

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